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Results: 1 to 20 of 103

1.

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.

Müller S, Sanders DA, Di Antonio M, Matsis S, Riou JF, Rodriguez R, Balasubramanian S.

Org Biomol Chem. 2012 Aug 28;10(32):6537-46. doi: 10.1039/c2ob25830g. Epub 2012 Jul 13.

PMID:
22790277
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.

Rodriguez R, Miller KM, Forment JV, Bradshaw CR, Nikan M, Britton S, Oelschlaegel T, Xhemalce B, Balasubramanian S, Jackson SP.

Nat Chem Biol. 2012 Feb 5;8(3):301-10. doi: 10.1038/nchembio.780.

PMID:
22306580
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

McLuckie KI, Di Antonio M, Zecchini H, Xian J, Caldas C, Krippendorff BF, Tannahill D, Lowe C, Balasubramanian S.

J Am Chem Soc. 2013 Jul 3;135(26):9640-3. doi: 10.1021/ja404868t. Epub 2013 Jun 25.

PMID:
23782415
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands.

Collie GW, Promontorio R, Hampel SM, Micco M, Neidle S, Parkinson GN.

J Am Chem Soc. 2012 Feb 8;134(5):2723-31. doi: 10.1021/ja2102423. Epub 2012 Jan 31.

PMID:
22280460
[PubMed - indexed for MEDLINE]
5.

G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.

Huang FC, Chang CC, Lou PJ, Kuo IC, Chien CW, Chen CT, Shieh FY, Chang TC, Lin JJ.

Mol Cancer Res. 2008 Jun;6(6):955-64. doi: 10.1158/1541-7786.MCR-07-0260. Epub 2008 May 30.

PMID:
18515756
[PubMed - indexed for MEDLINE]
Free Article
6.

Small-molecule-mediated G-quadruplex isolation from human cells.

Müller S, Kumari S, Rodriguez R, Balasubramanian S.

Nat Chem. 2010 Dec;2(12):1095-8. doi: 10.1038/nchem.842. Epub 2010 Oct 10.

PMID:
21107376
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.

Castor KJ, Mancini J, Fakhoury J, Weill N, Kieltyka R, Englebienne P, Avakyan N, Mittermaier A, Autexier C, Moitessier N, Sleiman HF.

ChemMedChem. 2012 Jan 2;7(1):85-94. doi: 10.1002/cmdc.201100453. Epub 2011 Nov 3.

PMID:
22052801
[PubMed - indexed for MEDLINE]
8.

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.

Murat P, Gormally MV, Sanders D, Di Antonio M, Balasubramanian S.

Chem Commun (Camb). 2013 Oct 4;49(76):8453-5. doi: 10.1039/c3cc44737e.

PMID:
23949446
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Effects of a halogenated G-quadruplex ligand from the pyridine dicarboxamide series on the terminal sequence of XpYp telomere in HT1080 cells.

Sidibe A, Hamon F, Largy E, Gomez D, Teulade-Fichou MP, Trentesaux C, Riou JF.

Biochimie. 2012 Dec;94(12):2559-68. doi: 10.1016/j.biochi.2012.07.003. Epub 2012 Jul 14.

PMID:
22796264
[PubMed - indexed for MEDLINE]
10.

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.

Koirala D, Dhakal S, Ashbridge B, Sannohe Y, Rodriguez R, Sugiyama H, Balasubramanian S, Mao H.

Nat Chem. 2011 Aug 28;3(10):782-7. doi: 10.1038/nchem.1126.

PMID:
21941250
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence.

Di Leva FS, Zizza P, Cingolani C, D'Angelo C, Pagano B, Amato J, Salvati E, Sissi C, Pinato O, Marinelli L, Cavalli A, Cosconati S, Novellino E, Randazzo A, Biroccio A.

J Med Chem. 2013 Dec 12;56(23):9646-54. doi: 10.1021/jm401185b. Epub 2013 Nov 27.

PMID:
24256368
[PubMed - indexed for MEDLINE]
12.

Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes.

Sparapani S, Haider SM, Doria F, Gunaratnam M, Neidle S.

J Am Chem Soc. 2010 Sep 8;132(35):12263-72. doi: 10.1021/ja1003944.

PMID:
20718414
[PubMed - indexed for MEDLINE]
13.

Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.

Cosconati S, Rizzo A, Trotta R, Pagano B, Iachettini S, De Tito S, Lauri I, Fotticchia I, Giustiniano M, Marinelli L, Giancola C, Novellino E, Biroccio A, Randazzo A.

J Med Chem. 2012 Nov 26;55(22):9785-92. doi: 10.1021/jm301019w. Epub 2012 Oct 18.

PMID:
23057850
[PubMed - indexed for MEDLINE]
14.

Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.

Laronze-Cochard M, Kim YM, Brassart B, Riou JF, Laronze JY, Sapi J.

Eur J Med Chem. 2009 Oct;44(10):3880-8. doi: 10.1016/j.ejmech.2009.04.021. Epub 2009 Apr 22.

PMID:
19467742
[PubMed - indexed for MEDLINE]
15.

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Moore MJ, Schultes CM, Cuesta J, Cuenca F, Gunaratnam M, Tanious FA, Wilson WD, Neidle S.

J Med Chem. 2006 Jan 26;49(2):582-99.

PMID:
16420044
[PubMed - indexed for MEDLINE]
16.

Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer.

Folini M, Pivetta C, Zagotto G, De Marco C, Palumbo M, Zaffaroni N, Sissi C.

Biochem Pharmacol. 2010 Jun 15;79(12):1781-90. doi: 10.1016/j.bcp.2010.02.018. Epub 2010 Mar 3.

PMID:
20206144
[PubMed - indexed for MEDLINE]
17.

DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity.

Yu H, Zhao C, Chen Y, Fu M, Ren J, Qu X.

J Med Chem. 2010 Jan 14;53(1):492-8. doi: 10.1021/jm9014795.

PMID:
19911822
[PubMed - indexed for MEDLINE]
18.

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands.

Riou JF, Guittat L, Mailliet P, Laoui A, Renou E, Petitgenet O, Mégnin-Chanet F, Hélène C, Mergny JL.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2672-7. Epub 2002 Feb 19.

PMID:
11854467
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

An evaluation cascade for G-quadruplex telomere targeting agents in human cancer cells.

Gunaratnam M, Neidle S.

Methods Mol Biol. 2010;613:303-13. doi: 10.1007/978-1-60327-418-0_19.

PMID:
19997892
[PubMed - indexed for MEDLINE]
20.

Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells.

Micco M, Collie GW, Dale AG, Ohnmacht SA, Pazitna I, Gunaratnam M, Reszka AP, Neidle S.

J Med Chem. 2013 Apr 11;56(7):2959-74. doi: 10.1021/jm301899y. Epub 2013 Apr 2.

PMID:
23514618
[PubMed - indexed for MEDLINE]

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