Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 138

1.

Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse.

Foster JR, Jacobsen M, Kenna G, Schulz-Utermoehl T, Morikawa Y, Salmu J, Wilson ID.

Toxicol Pathol. 2012 Dec;40(8):1106-16. doi: 10.1177/0192623312447542. Epub 2012 Jun 6.

PMID:
22673116
[PubMed - indexed for MEDLINE]
Free Article
2.

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers.

Schulz-Utermoehl T, Sarda S, Foster JR, Jacobsen M, Kenna JG, Morikawa Y, Salmu J, Gross G, Wilson ID.

Xenobiotica. 2012 Jun;42(6):503-17. doi: 10.3109/00498254.2011.640716. Epub 2011 Dec 27.

PMID:
22201515
[PubMed - indexed for MEDLINE]
3.

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD.

J Biol Chem. 2001 Oct 19;276(42):39411-8. Epub 2001 Aug 16.

PMID:
11509573
[PubMed - indexed for MEDLINE]
Free Article
4.

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells.

Ulvestad M, Nordell P, Asplund A, Rehnström M, Jacobsson S, Holmgren G, Davidson L, Brolén G, Edsbagge J, Björquist P, Küppers-Munther B, Andersson TB.

Biochem Pharmacol. 2013 Sep 1;86(5):691-702. doi: 10.1016/j.bcp.2013.06.029. Epub 2013 Jul 12.

PMID:
23856292
[PubMed - indexed for MEDLINE]
5.

Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes.

Lauer B, Tuschl G, Kling M, Mueller SO.

Chem Biol Interact. 2009 Apr 15;179(1):17-24. doi: 10.1016/j.cbi.2008.10.031. Epub 2008 Oct 31.

PMID:
19022234
[PubMed - indexed for MEDLINE]
6.

Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.

Kikuchi R, McCown M, Olson P, Tateno C, Morikawa Y, Katoh Y, Bourdet DL, Monshouwer M, Fretland AJ.

Drug Metab Dispos. 2010 Nov;38(11):1954-61. doi: 10.1124/dmd.109.031732. Epub 2010 Aug 6.

PMID:
20693416
[PubMed - indexed for MEDLINE]
Free Article
7.

Differential disposition of chenodeoxycholic acid versus taurocholic acid in response to acute troglitazone exposure in rat hepatocytes.

Marion TL, Perry CH, St Claire RL 3rd, Yue W, Brouwer KL.

Toxicol Sci. 2011 Apr;120(2):371-80. doi: 10.1093/toxsci/kfr014. Epub 2011 Jan 24.

PMID:
21262925
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Human hepatocytes can repopulate mouse liver: histopathology of the liver in human hepatocyte-transplanted chimeric mice and toxicologic responses to acetaminophen.

Sato Y, Yamada H, Iwasaki K, Tateno C, Yokoi T, Yoshizato K, Horii I.

Toxicol Pathol. 2008 Jun;36(4):581-91. doi: 10.1177/0192623308318212. Epub 2008 May 8.

PMID:
18467679
[PubMed - indexed for MEDLINE]
Free Article
9.

Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver.

Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S.

Drug Metab Dispos. 2012 Feb;40(2):322-8. doi: 10.1124/dmd.111.040923. Epub 2011 Nov 2.

PMID:
22048522
[PubMed - indexed for MEDLINE]
Free Article
10.

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury.

Kakuni M, Morita M, Matsuo K, Katoh Y, Nakajima M, Tateno C, Yokoi T.

Toxicol Lett. 2012 Oct 2;214(1):9-18. doi: 10.1016/j.toxlet.2012.08.001. Epub 2012 Aug 10.

PMID:
22902350
[PubMed - indexed for MEDLINE]
11.

Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice.

Samuelsson K, Pickup K, Sarda S, Foster JR, Randall K, Abrahamsson A, Jacobsen M, Weidolf L, Wilson I.

Xenobiotica. 2014 Jan;44(2):186-95. doi: 10.3109/00498254.2013.879237. Epub 2014 Jan 13.

PMID:
24417752
[PubMed - indexed for MEDLINE]
12.

Endogenous and xenobiotic metabolite profiling of liver extracts from SCID and chimeric humanized mice following repeated oral administration of troglitazone.

Barnes AJ, Baker DR, Hobby K, Ashton S, Michopoulos F, Spagou K, Loftus NJ, Wilson ID.

Xenobiotica. 2014 Jan;44(2):174-85. doi: 10.3109/00498254.2013.867463. Epub 2013 Dec 18.

PMID:
24350779
[PubMed - indexed for MEDLINE]
13.

Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}.

Diao L, Li N, Brayman TG, Hotz KJ, Lai Y.

J Biol Chem. 2010 Oct 8;285(41):31185-92. doi: 10.1074/jbc.M110.107805. Epub 2010 Aug 11.

PMID:
20702406
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes.

Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.

Drug Metab Dispos. 2012 Jan;40(1):76-82. doi: 10.1124/dmd.111.041954. Epub 2011 Oct 7.

PMID:
21984595
[PubMed - indexed for MEDLINE]
Free Article
15.

Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver.

Nishimura M, Yoshitsugu H, Yokoi T, Tateno C, Kataoka M, Horie T, Yoshizato K, Naito S.

Xenobiotica. 2005 Sep;35(9):877-90.

PMID:
16308282
[PubMed - indexed for MEDLINE]
16.

Chimeric mice with humanized liver.

Katoh M, Tateno C, Yoshizato K, Yokoi T.

Toxicology. 2008 Apr 3;246(1):9-17. doi: 10.1016/j.tox.2007.11.012. Epub 2007 Nov 22. Review.

PMID:
18248870
[PubMed - indexed for MEDLINE]
17.

Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2).

Qadri I, Hu LJ, Iwahashi M, Al-Zuabi S, Quattrochi LC, Simon FR.

Toxicol Appl Pharmacol. 2009 Feb 1;234(3):281-92. doi: 10.1016/j.taap.2008.10.005. Epub 2008 Oct 29.

PMID:
19010343
[PubMed - indexed for MEDLINE]
19.

Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice.

Hrycay E, Forrest D, Liu L, Wang R, Tai J, Deo A, Ling V, Bandiera S.

Mol Cell Biochem. 2014 Apr;389(1-2):119-32. doi: 10.1007/s11010-013-1933-y. Epub 2014 Jan 8.

PMID:
24399466
[PubMed - indexed for MEDLINE]
20.

Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile acid stress.

Chen HL, Chen HL, Yuan RH, Wu SH, Chen YH, Chien CS, Chou SP, Wang R, Ling V, Chang MH.

J Cell Mol Med. 2012 Nov;16(11):2679-89. doi: 10.1111/j.1582-4934.2012.01586.x.

PMID:
22564513
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk