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Items: 1 to 20 of 119

1.

Pre-replicative complex assembly with purified proteins.

Mehanna A, Diffley JF.

Methods. 2012 Jun;57(2):222-6. doi: 10.1016/j.ymeth.2012.06.008. Epub 2012 Jun 23.

PMID:
22732456
2.

Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.

Cell. 2009 Nov 13;139(4):719-30. doi: 10.1016/j.cell.2009.10.015. Epub 2009 Nov 5.

3.

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Evrin C, Fernández-Cid A, Zech J, Herrera MC, Riera A, Clarke P, Brill S, Lurz R, Speck C.

Nucleic Acids Res. 2013 Mar 1;41(5):3162-72. doi: 10.1093/nar/gkt043. Epub 2013 Feb 1.

4.

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

Sun J, Evrin C, Samel SA, Fernández-Cid A, Riera A, Kawakami H, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2013 Aug;20(8):944-51. doi: 10.1038/nsmb.2629. Epub 2013 Jul 14.

5.

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C.

Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14.

6.

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication.

Evrin C, Clarke P, Zech J, Lurz R, Sun J, Uhle S, Li H, Stillman B, Speck C.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20240-5. doi: 10.1073/pnas.0911500106. Epub 2009 Nov 12.

7.

Dynamics of pre-replicative complex assembly.

Tsakraklides V, Bell SP.

J Biol Chem. 2010 Mar 26;285(13):9437-43. doi: 10.1074/jbc.M109.072504. Epub 2010 Jan 22.

8.

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.

9.

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

Randell JC, Bowers JL, Rodríguez HK, Bell SP.

Mol Cell. 2006 Jan 6;21(1):29-39.

10.

The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.

Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC.

Mol Cell. 2015 May 7;58(3):483-94. doi: 10.1016/j.molcel.2015.03.017. Epub 2015 Apr 23.

11.

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA.

Samel SA, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C.

Genes Dev. 2014 Aug 1;28(15):1653-66. doi: 10.1101/gad.242404.114.

12.

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase.

Coster G, Frigola J, Beuron F, Morris EP, Diffley JF.

Mol Cell. 2014 Sep 4;55(5):666-77. doi: 10.1016/j.molcel.2014.06.034. Epub 2014 Jul 31.

13.

Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.

Takara TJ, Bell SP.

EMBO J. 2011 Nov 1;30(24):4885-96. doi: 10.1038/emboj.2011.394.

14.

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.

Chen S, de Vries MA, Bell SP.

Genes Dev. 2007 Nov 15;21(22):2897-907.

15.

ATPase-dependent quality control of DNA replication origin licensing.

Frigola J, Remus D, Mehanna A, Diffley JF.

Nature. 2013 Mar 21;495(7441):339-43. doi: 10.1038/nature11920. Epub 2013 Mar 10.

16.

Stepwise assembly of initiation proteins at budding yeast replication origins in vitro.

Seki T, Diffley JF.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14115-20.

17.
18.

Single-molecule studies of origin licensing reveal mechanisms ensuring bidirectional helicase loading.

Ticau S, Friedman LJ, Ivica NA, Gelles J, Bell SP.

Cell. 2015 Apr 23;161(3):513-25. doi: 10.1016/j.cell.2015.03.012. Epub 2015 Apr 16.

19.

Reconstitution of Saccharomyces cerevisiae prereplicative complex assembly in vitro.

Kawasaki Y, Kim HD, Kojima A, Seki T, Sugino A.

Genes Cells. 2006 Jul;11(7):745-56.

20.

Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.

Nguyen VQ, Co C, Irie K, Li JJ.

Curr Biol. 2000 Feb 24;10(4):195-205.

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