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Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus.

Fan W, Liang D, Tang Y, Qu B, Cui H, Luo X, Huang X, Chen S, Higgs BW, Jallal B, Yao Y, Harley JB, Shen N.

Arthritis Rheum. 2012 Nov;64(11):3715-25. doi: 10.1002/art.34596.


MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.

Tang Y, Luo X, Cui H, Ni X, Yuan M, Guo Y, Huang X, Zhou H, de Vries N, Tak PP, Chen S, Shen N.

Arthritis Rheum. 2009 Apr;60(4):1065-75. doi: 10.1002/art.24436.


Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression.

Stagakis E, Bertsias G, Verginis P, Nakou M, Hatziapostolou M, Kritikos H, Iliopoulos D, Boumpas DT.

Ann Rheum Dis. 2011 Aug;70(8):1496-506. doi: 10.1136/ard.2010.139857. Epub 2011 May 20.


Decreased microRNA-142-3p/5p expression causes CD4+ T cell activation and B cell hyperstimulation in systemic lupus erythematosus.

Ding S, Liang Y, Zhao M, Liang G, Long H, Zhao S, Wang Y, Yin H, Zhang P, Zhang Q, Lu Q.

Arthritis Rheum. 2012 Sep;64(9):2953-63. doi: 10.1002/art.34505.


Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus.

Zhang Q, Long H, Liao J, Zhao M, Liang G, Wu X, Zhang P, Ding S, Luo S, Lu Q.

J Autoimmun. 2011 Nov;37(3):180-9. doi: 10.1016/j.jaut.2011.09.006. Epub 2011 Oct 19.


MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.

Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X, Li J, Zhou H, Tang Y, Shen N.

J Immunol. 2010 Jun 15;184(12):6773-81. doi: 10.4049/jimmunol.0904060. Epub 2010 May 17.


A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus.

Luo X, Yang W, Ye DQ, Cui H, Zhang Y, Hirankarn N, Qian X, Tang Y, Lau YL, de Vries N, Tak PP, Tsao BP, Shen N.

PLoS Genet. 2011 Jun;7(6):e1002128. doi: 10.1371/journal.pgen.1002128. Epub 2011 Jun 30.


Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity.

Herndon TM, Juang YT, Solomou EE, Rothwell SW, Gourley MF, Tsokos GC.

Clin Immunol. 2002 May;103(2):145-53.


Decreased microRNA(miR)-145 and increased miR-224 expression in T cells from patients with systemic lupus erythematosus involved in lupus immunopathogenesis.

Lu MC, Lai NS, Chen HC, Yu HC, Huang KY, Tung CH, Huang HB, Yu CL.

Clin Exp Immunol. 2013 Jan;171(1):91-9. doi: 10.1111/j.1365-2249.2012.04676.x.


miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation.

Xue F, Li H, Zhang J, Lu J, Xia Y, Xia Q.

Genes Immun. 2013 Mar;14(2):127-31. doi: 10.1038/gene.2012.58. Epub 2013 Jan 10.


MicroRNA-30a promotes B cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn.

Liu Y, Dong J, Mu R, Gao Y, Tan X, Li Y, Li Z, Yang G.

Arthritis Rheum. 2013 Jun;65(6):1603-11. doi: 10.1002/art.37912.


Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.

Solomou EE, Juang YT, Gourley MF, Kammer GM, Tsokos GC.

J Immunol. 2001 Mar 15;166(6):4216-22.


MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1.

Qin H, Zhu X, Liang J, Wu J, Yang Y, Wang S, Shi W, Xu J.

J Dermatol Sci. 2013 Jan;69(1):61-7. doi: 10.1016/j.jdermsci.2012.10.011. Epub 2012 Oct 24.


Reversing interleukin-2 inhibition mediated by anti-double-stranded DNA autoantibody ameliorates glomerulonephritis in MRL-lpr/lpr mice.

Song YC, Tang SJ, Lee TP, Hung WC, Lin SC, Tsai CY, Ng WV, Wu MF, Sun KH.

Arthritis Rheum. 2010 Aug;62(8):2401-11. doi: 10.1002/art.27487.


The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus.

Luo X, Zhang L, Li M, Zhang W, Leng X, Zhang F, Zhao Y, Zeng X.

Clin Exp Rheumatol. 2013 Mar-Apr;31(2):263-71. Epub 2013 Jan 9.


Aberrant T cell expression of Ca2+ influx-regulated miRNAs in patients with systemic lupus erythematosus promotes lupus pathogenesis.

Lu MC, Yu CL, Chen HC, Yu HC, Huang HB, Lai NS.

Rheumatology (Oxford). 2015 Feb;54(2):343-8. doi: 10.1093/rheumatology/keu322. Epub 2014 Aug 28.


An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes.

Curtale G, Citarella F, Carissimi C, Goldoni M, Carucci N, Fulci V, Franceschini D, Meloni F, Barnaba V, Macino G.

Blood. 2010 Jan 14;115(2):265-73. doi: 10.1182/blood-2009-06-225987. Epub 2009 Nov 12.


Transcriptional regulation of interleukin 2 in SLE T cells.

Tenbrock K, Tsokos GC.

Int Rev Immunol. 2004 May-Aug;23(3-4):333-45. Review.


Attempt to correct abnormal signal transduction in T lymphocytes from systemic lupus erythematosus patients.

Fujii Y, Fujii K, Tanaka Y.

Autoimmun Rev. 2006 Feb;5(2):143-4. Epub 2005 Sep 19. Review.

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