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Items: 1 to 20 of 107


Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.

Peters HL, Tuli A, Wang X, Liu C, Pan Z, Ouellette MM, Hollingsworth MA, Macdonald RG, Solheim JC.

Int J Oncol. 2012 Oct;41(4):1464-74. doi: 10.3892/ijo.2012.1553. Epub 2012 Jul 13.


Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.

Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF.

PLoS One. 2011;6(6):e21337. doi: 10.1371/journal.pone.0021337. Epub 2011 Jun 17.


Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases.

Endres K, Postina R, Schroeder A, Mueller U, Fahrenholz F.

FEBS J. 2005 Nov;272(22):5808-20.


Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.

Adlerz L, Beckman M, Holback S, Tehranian R, Cortés Toro V, Iverfeldt K.

Brain Res Mol Brain Res. 2003 Nov 6;119(1):62-72.


Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells.

Woods NK, Padmanabhan J.

J Biol Chem. 2013 Oct 18;288(42):30114-24. doi: 10.1074/jbc.M113.459255. Epub 2013 Sep 10.


beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.

Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM.

FEBS J. 2010 Mar;277(6):1503-18. doi: 10.1111/j.1742-4658.2010.07579.x. Epub 2010 Feb 15.


Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.

Venkataramani V, Rossner C, Iffland L, Schweyer S, Tamboli IY, Walter J, Wirths O, Bayer TA.

J Biol Chem. 2010 Apr 2;285(14):10678-89. doi: 10.1074/jbc.M109.057836. Epub 2010 Feb 9.


An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM.

Biochemistry. 2009 Nov 24;48(46):10894-904. doi: 10.1021/bi901237k.


Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.

Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Müller U, Barde YA, Bibel M.

Stem Cells. 2008 Aug;26(8):2153-63. doi: 10.1634/stemcells.2008-0010. Epub 2008 Jun 5.


Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.

Jacobsen KT, Adlerz L, Multhaup G, Iverfeldt K.

J Biol Chem. 2010 Apr 2;285(14):10223-31. doi: 10.1074/jbc.M109.038224. Epub 2010 Feb 5.


Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage.

Takei N, Sobu Y, Kimura A, Urano S, Piao Y, Araki Y, Taru H, Yamamoto T, Hata S, Nakaya T, Suzuki T.

J Biol Chem. 2015 Jan 9;290(2):987-95. doi: 10.1074/jbc.M114.599852. Epub 2014 Nov 18.


Similar alternative splicing of a non-homologous domain in beta A4-amyloid protein precursor-like proteins.

Sandbrink R, Masters CL, Beyreuther K.

J Biol Chem. 1994 May 13;269(19):14227-34.


APP gene family. Alternative splicing generates functionally related isoforms.

Sandbrink R, Masters CL, Beyreuther K.

Ann N Y Acad Sci. 1996 Jan 17;777:281-7.


MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2.

Liang C, Zhu H, Xu Y, Huang L, Ma C, Deng W, Liu Y, Qin C.

Brain Res. 2012 May 21;1455:103-13. doi: 10.1016/j.brainres.2011.10.051. Epub 2011 Nov 4.


Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rülicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Müller U.

J Neurosci. 2000 Nov 1;20(21):7951-63.


A disintegrin and metalloprotease 10 activity sheds the ectodomain of the amyloid precursor-like protein 2 and regulates protein expression in proximal tubule cells.

Cong R, Li Y, Biemesderfer D.

Am J Physiol Cell Physiol. 2011 Jun;300(6):C1366-74. doi: 10.1152/ajpcell.00451.2010. Epub 2011 Feb 16.


Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.

White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R.

Brain Res. 2003 Mar 21;966(2):231-44.

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