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Results: 1 to 20 of 103

1.

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

Bellucci R, Nguyen HN, Martin A, Heinrichs S, Schinzel AC, Hahn WC, Ritz J.

J Clin Invest. 2012 Jul 2;122(7):2369-83. doi: 10.1172/JCI58457. Epub 2012 Jun 11.

PMID:
22684105
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Janus kinase 2--a novel negative regulator of estrogen receptor α function.

Gupta N, Grebhardt S, Mayer D.

Cell Signal. 2012 Jan;24(1):151-61. doi: 10.1016/j.cellsig.2011.08.016. Epub 2011 Sep 1.

PMID:
21907792
[PubMed - indexed for MEDLINE]
3.

JAK kinases overexpression promotes in vitro cell transformation.

Knoops L, Hornakova T, Royer Y, Constantinescu SN, Renauld JC.

Oncogene. 2008 Mar 6;27(11):1511-9. Epub 2007 Sep 17.

PMID:
17873904
[PubMed - indexed for MEDLINE]
4.

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.

Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders LM, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert BL, Chiosis G, Nimer SD, Bernstein BE, Verstovsek S, Levine RL.

Nature. 2012 Sep 6;489(7414):155-9. doi: 10.1038/nature11303.

PMID:
22820254
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.

Malerich JP, Lam JS, Hart B, Fine RM, Klebansky B, Tanga MJ, D'Andrea A.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7454-7. doi: 10.1016/j.bmcl.2010.10.026. Epub 2010 Oct 13.

PMID:
21106455
[PubMed - indexed for MEDLINE]
6.
7.

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

Li Z, Gakovic M, Ragimbeau J, Eloranta ML, Rönnblom L, Michel F, Pellegrini S.

J Immunol. 2013 Mar 1;190(5):2335-44. doi: 10.4049/jimmunol.1203118. Epub 2013 Jan 28.

PMID:
23359498
[PubMed - indexed for MEDLINE]
Free Article
8.

INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support.

Li J, Favata M, Kelley JA, Caulder E, Thomas B, Wen X, Sparks RB, Arvanitis A, Rogers JD, Combs AP, Vaddi K, Solomon KA, Scherle PA, Newton R, Fridman JS.

Neoplasia. 2010 Jan;12(1):28-38.

PMID:
20072651
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity.

Andrés RM, Hald A, Johansen C, Kragballe K, Iversen L.

Exp Dermatol. 2013 May;22(5):323-8. doi: 10.1111/exd.12128.

PMID:
23614738
[PubMed - indexed for MEDLINE]
10.

Regulation of interferon-inducible proteins by doxorubicin via interferon γ-Janus tyrosine kinase-signal transducer and activator of transcription signaling in tumor cells.

Hussner J, Ameling S, Hammer E, Herzog S, Steil L, Schwebe M, Niessen J, Schroeder HW, Kroemer HK, Ritter CA, Völker U, Bien S.

Mol Pharmacol. 2012 May;81(5):679-88. doi: 10.1124/mol.111.075994. Epub 2012 Feb 9.

PMID:
22323498
[PubMed - indexed for MEDLINE]
Free Article
11.

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

Bacon CM, McVicar DW, Ortaldo JR, Rees RC, O'Shea JJ, Johnston JA.

J Exp Med. 1995 Jan 1;181(1):399-404.

PMID:
7528775
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia.

Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT.

Cancer Discov. 2013 May;3(5):564-77. doi: 10.1158/2159-8290.CD-12-0504. Epub 2013 Mar 7.

PMID:
23471820
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

JAK/STAT/SOCS-signaling pathway and colon and rectal cancer.

Slattery ML, Lundgreen A, Kadlubar SA, Bondurant KL, Wolff RK.

Mol Carcinog. 2013 Feb;52(2):155-66. doi: 10.1002/mc.21841. Epub 2011 Nov 28.

PMID:
22121102
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.

Yu CR, Lin JX, Fink DW, Akira S, Bloom ET, Yamauchi A.

J Immunol. 1996 Jul 1;157(1):126-37.

PMID:
8683106
[PubMed - indexed for MEDLINE]
15.

Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12.

Girart MV, Fuertes MB, Domaica CI, Rossi LE, Zwirner NW.

J Immunol. 2007 Sep 15;179(6):3472-9.

PMID:
17804388
[PubMed - indexed for MEDLINE]
Free Article
16.

Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1.

Melki MT, Saïdi H, Dufour A, Olivo-Marin JC, Gougeon ML.

PLoS Pathog. 2010 Apr 15;6(4):e1000862. doi: 10.1371/journal.ppat.1000862.

PMID:
20419158
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.

Hornakova T, Springuel L, Devreux J, Dusa A, Constantinescu SN, Knoops L, Renauld JC.

Haematologica. 2011 Jun;96(6):845-53. doi: 10.3324/haematol.2010.036350. Epub 2011 Mar 10.

PMID:
21393331
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.

Neilson LM, Zhu J, Xie J, Malabarba MG, Sakamoto K, Wagner KU, Kirken RA, Rui H.

Mol Endocrinol. 2007 Sep;21(9):2218-32. Epub 2007 Jun 5.

PMID:
17550976
[PubMed - indexed for MEDLINE]
19.

Short-term and long-term leptin exposure differentially affect human natural killer cell immune functions.

Wrann CD, Laue T, Hübner L, Kuhlmann S, Jacobs R, Goudeva L, Nave H.

Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E108-16. doi: 10.1152/ajpendo.00057.2011. Epub 2011 Sep 27.

PMID:
21952038
[PubMed - indexed for MEDLINE]
Free Article
20.

UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.

Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D.

J Immunol. 2002 Jan 15;168(2):671-9.

PMID:
11777960
[PubMed - indexed for MEDLINE]
Free Article

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