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Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

Sobrin L, Ripke S, Yu Y, Fagerness J, Bhangale TR, Tan PL, Souied EH, Buitendijk GH, Merriam JE, Richardson AJ, Raychaudhuri S, Reynolds R, Chin KA, Lee AY, Leveziel N, Zack DJ, Campochiaro P, Smith RT, Barile GR, Hogg RE, Chakravarthy U, Behrens TW, Uitterlinden AG, van Duijn CM, Vingerling JR, Brantley MA Jr, Baird PN, Klaver CC, Allikmets R, Katsanis N, Graham RR, Ioannidis JP, Daly MJ, Seddon JM.

Ophthalmology. 2012 Sep;119(9):1874-85. doi: 10.1016/j.ophtha.2012.03.014. Epub 2012 Jun 15.


ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration.

Sobrin L, Reynolds R, Yu Y, Fagerness J, Leveziel N, Bernstein PS, Souied EH, Daly MJ, Seddon JM.

Am J Ophthalmol. 2011 Feb;151(2):345-52.e3. doi: 10.1016/j.ajo.2010.08.015. Epub 2010 Dec 3.


Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors.

Chen Y, Zeng J, Zhao C, Wang K, Trood E, Buehler J, Weed M, Kasuga D, Bernstein PS, Hughes G, Fu V, Chin J, Lee C, Crocker M, Bedell M, Salasar F, Yang Z, Goldbaum M, Ferreyra H, Freeman WR, Kozak I, Zhang K.

Arch Ophthalmol. 2011 Mar;129(3):344-51. doi: 10.1001/archophthalmol.2011.10.


Inclusion of genotype with fundus phenotype improves accuracy of predicting choroidal neovascularization and geographic atrophy.

Perlee LT, Bansal AT, Gehrs K, Heier JS, Csaky K, Allikmets R, Oeth P, Paladino T, Farkas DH, Rawlings PL, Hageman GS.

Ophthalmology. 2013 Sep;120(9):1880-92. doi: 10.1016/j.ophtha.2013.02.007. Epub 2013 Mar 21.


Genetic analysis of simultaneous geographic atrophy and choroidal neovascularization.

Grob S, Luo J, Hughes G, Lee C, Zhou X, Lee J, Du H, Ferreyra H, Freeman WR, Kozak I, Zhang K.

Eye (Lond). 2012 Aug;26(8):1106-13. doi: 10.1038/eye.2012.107. Epub 2012 Jun 15.


HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration.

Cameron DJ, Yang Z, Gibbs D, Chen H, Kaminoh Y, Jorgensen A, Zeng J, Luo L, Brinton E, Brinton G, Brand JM, Bernstein PS, Zabriskie NA, Tang S, Constantine R, Tong Z, Zhang K.

Cell Cycle. 2007 May 2;6(9):1122-5. Epub 2007 May 16.


Risk characteristics of the combined geographic atrophy and choroidal neovascularisation phenotype in age-related macular degeneration.

Saade C, Ganti B, Marmor M, Freund KB, Smith RT.

Br J Ophthalmol. 2014 Dec;98(12):1729-32. doi: 10.1136/bjophthalmol-2014-305005. Epub 2014 Aug 4.


C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration.

Seddon JM, Gensler G, Rosner B.

Ophthalmology. 2010 Aug;117(8):1560-6. doi: 10.1016/j.ophtha.2009.11.020. Epub 2010 Mar 26.


LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population.

Kondo N, Honda S, Ishibashi K, Tsukahara Y, Negi A.

Am J Ophthalmol. 2007 Oct;144(4):608-12. Epub 2007 Aug 9.


Incidence of choroidal neovascularization in the fellow eye in the comparison of age-related macular degeneration treatments trials.

Maguire MG, Daniel E, Shah AR, Grunwald JE, Hagstrom SA, Avery RL, Huang J, Martin RW, Roth DB, Castellarin AA, Bakri SJ, Fine SL, Martin DF; Comparison of Age-Related Macular Degeneration Treatments Trials (CATT Research Group).

Ophthalmology. 2013 Oct;120(10):2035-41. doi: 10.1016/j.ophtha.2013.03.017. Epub 2013 May 22.


The ARMS2 A69S variant and bilateral advanced age-related macular degeneration.

Schwartz SG, Agarwal A, Kovach JL, Gallins PJ, Cade W, Postel EA, Wang G, Ayala-Haedo J, Spencer KM, Haines JL, Pericak-Vance MA, Scott WK.

Retina. 2012 Sep;32(8):1486-91. doi: 10.1097/IAE.0b013e318240a540.


Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population.

Xu Y, Guan N, Xu J, Yang X, Ma K, Zhou H, Zhang F, Snellingen T, Jiao Y, Liu X, Wang N, Liu N.

Mol Vis. 2008 Jul 28;14:1373-81.


Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population.

Francis PJ, Zhang H, Dewan A, Hoh J, Klein ML.

Mol Vis. 2008 Aug 4;14:1395-400.


Progression of geographic atrophy and genotype in age-related macular degeneration.

Klein ML, Ferris FL 3rd, Francis PJ, Lindblad AS, Chew EY, Hamon SC, Ott J.

Ophthalmology. 2010 Aug;117(8):1554-9, 1559.e1. doi: 10.1016/j.ophtha.2009.12.012. Epub 2010 Apr 9.


Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration.

Andreoli MT, Morrison MA, Kim BJ, Chen L, Adams SM, Miller JW, DeAngelis MM, Kim IK.

Am J Ophthalmol. 2009 Dec;148(6):869-74. doi: 10.1016/j.ajo.2009.07.002. Epub 2009 Oct 1.


Growth of geographic atrophy on fundus autofluorescence and polymorphisms of CFH, CFB, C3, FHR1-3, and ARMS2 in age-related macular degeneration.

Caire J, Recalde S, Velazquez-Villoria A, Garcia-Garcia L, Reiter N, Anter J, Fernandez-Robredo P, Alfredo García-Layana; Spanish Multicenter Group on AMD.

JAMA Ophthalmol. 2014 May;132(5):528-34.


Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study.

Ryu E, Fridley BL, Tosakulwong N, Bailey KR, Edwards AO.

Mol Vis. 2010 Dec 17;16:2811-21.


Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.

Cipriani V, Leung HT, Plagnol V, Bunce C, Khan JC, Shahid H, Moore AT, Harding SP, Bishop PN, Hayward C, Campbell S, Armbrecht AM, Dhillon B, Deary IJ, Campbell H, Dunlop M, Dominiczak AF, Mann SS, Jenkins SA, Webster AR, Bird AC, Lathrop M, Zelenika D, Souied EH, Sahel JA, Léveillard T; French AMD Investigators, Cree AJ, Gibson J, Ennis S, Lotery AJ, Wright AF, Clayton DG, Yates JR.

Hum Mol Genet. 2012 Sep 15;21(18):4138-50. doi: 10.1093/hmg/dds225. Epub 2012 Jun 13.


Association of single nucleotide polymorphisms in CFH, ARMS2 and HTRA1 genes with risk of age-related macular degeneration in Egyptian patients.

Abbas RO, Azzazy HM.

Ophthalmic Genet. 2013 Dec;34(4):209-16. doi: 10.3109/13816810.2012.762934. Epub 2013 Jan 30.

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