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Results: 1 to 20 of 125

1.

Investigative safety science as a competitive advantage for Pharma.

Moggs J, Moulin P, Pognan F, Brees D, Leonard M, Busch S, Cordier A, Heard DJ, Kammüller M, Merz M, Bouchard P, Chibout SD.

Expert Opin Drug Metab Toxicol. 2012 Sep;8(9):1071-82. doi: 10.1517/17425255.2012.693914. Epub 2012 Jul 7. Review.

PMID:
22769724
[PubMed - indexed for MEDLINE]
2.

Drug safety testing paradigm, current progress and future challenges: an overview.

Ahuja V, Sharma S.

J Appl Toxicol. 2014 Jun;34(6):576-94. doi: 10.1002/jat.2935. Epub 2013 Oct 29.

PMID:
24777877
[PubMed - in process]
3.

The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity.

Amacher DE.

Toxicol Appl Pharmacol. 2010 May 15;245(1):134-42. doi: 10.1016/j.taap.2010.02.011. Epub 2010 Feb 26. Review.

PMID:
20219512
[PubMed - indexed for MEDLINE]
4.

Informed toxicity assessment in drug discovery: systems-based toxicology.

Mayne JT, Ku WW, Kennedy SP.

Curr Opin Drug Discov Devel. 2006 Jan;9(1):75-83. Review.

PMID:
16445119
[PubMed - indexed for MEDLINE]
5.

Exploratory drug safety: a discovery strategy to reduce attrition in development.

Bass AS, Cartwright ME, Mahon C, Morrison R, Snyder R, McNamara P, Bradley P, Zhou YY, Hunter J.

J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):69-78. doi: 10.1016/j.vascn.2009.04.194. Epub 2009 May 5. Review.

PMID:
19422924
[PubMed - indexed for MEDLINE]
6.

Future of toxicology--mechanisms of toxicity and drug safety: where do we go from here?

Stevens JL.

Chem Res Toxicol. 2006 Nov;19(11):1393-401. Review.

PMID:
17112225
[PubMed - indexed for MEDLINE]
7.

Computational science in drug metabolism and toxicology.

Valerio LG.

Expert Opin Drug Metab Toxicol. 2010 Jul;6(7):781-4. doi: 10.1517/17425255.2010.486789.

PMID:
20465524
[PubMed - indexed for MEDLINE]
9.

The new revolution in toxicology: the good, the bad, and the ugly.

Davis M, Boekelheide K, Boverhof DR, Eichenbaum G, Hartung T, Holsapple MP, Jones TW, Richard AM, Watkins PB.

Ann N Y Acad Sci. 2013 Mar;1278:11-24. doi: 10.1111/nyas.12086.

PMID:
23488558
[PubMed - indexed for MEDLINE]
10.

Advances in the development and use of human tissue-based techniques for drug toxicity testing.

Clotworthy M, Archibald K.

Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1155-69. doi: 10.1517/17425255.2013.802770. Epub 2013 May 20. Review.

PMID:
23687950
[PubMed - indexed for MEDLINE]
11.

The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates.

Kramer JA, Sagartz JE, Morris DL.

Nat Rev Drug Discov. 2007 Aug;6(8):636-49. Review.

PMID:
17643090
[PubMed - indexed for MEDLINE]
12.

Safety assessment of biotechnology-derived pharmaceuticals: ICH and beyond.

Serabian MA, Pilaro AM.

Toxicol Pathol. 1999 Jan-Feb;27(1):27-31. Review.

PMID:
10367669
[PubMed - indexed for MEDLINE]
Free Article
13.

[Development of antituberculous drugs: current status and future prospects].

Tomioka H, Namba K.

Kekkaku. 2006 Dec;81(12):753-74. Review. Japanese.

PMID:
17240921
[PubMed - indexed for MEDLINE]
14.

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

Laverty H, Benson C, Cartwright E, Cross M, Garland C, Hammond T, Holloway C, McMahon N, Milligan J, Park B, Pirmohamed M, Pollard C, Radford J, Roome N, Sager P, Singh S, Suter T, Suter W, Trafford A, Volders P, Wallis R, Weaver R, York M, Valentin J.

Br J Pharmacol. 2011 Jun;163(4):675-93. doi: 10.1111/j.1476-5381.2011.01255.x. Review.

PMID:
21306581
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009.

Bushnell PJ, Kavlock RJ, Crofton KM, Weiss B, Rice DC.

Neurotoxicol Teratol. 2010 May-Jun;32(3):313-28. doi: 10.1016/j.ntt.2010.02.002. Epub 2010 Feb 17.

PMID:
20171276
[PubMed - indexed for MEDLINE]
16.

The role of early in vivo toxicity testing in drug discovery toxicology.

Fielden MR, Kolaja KL.

Expert Opin Drug Saf. 2008 Mar;7(2):107-10. doi: 10.1517/14740338.7.2.107 .

PMID:
18324874
[PubMed - indexed for MEDLINE]
17.

Dogs and monkeys in preclinical drug development: the challenge of reducing and replacing.

Pellegatti M.

Expert Opin Drug Metab Toxicol. 2013 Sep;9(9):1171-80. doi: 10.1517/17425255.2013.804061. Epub 2013 May 25. Review.

PMID:
23705836
[PubMed - indexed for MEDLINE]
18.

Removing obstacles in neuroscience drug discovery: the future path for animal models.

Markou A, Chiamulera C, Geyer MA, Tricklebank M, Steckler T.

Neuropsychopharmacology. 2009 Jan;34(1):74-89. doi: 10.1038/npp.2008.173. Epub 2008 Oct 1. Review.

PMID:
18830240
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Toxicity testing in the 21st century: bringing the vision to life.

Andersen ME, Krewski D.

Toxicol Sci. 2009 Feb;107(2):324-30. doi: 10.1093/toxsci/kfn255. Epub 2008 Dec 12. Review.

PMID:
19074763
[PubMed - indexed for MEDLINE]
Free Article
20.

Computational systems biology and dose-response modeling in relation to new directions in toxicity testing.

Zhang Q, Bhattacharya S, Andersen ME, Conolly RB.

J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):253-76. doi: 10.1080/10937404.2010.483943.

PMID:
20574901
[PubMed - indexed for MEDLINE]

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