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Items: 1 to 20 of 106

1.

Promoter methylation confers kidney-specific expression of the Klotho gene.

Azuma M, Koyama D, Kikuchi J, Yoshizawa H, Thasinas D, Shiizaki K, Kuro-o M, Furukawa Y, Kusano E.

FASEB J. 2012 Oct;26(10):4264-74. doi: 10.1096/fj.12-211631. Epub 2012 Jul 10.

2.

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma.

Lee J, Jeong DJ, Kim J, Lee S, Park JH, Chang B, Jung SI, Yi L, Han Y, Yang Y, Kim KI, Lim JS, Yang I, Jeon S, Bae DH, Kim CJ, Lee MS.

Mol Cancer. 2010 May 18;9:109. doi: 10.1186/1476-4598-9-109.

3.

Epigenetic silencing of the tumor suppressor klotho in human breast cancer.

Rubinek T, Shulman M, Israeli S, Bose S, Avraham A, Zundelevich A, Evron E, Gal-Yam EN, Kaufman B, Wolf I.

Breast Cancer Res Treat. 2012 Jun;133(2):649-57. doi: 10.1007/s10549-011-1824-4. Epub 2011 Oct 22.

PMID:
22042362
4.

Establishment of a cell-based assay to screen regulators for Klotho gene promoter.

Xu ZL, Gao H, Ou-Yang KQ, Cai SX, Hu YH.

Acta Pharmacol Sin. 2004 Sep;25(9):1165-70.

5.

Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma.

Xie B, Zhou J, Yuan L, Ren F, Liu DC, Li Q, Shu G.

Hum Pathol. 2013 May;44(5):795-801. doi: 10.1016/j.humpath.2012.07.023. Epub 2012 Oct 31.

PMID:
23123137
6.

Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.

Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ.

Tumour Biol. 2011 Aug;32(4):729-35. doi: 10.1007/s13277-011-0174-5. Epub 2011 Apr 27.

PMID:
21523445
7.

Elevated Klotho promoter methylation is associated with severity of chronic kidney disease.

Chen J, Zhang X, Zhang H, Lin J, Zhang C, Wu Q, Ding X.

PLoS One. 2013 Nov 5;8(11):e79856. doi: 10.1371/journal.pone.0079856. eCollection 2013.

8.
9.

The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.

Fish JE, Matouk CC, Rachlis A, Lin S, Tai SC, D'Abreo C, Marsden PA.

J Biol Chem. 2005 Jul 1;280(26):24824-38. Epub 2005 May 3.

10.

[DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance].

Gan LH, Pan J, Chen SJ, Zhong J, Wang LJ.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 May;40(3):309-14. Chinese.

PMID:
21671493
11.

Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice.

Sastre C, Rubio-Navarro A, Buendía I, Gómez-Guerrero C, Blanco J, Mas S, Egido J, Blanco-Colio LM, Ortiz A, Moreno JA.

PLoS One. 2013 Dec 30;8(12):e83713. doi: 10.1371/journal.pone.0083713. eCollection 2013.

12.

Promoter methylation and age-related downregulation of Klotho in rhesus monkey.

King GD, Rosene DL, Abraham CR.

Age (Dordr). 2012 Dec;34(6):1405-19. doi: 10.1007/s11357-011-9315-4. Epub 2011 Sep 16.

13.

Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.

Yuan J, Luo RZ, Fujii S, Wang L, Hu W, Andreeff M, Pan Y, Kadota M, Oshimura M, Sahin AA, Issa JP, Bast RC Jr, Yu Y.

Cancer Res. 2003 Jul 15;63(14):4174-80.

14.

The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation.

Chan Y, Fish JE, D'Abreo C, Lin S, Robb GB, Teichert AM, Karantzoulis-Fegaras F, Keightley A, Steer BM, Marsden PA.

J Biol Chem. 2004 Aug 13;279(33):35087-100. Epub 2004 Jun 4.

15.

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice.

Sato S, Kawamata Y, Takahashi A, Imai Y, Hanyu A, Okuma A, Takasugi M, Yamakoshi K, Sorimachi H, Kanda H, Ishikawa Y, Sone S, Nishioka Y, Ohtani N, Hara E.

Nat Commun. 2015 Apr 29;6:7035. doi: 10.1038/ncomms8035.

16.

Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1.

Choi BH, Kim CG, Lim Y, Lee YH, Shin SY.

Gene. 2010 Jan 15;450(1-2):121-7. doi: 10.1016/j.gene.2009.11.004. Epub .

PMID:
19913601
17.

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549.

Chen B, Wang X, Zhao W, Wu J.

J Exp Clin Cancer Res. 2010 Jul 19;29:99. doi: 10.1186/1756-9966-29-99.

20.

The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice.

Chen TH, Kuro-O M, Chen CH, Sue YM, Chen YC, Wu HH, Cheng CY.

Eur J Pharmacol. 2013 Jan 5;698(1-3):67-73. doi: 10.1016/j.ejphar.2012.09.032. Epub 2012 Oct 3.

PMID:
23041151
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