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Items: 1 to 20 of 74


Getting out of a sticky situation: targeting the myofibroblast in scleroderma.

Leask A.

Open Rheumatol J. 2012;6:163-9. doi: 10.2174/1874312901206010163. Epub 2012 Jun 15.


Towards an anti-fibrotic therapy for scleroderma: targeting myofibroblast differentiation and recruitment.

Leask A.

Fibrogenesis Tissue Repair. 2010 May 27;3:8. doi: 10.1186/1755-1536-3-8.


Possible strategies for anti-fibrotic drug intervention in scleroderma.

Leask A.

J Cell Commun Signal. 2011 Jun;5(2):125-9. doi: 10.1007/s12079-011-0122-6. Epub 2011 Jan 29.


Rac inhibition reverses the phenotype of fibrotic fibroblasts.

Xu SW, Liu S, Eastwood M, Sonnylal S, Denton CP, Abraham DJ, Leask A.

PLoS One. 2009 Oct 13;4(10):e7438. doi: 10.1371/journal.pone.0007438.


Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ.

Mol Biol Cell. 2004 Jun;15(6):2707-19. Epub 2004 Mar 26.


Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.

Serratì S, Chillà A, Laurenzana A, Margheri F, Giannoni E, Magnelli L, Chiarugi P, Dotor J, Feijoo E, Bazzichi L, Bombardieri S, Kahaleh B, Fibbi G, Del Rosso M.

Arthritis Rheum. 2013 Jan;65(1):258-69. doi: 10.1002/art.37705.


Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients.

Manetti M, Neumann E, Milia AF, Tarner IH, Bechi P, Matucci-Cerinic M, Ibba-Manneschi L, Müller-Ladner U.

Arthritis Rheum. 2007 Oct;56(10):3442-7.


Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.

Dooley A, Shi-Wen X, Aden N, Tranah T, Desai N, Denton CP, Abraham DJ, Bruckdorfer R.

Rheumatology (Oxford). 2010 Nov;49(11):2024-36. doi: 10.1093/rheumatology/keq208. Epub 2010 Jul 13.


CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.

Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A.

J Biol Chem. 2001 Apr 6;276(14):10594-601. Epub 2001 Jan 4.


Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation.

Carulli MT, Ong VH, Ponticos M, Shiwen X, Abraham DJ, Black CM, Denton CP.

Arthritis Rheum. 2005 Dec;52(12):3772-82.


Lysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblasts.

Yin Z, Carbone LD, Gotoh M, Postlethwaite A, Bolen AL, Tigyi GJ, Murakami-Murofushi K, Watsky MA.

Rheumatology (Oxford). 2010 Dec;49(12):2290-7. doi: 10.1093/rheumatology/keq260. Epub 2010 Sep 7.


The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: reconstitution of skin fibrosis development using a tissue engineering approach.

Corriveau MP, Boufaied I, Lessard J, Chabaud S, Senécal JL, Grodzicky T, Chartier S, Raymond Y, Moulin VJ.

J Pathol. 2009 Mar;217(4):534-42. doi: 10.1002/path.2482.


Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate.

Pannu J, Asano Y, Nakerakanti S, Smith E, Jablonska S, Blaszczyk M, ten Dijke P, Trojanowska M.

Arthritis Rheum. 2008 Aug;58(8):2528-37. doi: 10.1002/art.23698.


The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis.

Artlett CM, Sassi-Gaha S, Rieger JL, Boesteanu AC, Feghali-Bostwick CA, Katsikis PD.

Arthritis Rheum. 2011 Nov;63(11):3563-74. doi: 10.1002/art.30568.


Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway.

Bogatkevich GS, Tourkina E, Silver RM, Ludwicka-Bradley A.

J Biol Chem. 2001 Nov 30;276(48):45184-92. Epub 2001 Sep 28.

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