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Results: 1 to 20 of 107

1.

Highly pathogenic Alzheimer's disease presenilin 1 P117R mutation causes a specific increase in p53 and p21 protein levels and cell cycle dysregulation in human lymphocytes.

Bialopiotrowicz E, Szybinska A, Kuzniewska B, Buizza L, Uberti D, Kuznicki J, Wojda U.

J Alzheimers Dis. 2012;32(2):397-415. doi: 10.3233/JAD-2012-121129.

PMID:
22810102
[PubMed - indexed for MEDLINE]
2.

Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.

J Alzheimers Dis. 2009;16(3):565-75. doi: 10.3233/JAD-2009-0990.

PMID:
19276551
[PubMed - indexed for MEDLINE]
3.

Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.

Neurosci Res. 2007 Mar;57(3):446-53. Epub 2007 Jan 8.

PMID:
17210196
[PubMed - indexed for MEDLINE]
4.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
[PubMed - indexed for MEDLINE]
5.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.

PMID:
18430735
[PubMed - indexed for MEDLINE]
Free Article
6.

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Heilig EA, Xia W, Shen J, Kelleher RJ 3rd.

J Biol Chem. 2010 Jul 16;285(29):22350-9. doi: 10.1074/jbc.M110.116962. Epub 2010 May 11.

PMID:
20460383
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

Alves da Costa C, Sunyach C, Pardossi-Piquard R, Sévalle J, Vincent B, Boyer N, Kawarai T, Girardot N, St George-Hyslop P, Checler F.

J Neurosci. 2006 Jun 7;26(23):6377-85.

PMID:
16763046
[PubMed - indexed for MEDLINE]
Free Article
8.

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.

J Biol Chem. 2007 Aug 24;282(34):24504-13. Epub 2007 Jun 15.

PMID:
17573346
[PubMed - indexed for MEDLINE]
Free Article
9.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
[PubMed - indexed for MEDLINE]
10.

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C.

J Biol Chem. 2008 Jan 11;283(2):677-83. Epub 2007 Oct 24.

PMID:
17962197
[PubMed - indexed for MEDLINE]
Free Article
11.

Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.

Kaneko H, Kakita A, Kasuga K, Nozaki H, Ishikawa A, Miyashita A, Kuwano R, Ito G, Iwatsubo T, Takahashi H, Nishizawa M, Onodera O, Sisodia SS, Ikeuchi T.

J Neurosci. 2007 Nov 28;27(48):13092-7.

PMID:
18045903
[PubMed - indexed for MEDLINE]
Free Article
12.

A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.

Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C.

J Biol Chem. 2001 Mar 9;276(10):7233-9. Epub 2000 Nov 17.

PMID:
11084029
[PubMed - indexed for MEDLINE]
Free Article
13.

Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.

Malik B, Currais A, Soriano S.

J Neurochem. 2008 Jul;106(2):912-6. doi: 10.1111/j.1471-4159.2008.05446.x. Epub 2008 May 2.

PMID:
18466334
[PubMed - indexed for MEDLINE]
14.

Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)].

Esteras N, Bartolomé F, Alquézar C, Antequera D, Muñoz Ú, Carro E, Martín-Requero Á.

Eur J Neurosci. 2012 Sep;36(5):2609-18. doi: 10.1111/j.1460-9568.2012.08178.x. Epub 2012 Jun 15.

PMID:
22702220
[PubMed - indexed for MEDLINE]
15.

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.

Woodhouse A, Shepherd CE, Sokolova A, Carroll VL, King AE, Halliday GM, Dickson TC, Vickers JC.

Acta Neuropathol. 2009 Jan;117(1):19-29. doi: 10.1007/s00401-008-0458-z. Epub 2008 Nov 18.

PMID:
19015863
[PubMed - indexed for MEDLINE]
16.

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8025-30. Epub 2002 Jun 4.

PMID:
12048239
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cell cycle regulation distinguishes lymphocytes from sporadic and familial Alzheimer's disease patients.

Bialopiotrowicz E, Kuzniewska B, Kachamakova-Trojanowska N, Barcikowska M, Kuznicki J, Wojda U.

Neurobiol Aging. 2011 Dec;32(12):2319.e13-26. doi: 10.1016/j.neurobiolaging.2010.04.017. Epub 2010 Jun 11.

PMID:
20541838
[PubMed - indexed for MEDLINE]
18.

Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells.

Ramalho RM, Borralho PM, Castro RE, Solá S, Steer CJ, Rodrigues CM.

J Neurochem. 2006 Sep;98(5):1610-8.

PMID:
16923170
[PubMed - indexed for MEDLINE]
19.

Implications of presenilin 1 mutations in Alzheimer's disease.

Komano H, Sudoh S, Kawamura Y, Wang R, Yanagisawa K.

Mech Ageing Dev. 1999 Mar 15;107(3):281-98.

PMID:
10360683
[PubMed - indexed for MEDLINE]
20.

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR.

Hum Mol Genet. 2004 Jan 15;13(2):159-70. Epub 2003 Nov 25.

PMID:
14645205
[PubMed - indexed for MEDLINE]
Free Article

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