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Results: 1 to 20 of 135

1.

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

Rubenstein EM, Kreft SG, Greenblatt W, Swanson R, Hochstrasser M.

J Cell Biol. 2012 Jun 11;197(6):761-73. doi: 10.1083/jcb.201203061.

PMID:
22689655
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.

PMID:
23363603
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI).

Kreft SG, Wang L, Hochstrasser M.

J Biol Chem. 2006 Feb 24;281(8):4646-53. Epub 2005 Dec 22.

PMID:
16373356
[PubMed - indexed for MEDLINE]
Free Article
4.

Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase.

Deng M, Hochstrasser M.

Nature. 2006 Oct 19;443(7113):827-31.

PMID:
17051211
[PubMed - indexed for MEDLINE]
5.

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.

Swanson R, Locher M, Hochstrasser M.

Genes Dev. 2001 Oct 15;15(20):2660-74.

PMID:
11641273
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.

Stolz A, Besser S, Hottmann H, Wolf DH.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15271-6. doi: 10.1073/pnas.1304928110. Epub 2013 Aug 29.

PMID:
23988329
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum.

Huang CH, Hsiao HT, Chu YR, Ye Y, Chen X.

J Biol Chem. 2013 Aug 30;288(35):25330-9. doi: 10.1074/jbc.M113.455212. Epub 2013 Jul 18.

PMID:
23867461
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Nakatsukasa K, Brodsky JL, Kamura T.

Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. doi: 10.1091/mbc.E12-12-0907. Epub 2013 Mar 27.

PMID:
23536702
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.

Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N.

J Biol Chem. 2011 May 13;286(19):16929-39. doi: 10.1074/jbc.M110.215871. Epub 2011 Mar 24.

PMID:
21454652
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.

PMID:
23653356
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.

PMID:
20579315
[PubMed - indexed for MEDLINE]
12.

Modularity of the Hrd1 ERAD complex underlies its diverse client range.

Kanehara K, Xie W, Ng DT.

J Cell Biol. 2010 Mar 8;188(5):707-16. doi: 10.1083/jcb.200907055.

PMID:
20212318
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.

Schuberth C, Buchberger A.

Nat Cell Biol. 2005 Oct;7(10):999-1006. Epub 2005 Sep 18.

PMID:
16179952
[PubMed - indexed for MEDLINE]
Free Article
14.

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.

Kikkert M, Doolman R, Dai M, Avner R, Hassink G, van Voorden S, Thanedar S, Roitelman J, Chau V, Wiertz E.

J Biol Chem. 2004 Jan 30;279(5):3525-34. Epub 2003 Oct 30.

PMID:
14593114
[PubMed - indexed for MEDLINE]
Free Article
15.

Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.

Kohlmann S, Schäfer A, Wolf DH.

J Biol Chem. 2008 Jun 13;283(24):16374-83. doi: 10.1074/jbc.M801702200. Epub 2008 Apr 24.

PMID:
18436532
[PubMed - indexed for MEDLINE]
Free Article
16.

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways.

Ravid T, Kreft SG, Hochstrasser M.

EMBO J. 2006 Feb 8;25(3):533-43. Epub 2006 Jan 26.

PMID:
16437165
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

Eisele F, Wolf DH.

FEBS Lett. 2008 Dec 24;582(30):4143-6. doi: 10.1016/j.febslet.2008.11.015. Epub 2008 Nov 27.

PMID:
19041308
[PubMed - indexed for MEDLINE]
Free Article
18.

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.

Plemper RK, Bordallo J, Deak PM, Taxis C, Hitt R, Wolf DH.

J Cell Sci. 1999 Nov;112 ( Pt 22):4123-34.

PMID:
10547371
[PubMed - indexed for MEDLINE]
Free Article
19.

Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner.

Kny M, Standera S, Hartmann-Petersen R, Kloetzel PM, Seeger M.

J Biol Chem. 2011 Feb 18;286(7):5151-6. doi: 10.1074/jbc.M110.134551. Epub 2010 Dec 13.

PMID:
21149444
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

Carvalho P, Goder V, Rapoport TA.

Cell. 2006 Jul 28;126(2):361-73.

PMID:
16873066
[PubMed - indexed for MEDLINE]
Free Article

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