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Items: 1 to 20 of 95


Localization and quaternary structure of the PKA RIβ holoenzyme.

Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12443-8. doi: 10.1073/pnas.1209538109. Epub 2012 Jul 13.


The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.

Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor SS.

J Biol Chem. 2014 Oct 10;289(41):28505-12. doi: 10.1074/jbc.M114.584177. Epub 2014 Aug 11.


Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.

Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J.

J Mol Biol. 2004 Apr 9;337(5):1183-94.


Structure and allostery of the PKA RIIβ tetrameric holoenzyme.

Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS.

Science. 2012 Feb 10;335(6069):712-6. doi: 10.1126/science.1213979.


Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs.

Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS.

ACS Chem Biol. 2013 Oct 18;8(10):2164-72. doi: 10.1021/cb400247t. Epub 2013 Sep 10.


Identification of cAMP-dependent protein kinase holoenzymes in preantral- and preovulatory-follicle-enriched ovaries, and their association with A-kinase-anchoring proteins.

Carr DW, Cutler RE Jr, Cottom JE, Salvador LM, Fraser ID, Scott JD, Hunzicker-Dunn M.

Biochem J. 1999 Dec 1;344 Pt 2:613-23.


Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering.

Cheng CY, Yang J, Taylor SS, Blumenthal DK.

J Biol Chem. 2009 Dec 18;284(51):35916-25. doi: 10.1074/jbc.M109.059493. Epub .


The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II.

Ventra C, Porcellini A, Feliciello A, Gallo A, Paolillo M, Mele E, Avvedimento VE, Schettini G.

J Neurochem. 1996 Apr;66(4):1752-61.


Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain.

Mucignat-Caretta C, Caretta A.

J Neurocytol. 2001 Nov;30(11):885-94.


An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.

Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS.

Structure. 2015 Sep 1;23(9):1563-72. doi: 10.1016/j.str.2015.07.007. Epub 2015 Aug 13.


Differential effects of substrate on type I and type II PKA holoenzyme dissociation.

Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J.

Biochemistry. 2004 May 18;43(19):5629-36.


PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.

Wu J, Brown SH, von Daake S, Taylor SS.

Science. 2007 Oct 12;318(5848):274-9.


R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.

Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS.

J Mol Biol. 2007 Nov 23;374(2):487-99. Epub 2007 Sep 20.


Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures.

Brown SH, Wu J, Kim C, Alberto K, Taylor SS.

J Mol Biol. 2009 Nov 13;393(5):1070-82. doi: 10.1016/j.jmb.2009.09.014. Epub 2009 Sep 11.


The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding.

Vigil D, Blumenthal DK, Taylor SS, Trewhella J.

J Biol Chem. 2005 Oct 21;280(42):35521-7. Epub 2005 Aug 17.


Characterization of in-vitro-translated human regulatory and catalytic subunits of cAMP-dependent protein kinases.

Foss KB, Landmark B, Skålhegg BS, Taskén K, Jellum E, Hansson V, Jahnsen T.

Eur J Biochem. 1994 Feb 15;220(1):217-23.

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