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Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog.

Doyon G, Zerbato J, Mellors JW, Sluis-Cremer N.

AIDS. 2013 Jan 14;27(2):F7-F11. doi: 10.1097/QAD.0b013e3283570620.


Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1.

Doyon G, Sobolewski MD, Huber K, McMahon D, Mellors JW, Sluis-Cremer N.

PLoS One. 2014 Jan 29;9(1):e84964. doi: 10.1371/journal.pone.0084964. eCollection 2014.


Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Xing S, Bullen CK, Shroff NS, Shan L, Yang HC, Manucci JL, Bhat S, Zhang H, Margolick JB, Quinn TC, Margolis DM, Siliciano JD, Siliciano RF.

J Virol. 2011 Jun;85(12):6060-4. doi: 10.1128/JVI.02033-10. Epub 2011 Apr 6.


Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.

Ramakrishnan R, Liu H, Rice AP.

AIDS Res Hum Retroviruses. 2015 Jan;31(1):137-41. doi: 10.1089/AID.2013.0288.


Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo.

Zhang H, Chen D, Ringler J, Chen W, Cui QC, Ethier SP, Dou QP, Wu G.

Cancer Res. 2010 May 15;70(10):3996-4004. doi: 10.1158/0008-5472.CAN-09-3752. Epub 2010 Apr 27.


Human immunodeficiency virus type 1 induces lytic cycle replication of Kaposi's-sarcoma-associated herpesvirus: role of Ras/c-Raf/MEK1/2, PI3K/AKT, and NF-κB signaling pathways.

Zhu X, Zhou F, Qin D, Zeng Y, Lv Z, Yao S, Lu C.

J Mol Biol. 2011 Jul 29;410(5):1035-51. doi: 10.1016/j.jmb.2011.03.055.


Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.

Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry JP, Stepan G, Stray KM, Tsai A, Yu H, Spindler J, Kearney M, Spina CA, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T.

PLoS Pathog. 2014 Apr 10;10(4):e1004071. doi: 10.1371/journal.ppat.1004071. eCollection 2014 Apr.


Unique characteristics of histone deacetylase inhibitors in reactivation of latent HIV-1 in Bcl-2-transduced primary resting CD4+ T cells.

Shan L, Xing S, Yang HC, Zhang H, Margolick JB, Siliciano RF.

J Antimicrob Chemother. 2014 Jan;69(1):28-33. doi: 10.1093/jac/dkt338. Epub 2013 Sep 1.


Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation.

Yang HC, Xing S, Shan L, O'Connell K, Dinoso J, Shen A, Zhou Y, Shrum CK, Han Y, Liu JO, Zhang H, Margolick JB, Siliciano RF.

J Clin Invest. 2009 Nov;119(11):3473-86. doi: 10.1172/JCI39199. Epub 2009 Oct 1.


Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells.

Park JK, Jung HY, Park SH, Kang SY, Yi MR, Um HD, Hong SH.

Int J Radiat Oncol Biol Phys. 2008 Apr 1;70(5):1552-60. doi: 10.1016/j.ijrobp.2007.11.069.


Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.

Cell Signal. 2007 Dec;19(12):2444-57. Epub 2007 Aug 3.


Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.

Huber K, Doyon G, Plaks J, Fyne E, Mellors JW, Sluis-Cremer N.

J Biol Chem. 2011 Jun 24;286(25):22211-8. doi: 10.1074/jbc.M110.180224. Epub 2011 Apr 29.


Desmethylanhydroicaritin inhibits NF-kappaB-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway.

Kim JH, Lee G, Cho YL, Kim CK, Han S, Lee H, Choi JS, Choe J, Won MH, Kwon YG, Ha KS, Kim YM.

Eur J Pharmacol. 2009 Jan 14;602(2-3):422-31. doi: 10.1016/j.ejphar.2008.10.062. Epub 2008 Nov 9.


TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer.

Shih MC, Chen JY, Wu YC, Jan YH, Yang BM, Lu PJ, Cheng HC, Huang MS, Yang CJ, Hsiao M, Lai JM.

Oncogene. 2012 May 10;31(19):2389-400. doi: 10.1038/onc.2011.419. Epub 2011 Sep 26.


Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.

Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U.

J Biol Chem. 2010 Sep 3;285(36):27900-10. doi: 10.1074/jbc.M110.117093. Epub 2010 Jul 6.


IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells.

Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Takeyama H.

J Surg Res. 2010 May 1;160(1):90-101. doi: 10.1016/j.jss.2008.08.016. Epub 2008 Sep 13.


Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Reuse S, Calao M, Kabeya K, Guiguen A, Gatot JS, Quivy V, Vanhulle C, Lamine A, Vaira D, Demonte D, Martinelli V, Veithen E, Cherrier T, Avettand V, Poutrel S, Piette J, de Launoit Y, Moutschen M, Burny A, Rouzioux C, De Wit S, Herbein G, Rohr O, Collette Y, Lambotte O, Clumeck N, Van Lint C.

PLoS One. 2009 Jun 30;4(6):e6093. doi: 10.1371/journal.pone.0006093.

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