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Results: 1 to 20 of 96

1.

Mitochondrial dysfunction in pancreatic β cells.

Supale S, Li N, Brun T, Maechler P.

Trends Endocrinol Metab. 2012 Sep;23(9):477-87. doi: 10.1016/j.tem.2012.06.002. Epub 2012 Jul 4. Review.

PMID:
22766318
[PubMed - indexed for MEDLINE]
2.

Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells.

Lee JW, Kim WH, Lim JH, Song EH, Song J, Choi KY, Jung MH.

Cell Signal. 2009 Jan;21(1):69-78. doi: 10.1016/j.cellsig.2008.09.015. Epub 2008 Oct 7.

PMID:
18940247
[PubMed - indexed for MEDLINE]
3.

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

Li N, Frigerio F, Maechler P.

Biochem Soc Trans. 2008 Oct;36(Pt 5):930-4. doi: 10.1042/BST0360930. Review.

PMID:
18793163
[PubMed - indexed for MEDLINE]
4.

Mitochondrial damages and the regulation of insulin secretion.

Maechler P, de Andrade PB.

Biochem Soc Trans. 2006 Nov;34(Pt 5):824-7.

PMID:
17052207
[PubMed - indexed for MEDLINE]
5.

Role of mitochondria in beta-cell function and dysfunction.

Maechler P, Li N, Casimir M, Vetterli L, Frigerio F, Brun T.

Adv Exp Med Biol. 2010;654:193-216. doi: 10.1007/978-90-481-3271-3_9. Review.

PMID:
20217499
[PubMed - indexed for MEDLINE]
6.

The mitochondrial Atp8 mutation induces mitochondrial ROS generation, secretory dysfunction, and β-cell mass adaptation in conplastic B6-mtFVB mice.

Weiss H, Wester-Rosenloef L, Koch C, Koch F, Baltrusch S, Tiedge M, Ibrahim S.

Endocrinology. 2012 Oct;153(10):4666-76. Epub 2012 Aug 23.

PMID:
22919063
[PubMed - indexed for MEDLINE]
7.

Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

Li N, Stojanovski S, Maechler P.

Oxid Med Cell Longev. 2012;2012:740849. doi: 10.1155/2012/740849. Epub 2012 Sep 16. Review.

PMID:
23029600
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.

Wiederkehr A, Wollheim CB.

Cell Calcium. 2008 Jul;44(1):64-76. doi: 10.1016/j.ceca.2007.11.004. Epub 2008 Jan 8. Review.

PMID:
18191448
[PubMed - indexed for MEDLINE]
9.

Impairment of pancreatic β-cell function by chronic intermittent hypoxia.

Wang N, Khan SA, Prabhakar NR, Nanduri J.

Exp Physiol. 2013 Sep;98(9):1376-85. doi: 10.1113/expphysiol.2013.072454. Epub 2013 May 24.

PMID:
23709585
[PubMed - indexed for MEDLINE]
10.

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

Malmgren S, Nicholls DG, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H, Sharoyko VV.

J Biol Chem. 2009 Nov 20;284(47):32395-404. doi: 10.1074/jbc.M109.026708. Epub 2009 Sep 21.

PMID:
19797055
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.

Li N, Brun T, Cnop M, Cunha DA, Eizirik DL, Maechler P.

J Biol Chem. 2009 Aug 28;284(35):23602-12. doi: 10.1074/jbc.M109.024323. Epub 2009 Jun 22.

PMID:
19546218
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Molecular and metabolic evidence for mitochondrial defects associated with beta-cell dysfunction in a mouse model of type 2 diabetes.

Lu H, Koshkin V, Allister EM, Gyulkhandanyan AV, Wheeler MB.

Diabetes. 2010 Feb;59(2):448-59. doi: 10.2337/db09-0129. Epub 2009 Nov 10.

PMID:
19903739
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mitochondrial signals drive insulin secretion in the pancreatic β-cell.

Wiederkehr A, Wollheim CB.

Mol Cell Endocrinol. 2012 Apr 28;353(1-2):128-37. doi: 10.1016/j.mce.2011.07.016. Epub 2011 Jul 19. Review.

PMID:
21784130
[PubMed - indexed for MEDLINE]
14.

Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β-cells.

Gehrmann W, Elsner M, Lenzen S.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:149-58. doi: 10.1111/j.1463-1326.2010.01265.x. Review.

PMID:
21029312
[PubMed - indexed for MEDLINE]
15.

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M.

Free Radic Biol Med. 2007 Jan 1;42(1):64-78. Epub 2006 Sep 27.

PMID:
17157194
[PubMed - indexed for MEDLINE]
16.

Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways.

Tuo Y, Wang D, Li S, Chen C.

Endocrine. 2011 Apr;39(2):128-38. doi: 10.1007/s12020-010-9432-3. Epub 2010 Dec 15.

PMID:
21161439
[PubMed - indexed for MEDLINE]
17.

Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancreatic islets.

Graciano MF, Valle MM, Kowluru A, Curi R, Carpinelli AR.

Islets. 2011 Sep-Oct;3(5):213-23. Epub 2011 Sep 1. Review.

PMID:
21750413
[PubMed - indexed for MEDLINE]
Free Article
18.

Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration.

Roma LP, Pascal SM, Duprez J, Jonas JC.

Diabetologia. 2012 Aug;55(8):2226-37. doi: 10.1007/s00125-012-2581-6. Epub 2012 May 29.

PMID:
22643931
[PubMed - indexed for MEDLINE]
19.

Mitochondrial function and insulin secretion.

Maechler P.

Mol Cell Endocrinol. 2013 Oct 15;379(1-2):12-8. doi: 10.1016/j.mce.2013.06.019. Epub 2013 Jun 20. Review.

PMID:
23792187
[PubMed - indexed for MEDLINE]
20.

Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function.

Pi J, Collins S.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:141-8. doi: 10.1111/j.1463-1326.2010.01269.x. Review.

PMID:
21029311
[PubMed - indexed for MEDLINE]

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