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Results: 1 to 20 of 134

1.

In silico and in vitro elucidation of BH3 binding specificity toward Bcl-2.

London N, Gullá S, Keating AE, Schueler-Furman O.

Biochemistry. 2012 Jul 24;51(29):5841-50. doi: 10.1021/bi3003567. Epub 2012 Jul 12.

PMID:
22702834
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL.

Dutta S, Gullá S, Chen TS, Fire E, Grant RA, Keating AE.

J Mol Biol. 2010 May 21;398(5):747-62. doi: 10.1016/j.jmb.2010.03.058. Epub 2010 Apr 2.

PMID:
20363230
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Molecular basis for Bcl-2 homology 3 domain recognition in the Bcl-2 protein family: identification of conserved hot spot interactions.

Moroy G, Martin E, Dejaegere A, Stote RH.

J Biol Chem. 2009 Jun 26;284(26):17499-511. doi: 10.1074/jbc.M805542200. Epub 2009 Mar 17.

PMID:
19293158
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.

Lee EF, Czabotar PE, van Delft MF, Michalak EM, Boyle MJ, Willis SN, Puthalakath H, Bouillet P, Colman PM, Huang DC, Fairlie WD.

J Cell Biol. 2008 Jan 28;180(2):341-55. doi: 10.1083/jcb.200708096. Epub 2008 Jan 21.

PMID:
18209102
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins: comparative molecular dynamics simulations.

Lama D, Sankararamakrishnan R.

Proteins. 2008 Nov 1;73(2):492-514. doi: 10.1002/prot.22075.

PMID:
18452209
[PubMed - indexed for MEDLINE]
6.

BH3 domains other than Bim and Bid can directly activate Bax/Bak.

Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.

J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1.

PMID:
21041309
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Molecular dynamics simulations of pro-apoptotic BH3 peptide helices in aqueous medium: relationship between helix stability and their binding affinities to the anti-apoptotic protein Bcl-X(L).

Lama D, Sankararamakrishnan R.

J Comput Aided Mol Des. 2011 May;25(5):413-26. doi: 10.1007/s10822-011-9428-y. Epub 2011 Apr 27.

PMID:
21523491
[PubMed - indexed for MEDLINE]
8.

Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).

Chen TS, Palacios H, Keating AE.

J Mol Biol. 2013 Jan 9;425(1):171-85. doi: 10.1016/j.jmb.2012.11.009. Epub 2012 Nov 12.

PMID:
23154169
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9.

PMID:
21148306
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.

Boersma MD, Haase HS, Peterson-Kaufman KJ, Lee EF, Clarke OB, Colman PM, Smith BJ, Horne WS, Fairlie WD, Gellman SH.

J Am Chem Soc. 2012 Jan 11;134(1):315-23. doi: 10.1021/ja207148m. Epub 2011 Dec 8.

PMID:
22040025
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members.

Santiveri CM, Sborgi L, de Alba E.

J Mol Recognit. 2012 Dec;25(12):665-73. doi: 10.1002/jmr.2240.

PMID:
23192964
[PubMed - indexed for MEDLINE]
12.

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC.

Mol Cell. 2005 Feb 4;17(3):393-403.

PMID:
15694340
[PubMed - indexed for MEDLINE]
13.

Targeting γ-herpesvirus 68 Bcl-2-mediated down-regulation of autophagy.

Su M, Mei Y, Sanishvili R, Levine B, Colbert CL, Sinha S.

J Biol Chem. 2014 Mar 21;289(12):8029-40. doi: 10.1074/jbc.M113.515361. Epub 2014 Jan 17.

PMID:
24443581
[PubMed - indexed for MEDLINE]
14.

Molecular determinants of Bim(BH3) peptide binding to pro-survival proteins.

Delgado-Soler L, Pinto M, Tanaka-Gil K, Rubio-Martinez J.

J Chem Inf Model. 2012 Aug 27;52(8):2107-18. doi: 10.1021/ci3001666. Epub 2012 Aug 1.

PMID:
22794663
[PubMed - indexed for MEDLINE]
15.

Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1.

Feng W, Huang S, Wu H, Zhang M.

J Mol Biol. 2007 Sep 7;372(1):223-35. Epub 2007 Jun 30.

PMID:
17659302
[PubMed - indexed for MEDLINE]
16.

Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins.

Lee MS, Ha JH, Yoon HS, Lee CK, Chi SW.

Biochem Biophys Res Commun. 2014 Feb 28;445(1):120-5. doi: 10.1016/j.bbrc.2014.01.130. Epub 2014 Feb 1.

PMID:
24491548
[PubMed - indexed for MEDLINE]
17.

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

Liu Q, Leber B, Andrews DW.

Cell Cycle. 2012 Oct 1;11(19):3536-42. doi: 10.4161/cc.21462. Epub 2012 Aug 16.

PMID:
22895112
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.

Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD.

Mol Cell. 2005 Feb 18;17(4):525-35.

PMID:
15721256
[PubMed - indexed for MEDLINE]
19.

A comparison of two strategies for affinity maturation of a BH3 peptide toward pro-survival Bcl-2 proteins.

Zhang S, Long A, Link AJ.

ACS Synth Biol. 2012 Mar 16;1(3):89-98. doi: 10.1021/sb200002m. Epub 2011 Oct 7.

PMID:
23651073
[PubMed - indexed for MEDLINE]
20.

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

Oberstein A, Jeffrey PD, Shi Y.

J Biol Chem. 2007 Apr 27;282(17):13123-32. Epub 2007 Mar 2.

PMID:
17337444
[PubMed - indexed for MEDLINE]
Free Article

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