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Results: 1 to 20 of 99

1.

Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and in vivo bioavailability.

Miller MA, Khan TA, Kaczorowski KJ, Wilson BK, Dinin AK, Borwankar AU, Rodrigues MA, Truskett TM, Johnston KP, Maynard JA.

J Pharm Sci. 2012 Oct;101(10):3763-78. doi: 10.1002/jps.23256. Epub 2012 Jul 6.

PMID:
22777686
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Concentrated dispersions of equilibrium protein nanoclusters that reversibly dissociate into active monomers.

Johnston KP, Maynard JA, Truskett TM, Borwankar AU, Miller MA, Wilson BK, Dinin AK, Khan TA, Kaczorowski KJ.

ACS Nano. 2012 Feb 28;6(2):1357-69. doi: 10.1021/nn204166z. Epub 2012 Jan 30.

PMID:
22260218
[PubMed - indexed for MEDLINE]
3.

Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution.

Liu J, Nguyen MD, Andya JD, Shire SJ.

J Pharm Sci. 2005 Sep;94(9):1928-40. Erratum in: J Pharm Sci. 2006 Jan;95(1):234-5.

PMID:
16052543
[PubMed - indexed for MEDLINE]
4.

Crystalline monoclonal antibodies for subcutaneous delivery.

Yang MX, Shenoy B, Disttler M, Patel R, McGrath M, Pechenov S, Margolin AL.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6934-9. Epub 2003 Jun 2.

PMID:
12782786
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.

Salinas BA, Sathish HA, Bishop SM, Harn N, Carpenter JF, Randolph TW.

J Pharm Sci. 2010 Jan;99(1):82-93. doi: 10.1002/jps.21797.

PMID:
19475558
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Prevention of stirring-induced microparticle formation in monoclonal antibody solutions.

Ishikawa T, Kobayashi N, Osawa C, Sawa E, Wakamatsu K.

Biol Pharm Bull. 2010;33(6):1043-6.

PMID:
20522974
[PubMed - indexed for MEDLINE]
Free Article
7.

Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates.

Sule SV, Dickinson CD, Lu J, Chow CK, Tessier PM.

Mol Pharm. 2013 Apr 1;10(4):1322-31. doi: 10.1021/mp300524x. Epub 2013 Mar 8.

PMID:
23383873
[PubMed - indexed for MEDLINE]
8.

Application of melt extrusion in the development of a physically and chemically stable high-energy amorphous solid dispersion of a poorly water-soluble drug.

Lakshman JP, Cao Y, Kowalski J, Serajuddin AT.

Mol Pharm. 2008 Nov-Dec;5(6):994-1002. doi: 10.1021/mp8001073.

PMID:
19434852
[PubMed - indexed for MEDLINE]
9.

Viscosity of concentrated therapeutic protein compositions.

Jezek J, Rides M, Derham B, Moore J, Cerasoli E, Simler R, Perez-Ramirez B.

Adv Drug Deliv Rev. 2011 Oct;63(13):1107-17. doi: 10.1016/j.addr.2011.09.008. Review.

PMID:
22014592
[PubMed - indexed for MEDLINE]
10.

Structure-activity relationship for hydrophobic salts as viscosity-lowering excipients for concentrated solutions of monoclonal antibodies.

Guo Z, Chen A, Nassar RA, Helk B, Mueller C, Tang Y, Gupta K, Klibanov AM.

Pharm Res. 2012 Nov;29(11):3102-9. doi: 10.1007/s11095-012-0802-9. Epub 2012 Jun 13.

PMID:
22692671
[PubMed - indexed for MEDLINE]
11.

Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal antibodies.

Gibson TJ, Mccarty K, Mcfadyen IJ, Cash E, Dalmonte P, Hinds KD, Dinerman AA, Alvarez JC, Volkin DB.

J Pharm Sci. 2011 Mar;100(3):1009-21. doi: 10.1002/jps.22350. Epub 2010 Oct 25.

PMID:
21280052
[PubMed - indexed for MEDLINE]
12.

The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo.

Kennel SJ, Woodward JD, Rondinone AJ, Wall J, Huang Y, Mirzadeh S.

Nucl Med Biol. 2008 May;35(4):501-14. doi: 10.1016/j.nucmedbio.2008.02.001. Epub 2008 Apr 3.

PMID:
18482688
[PubMed - indexed for MEDLINE]
13.

Anticancer efficacy, tissue distribution and blood pharmacokinetics of surface modified nanocarrier containing melphalan.

Rajpoot P, Bali V, Pathak K.

Int J Pharm. 2012 Apr 15;426(1-2):219-30. doi: 10.1016/j.ijpharm.2012.01.027. Epub 2012 Jan 24.

PMID:
22301424
[PubMed - indexed for MEDLINE]
14.

High bioavailability from nebulized itraconazole nanoparticle dispersions with biocompatible stabilizers.

Yang W, Tam J, Miller DA, Zhou J, McConville JT, Johnston KP, Williams RO 3rd.

Int J Pharm. 2008 Sep 1;361(1-2):177-88. doi: 10.1016/j.ijpharm.2008.05.003. Epub 2008 May 14.

PMID:
18556158
[PubMed - indexed for MEDLINE]
15.

Investigating high-concentration monoclonal antibody powder suspension in nonaqueous suspension vehicles for subcutaneous injection.

Bowen M, Armstrong N, Maa YF.

J Pharm Sci. 2012 Dec;101(12):4433-43. doi: 10.1002/jps.23324. Epub 2012 Sep 21.

PMID:
23001898
[PubMed - indexed for MEDLINE]
16.

High-dose monoclonal antibodies via the subcutaneous route: challenges and technical solutions, an industry perspective.

Narasimhan C, Mach H, Shameem M.

Ther Deliv. 2012 Jul;3(7):889-900. Review.

PMID:
22900469
[PubMed - indexed for MEDLINE]
17.

Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process.

Salmaso S, Elvassore N, Bertucco A, Caliceti P.

J Pharm Sci. 2009 Feb;98(2):640-50. doi: 10.1002/jps.21434.

PMID:
18484622
[PubMed - indexed for MEDLINE]
18.

Viscosity behavior of high-concentration protein mixtures.

Galush WJ, Le LN, Moore JM.

J Pharm Sci. 2012 Mar;101(3):1012-20. doi: 10.1002/jps.23002. Epub 2011 Dec 13.

PMID:
22170353
[PubMed - indexed for MEDLINE]
19.

Effect of sugar molecules on the viscosity of high concentration monoclonal antibody solutions.

He F, Woods CE, Litowski JR, Roschen LA, Gadgil HS, Razinkov VI, Kerwin BA.

Pharm Res. 2011 Jul;28(7):1552-60. doi: 10.1007/s11095-011-0388-7. Epub 2011 May 15.

PMID:
21573867
[PubMed - indexed for MEDLINE]
20.

Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process.

Tessier PM, Wu J, Dickinson CD.

Expert Opin Drug Deliv. 2014 Apr;11(4):461-5. doi: 10.1517/17425247.2014.876989. Epub 2014 Jan 21.

PMID:
24444112
[PubMed - indexed for MEDLINE]
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