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22796241,20381492,23311449,19187869,28404133,18663260,22626879,26216905,22659518,20185191,23545507,21205143,24628837,23376799,22098411,15962291,25434315,29758333,19550344,19187868,21742840,25371014,18662610,19567021,17854030,18578990,29378197,19795617,23123221,18491273,21503940,22267471,21623676,19207976,26361374,21205145,19052126,27789659,25884105,24251783,19719911,19637288,21555812,17713154,18697210,21692935,18081660,23286859,21311107,26853169,19231002,25834801,16788215,20546437,20562676,21940383,18221300,19697400,25939541,19236641,17561304,23588725,17400303,18324666,31082998,25176615,22506552,19231017,17988233,22966125,21549152,16842445,21503943,25589833,24766327,24905586,11124848,20185198,27639844,21793018,25131947,18343270,17567633,22707082,23237254,25825194,22582839,22195605,25024631,24316031,23744810,20825624,27455288,23286857,23219442,24773272,32211776,31884016,31701544,22326467,24373086,16595637,23909265,24373088,25769595,17318855,25312649,18572757,25917965,23971933,25323305,25309066,19581770,30930022,21718667,23090000,27121321,20888661,21198707,19852523,25529094,26151841,28696237,20403388,16573788,24373092,16506363,28317397,24909454,28345181,23619252,30428845,29427489,27027237,24814578,25034489,29309050,23627028,17515708,26927386,18816503,29902645,26840752,23730844,20890947,30497844,17983813,25034491,31730789,24089225,17184802,27074254,22180061,35180213,32329638,33437904,34558833,31499130,25274427,21591432,32854335,27528410,27919846,19482255,23905812,23326119,9727065,24777553,23905815,24417264,14647052,27435683,29740199,29862225,26493847,29181338,22726382,23519135,25178562,27288655,26574149,32613672,21550145,24592546,23905814,19320233,20449785,21205142,29156046,16915205,29156047,30037184,35363817,21565753,23749668,23639914,29498078,25529097,31529730,25052517,27609808,23735916,25424771,24797262,30702196,23905813,17287266,32302614,17924445,27788731,32188424,21307624,29715359,24555998,31324231,26263973,28521640,24876747,26621908,25460550,24376343,29055985,25752878,25034483,21682661,31323705,35224746,23103614,28512353,30008589,25429051,24118072,26209840,23344522,25481755,20483498,31982607,28746158,33009569,26742490,26582959,26738784,31266626,26505119,26548241,18373730,25014234,25402626,26931636,20842822,17917394,20973680,32604147,28427875,23749672,23798667,33711337,23897861,32209606,26381998,21305387,22694205,25049205,29803607,29315722,26491030,25308178,29471497,24583753,27044771,28827021,25640173,36963665,23627855,24812303,18166356,25869609,20960376,24961506,18167643,25611586,25537961,22523569,19461528,21964179,32029790,24716736,31667945,26526193,32061650,26725903,29082648,31765554,24580046,26924524,34275138,28052634,19243002,24704525,30187603,36840474,25861877,35589248,35714812,32638357,35889747,26228369,12971971,28211135,31765555,27026375,12081605,28581155,30826436,30471842,25034492,21321415,23286863,32093411,24747918,29577360,37026760,25892855,31941235,28951229,19072366,15482237,28749433,16810755,26703566,24846794,11169072,23744559,26416327,28521532,29761292,25499689,20650779,29268704,27084032,25968473,27262164,30518652,21544586,28575292,28052622,29079285,21147914,35458431,26194746,26152631,26936920,29156048,29393485,23749669,15494540,36146665,15192804,33234774,30818909,17489531,29734472,22326017,35504443,31086463,22032527,26420956,25788374,35810930,30801868,19443071,29170915,20669138,26684441,21692940,27302653,24231289,36366502,32417895,26476376,25645624,26732483,27577976,21423260,37001946,27270043,32852825,29491685,27210776,31244857,26658683,33979951,23750252,31323381,24804176,30415392,34931674,28292309,23164603,32668074,21320337,34272650,32852824,30731195,36732913,22905219,30907080,22541703,28629790,24394187,19346146,30579376,36546708,25892477,28494575,29309052,31278760,35120358,34768018,34281294,26052395,19951307,26423112,23826307,29752943,32077597,31635465,15606611,15453296,23423734,34583016,35181627,31608071,20304175,33685074,23886003,34661089,20425486,24914334,26428923,28774410,36417889,31177657,18505168,25016223,26752166,36045503,34207487,31941249,28297788,25531375,36466821,32911898,34846093,31306800,26363922,31805583,35045628,32363582,23660419,35963549,35458387,35716846,25535101,22016585,34508869,27318098,32770836,36519892,27084039,12296860,23543314,24162592,35045629,24037945,12871214,30869285,30415490,29065733,25193323,25834800,25658547,36382358,32508804,22176139,30260401,31254482,26095852,28778687,28239880,34464721,26640332,34371536,36655304,17408658,23776577,25699376,25772035,29948568,29555628,19900950,22072755,33418145,25418467,33401245,32687164,32433984,37137845,27665100,34227927,30737354,23546558,29216251,33043509,36774930,18240884,23391846,27547127,33090882,32810321,18240883,18572428,23783238,24976111,26150256,18570752,34392744,26524369,23468504,26569026,27693161,34894108,23707367,28774412,23852305,30168616,34887634,26854115,36423233,33722684,35485347,28792537,31608211,22737674,31765828,34743340,33550705,35594553,29220492,28661190,21307625,24984335,31840863,31195619,23581572,364669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875 results

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Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.

