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Items: 1 to 20 of 104

1.

Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor.

Strachan JP, Farias JJ, Zhang J, Caldwell WS, Bhatti BS.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5089-92. doi: 10.1016/j.bmcl.2012.05.108. Epub 2012 Jun 13.

PMID:
22749278
2.

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors.

Murineddu G, Murruzzu C, Curzu MM, Chelucci G, Gotti C, Gaimarri A, Legnani L, Toma L, Pinna GA.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6147-50. doi: 10.1016/j.bmcl.2008.10.002. Epub 2008 Oct 5.

PMID:
18938077
3.

Design, synthesis, and pharmacological characterization of novel spirocyclic quinuclidinyl-Δ2-isoxazoline derivatives as potent and selective agonists of α7 nicotinic acetylcholine receptors.

Dallanoce C, Magrone P, Matera C, Frigerio F, Grazioso G, De Amici M, Fucile S, Piccari V, Frydenvang K, Pucci L, Gotti C, Clementi F, De Micheli C.

ChemMedChem. 2011 May 2;6(5):889-903. doi: 10.1002/cmdc.201000514. Epub 2011 Mar 1.

PMID:
21365765
4.

[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.

Anderson DJ, Bunnelle W, Surber B, Du J, Surowy C, Tribollet E, Marguerat A, Bertrand D, Gopalakrishnan M.

J Pharmacol Exp Ther. 2008 Jan;324(1):179-87. Epub 2007 Oct 24.

5.

Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands.

Bhatti BS, Strachan JP, Breining SR, Miller CH, Tahiri P, Crooks PA, Deo N, Day CS, Caldwell WS.

J Org Chem. 2008 May 2;73(9):3497-507. doi: 10.1021/jo800028q. Epub 2008 Mar 26.

PMID:
18363376
6.

bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.

Ayers JT, Dwoskin LP, Deaciuc AG, Grinevich VP, Zhu J, Crooks PA.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3067-71.

PMID:
12372503
7.

Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.

Zaveri N, Jiang F, Olsen C, Polgar W, Toll L.

J Med Chem. 2010 Nov 25;53(22):8187-91. doi: 10.1021/jm1006148. Epub 2010 Oct 27.

8.

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism.

Bourne Y, Radic Z, Aráoz R, Talley TT, Benoit E, Servent D, Taylor P, Molgó J, Marchot P.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6076-81. doi: 10.1073/pnas.0912372107. Epub 2010 Mar 11.

9.

Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.

Ji J, Schrimpf MR, Sippy KB, Bunnelle WH, Li T, Anderson DJ, Faltynek C, Surowy CS, Dyhring T, Ahring PK, Meyer MD.

J Med Chem. 2007 Nov 1;50(22):5493-508. Epub 2007 Oct 11.

PMID:
17929796
10.

Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.

Gao Y, Kuwabara H, Spivak CE, Xiao Y, Kellar K, Ravert HT, Kumar A, Alexander M, Hilton J, Wong DF, Dannals RF, Horti AG.

J Med Chem. 2008 Aug 14;51(15):4751-64. doi: 10.1021/jm800323d. Epub 2008 Jul 8.

PMID:
18605717
11.

Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.

Tasso B, Canu Boido C, Terranova E, Gotti C, Riganti L, Clementi F, Artali R, Bombieri G, Meneghetti F, Sparatore F.

J Med Chem. 2009 Jul 23;52(14):4345-57. doi: 10.1021/jm900225j.

PMID:
19548687
12.

Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.

Zhang HK, Eaton JB, Yu LF, Nys M, Mazzolari A, van Elk R, Smit AB, Alexandrov V, Hanania T, Sabath E, Fedolak A, Brunner D, Lukas RJ, Vistoli G, Ulens C, Kozikowski AP.

J Med Chem. 2012 Sep 27;55(18):8028-37. Epub 2012 Sep 7.

13.

Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.

Dallanoce C, Matera C, Pucci L, Gotti C, Clementi F, Amici MD, Micheli CD.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):829-32. doi: 10.1016/j.bmcl.2011.12.052. Epub 2011 Dec 16.

PMID:
22222032
14.

Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.

Sharples CG, Karig G, Simpson GL, Spencer JA, Wright E, Millar NS, Wonnacott S, Gallagher T.

J Med Chem. 2002 Jul 18;45(15):3235-45.

PMID:
12109907
15.

2. Medicinal chemistry of alpha4beta2 nicotinic cholinergic receptor ligands.

Glennon RA.

Prog Med Chem. 2004;42:55-123. Review. No abstract available.

PMID:
15003719
16.

Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.

Lin NH, Li Y, He Y, Holladay MW, Kuntzweiler T, Anderson DJ, Campbell JE, Arneric SP.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):631-3.

PMID:
11266158
17.

Synthesis and binding studies of epibatidine analogues as ligands for the nicotinic acetylcholine receptors.

Mu L, Drandarov K, Bisson WH, Schibig A, Wirz C, Schubiger PA, Westera G.

Eur J Med Chem. 2006 May;41(5):640-50. Epub 2006 Mar 20.

PMID:
16545497
18.

A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.

Armishaw CJ, Singh N, Medina-Franco JL, Clark RJ, Scott KC, Houghten RA, Jensen AA.

J Biol Chem. 2010 Jan 15;285(3):1809-21. doi: 10.1074/jbc.M109.071183. Epub 2009 Nov 9.

19.

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.

Eibl C, Munoz L, Tomassoli I, Stokes C, Papke RL, Gündisch D.

Bioorg Med Chem. 2013 Dec 1;21(23):7309-29. doi: 10.1016/j.bmc.2013.09.060. Epub 2013 Oct 5.

20.

Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.

Hansen CP, Jensen AA, Christensen JK, Balle T, Liljefors T, Frølund B.

J Med Chem. 2008 Dec 11;51(23):7380-95. doi: 10.1021/jm701625v.

PMID:
18989912
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