Boni C, Laccabue D, Lampertico P, Giuberti T, Viganò M, Schivazappa S, Alfieri A, Pesci M, Gaeta GB, Brancaccio G, Colombo M, Missale G, Ferrari C. Boni C, et al. Gastroenterology. 2012 Oct;143(4):963-73.e9. doi: 10.1053/j.gastro.2012.07.014. Epub 2012 Jul 14. Gastroenterology. 2012. PMID: 22796241

Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B.

Reijnders JG, Perquin MJ, Zhang N, Hansen BE, Janssen HL. Reijnders JG, et al. Gastroenterology. 2010 Aug;139(2):491-8. doi: 10.1053/j.gastro.2010.03.059. Epub 2010 Apr 8. Gastroenterology. 2010. PMID: 20381492

Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D.

Boglione L, D'Avolio A, Cariti G, Gregori G, Burdino E, Baietto L, Cusato J, Ghisetti V, De Rosa FG, Di Perri G. Boglione L, et al. Liver Int. 2013 Apr;33(4):580-5. doi: 10.1111/liv.12091. Epub 2013 Jan 14. Liver Int. 2013. PMID: 23311449

Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.

Buster EH, Schalm SW, Janssen HL. Buster EH, et al. Best Pract Res Clin Gastroenterol. 2008;22(6):1093-108. doi: 10.1016/j.bpg.2008.11.007. Best Pract Res Clin Gastroenterol. 2008. PMID: 19187869 Review.

Effect on HBs antigen clearance of addition of pegylated interferon alfa-2a to nucleos(t)ide analogue therapy versus nucleos(t)ide analogue therapy alone in patients with HBe antigen-negative chronic hepatitis B and sustained undetectable plasma hepatitis B virus DNA: a randomised, controlled, open-label trial.

Bourlière M, Rabiega P, Ganne-Carrie N, Serfaty L, Marcellin P, Barthe Y, Thabut D, Guyader D, Hezode C, Picon M, Causse X, Leroy V, Bronowicki JP, Carrieri P, Riachi G, Rosa I, Attali P, Molina JM, Bacq Y, Tran A, Grangé JD, Zoulim F, Fontaine H, Alric L, Bertucci I, Bouvier-Alias M, Carrat F; ANRS HB06 PEGAN Study Group. Bourlière M, et al. Lancet Gastroenterol Hepatol. 2017 Mar;2(3):177-188. doi: 10.1016/S2468-1253(16)30189-3. Epub 2017 Jan 20. Lancet Gastroenterol Hepatol. 2017. PMID: 28404133 Free article. Clinical Trial.

Treatment of chronic hepatitis B virus infection - Dutch national guidelines.

Buster EH, van Erpecum KJ, Schalm SW, Zaaijer HL, Brouwer JT, Gelderblom HC, de Knegt RJ, Minke Bakker C, Reesink HW, Janssen HL; Netherlands Association of Gastroenterologists and Hepatologists. Buster EH, et al. Neth J Med. 2008 Jul-Aug;66(7):292-306. Neth J Med. 2008. PMID: 18663260 Free article. Review.

Regulatory T-cell responses in chronic hepatitis B patients treated with nucleos(t)ide analogs compared with healthy subjects and untreated infected individuals.

Chen LY, Zhu LY, Yang BS, Bi MR, Yan BZ, Wang W, Ma YJ. Chen LY, et al. Hepatogastroenterology. 2012 Nov-Dec;59(120):2582-6. doi: 10.5754/hge12287. Hepatogastroenterology. 2012. PMID: 22626879 Clinical Trial.

Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues.

Jansen L, Kootstra NA, van Dort KA, Takkenberg RB, Reesink HW, Zaaijer HL. Jansen L, et al. J Infect Dis. 2016 Jan 15;213(2):224-32. doi: 10.1093/infdis/jiv397. Epub 2015 Jul 27. J Infect Dis. 2016. PMID: 26216905 Clinical Trial.

Long-term continuous entecavir therapy in nucleos(t)ide-naïve chronic hepatitis B patients.

Ono A, Suzuki F, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Suzuki Y, Saitou S, Arase Y, Ikeda K, Kobayashi M, Watahiki S, Mineta R, Kumada H. Ono A, et al. J Hepatol. 2012 Sep;57(3):508-14. doi: 10.1016/j.jhep.2012.04.037. Epub 2012 May 30. J Hepatol. 2012. PMID: 22659518

Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues.

Reijnders JG, Deterding K, Petersen J, Zoulim F, Santantonio T, Buti M, van Bömmel F, Hansen BE, Wedemeyer H, Janssen HL; VIRGIL Surveillance Study Group. Reijnders JG, et al. J Hepatol. 2010 Apr;52(4):493-500. doi: 10.1016/j.jhep.2010.01.012. Epub 2010 Feb 4. J Hepatol. 2010. PMID: 20185191 Clinical Trial.

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