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Results: 1 to 20 of 97

1.

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase.

Heasley BH, Pacofsky GJ, Mamai A, Liu H, Nelson K, Coti G, Peel MR, Balkovec JM, Greenlee ML, Liberator P, Meng D, Parker DL, Wilkening RR, Apgar JM, Racine F, Hsu MJ, Giacobbe RA, Kahn JN.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6811-6. doi: 10.1016/j.bmcl.2012.05.031. Epub 2012 May 17.

PMID:
22672801
[PubMed - indexed for MEDLINE]
2.

Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.

Onishi J, Meinz M, Thompson J, Curotto J, Dreikorn S, Rosenbach M, Douglas C, Abruzzo G, Flattery A, Kong L, Cabello A, Vicente F, Pelaez F, Diez MT, Martin I, Bills G, Giacobbe R, Dombrowski A, Schwartz R, Morris S, Harris G, Tsipouras A, Wilson K, Kurtz MB.

Antimicrob Agents Chemother. 2000 Feb;44(2):368-77.

PMID:
10639364
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Synthesis of antifungal glucan synthase inhibitors from enfumafungin.

Zhong YL, Gauthier DR Jr, Shi YJ, McLaughlin M, Chung JY, Dagneau P, Marcune B, Krska SW, Ball RG, Reamer RA, Yasuda N.

J Org Chem. 2012 Apr 6;77(7):3297-310. doi: 10.1021/jo300046v. Epub 2012 Mar 28.

PMID:
22423625
[PubMed - indexed for MEDLINE]
4.

Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1.

Masubuchi K, Okada T, Kohchi M, Sakaitani M, Mizuguchi E, Shirai H, Aoki M, Watanabe T, Kondoh O, Yamazaki T, Satoh Y, Kobayashi K, Inoue T, Horii I, Shimma N.

Bioorg Med Chem Lett. 2001 Feb 12;11(3):395-8.

PMID:
11212119
[PubMed - indexed for MEDLINE]
5.

SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors.

Zhou G, Ting PC, Aslanian R, Cao J, Kim DW, Kuang R, Lee JF, Schwerdt J, Wu H, Herr RJ, Zych AJ, Yang J, Lam S, Wainhaus S, Black TA, McNicholas PM, Xu Y, Walker SS.

Bioorg Med Chem Lett. 2011 May 15;21(10):2890-3. doi: 10.1016/j.bmcl.2011.03.083. Epub 2011 Mar 30.

PMID:
21489787
[PubMed - indexed for MEDLINE]
6.

Synthesis and evaluation of novel macrocyclic antifungal peptides.

Mulder MP, Kruijtzer JA, Breukink EJ, Kemmink J, Pieters RJ, Liskamp RM.

Bioorg Med Chem. 2011 Nov 1;19(21):6505-17. doi: 10.1016/j.bmc.2011.08.034. Epub 2011 Aug 22.

PMID:
21940175
[PubMed - indexed for MEDLINE]
7.

Synthesis, anti-fungal and 1,3-β-D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives.

Ma CM, Abe T, Komiyama T, Wang W, Hattori M, Daneshtalab M.

Bioorg Med Chem. 2010 Oct 1;18(19):7009-14. doi: 10.1016/j.bmc.2010.08.022. Epub 2010 Aug 13.

PMID:
20813534
[PubMed - indexed for MEDLINE]
8.

The optimization of pyridazinone series of glucan synthase inhibitors.

Kuang R, Wu H, Ting PC, Aslanian RG, Cao J, Kim DW, Lee JF, Schwerdt J, Zhou G, Herr RJ, Zych AJ, Yang J, Lam SQ, Jenkins DM, Sakwa SA, Wainhaus S, Black TA, Cacciapuoti A, McNicholas PM, Xu Y, Walker SS.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5268-71. doi: 10.1016/j.bmcl.2012.06.091. Epub 2012 Jul 4.

PMID:
22818082
[PubMed - indexed for MEDLINE]
9.

New β-glucan inhibitors as antifungal drugs.

Hector RF, Bierer DE.

Expert Opin Ther Pat. 2011 Oct;21(10):1597-610. doi: 10.1517/13543776.2011.603899. Epub 2011 Jul 25. Review.

PMID:
21787240
[PubMed - indexed for MEDLINE]
10.

Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase.

Kondoh O, Inagaki Y, Fukuda H, Mizuguchi E, Ohya Y, Arisawa M, Shimma N, Aoki Y, Sakaitani M, Watanabe T.

Biol Pharm Bull. 2005 Nov;28(11):2138-41.

PMID:
16272705
[PubMed - indexed for MEDLINE]
Free Article
11.

Biological activities of synthetic triterpenoid and steroid beta-D-glucopyranosyl-(1-->2)-alpha-D-glucopyranosides.

Takechi M, Kousaka Y, Uno C, Tanaka Y.

Planta Med. 1998 Mar;64(2):179-80.

PMID:
9525112
[PubMed - indexed for MEDLINE]
12.

Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 2.

Masubuchi K, Okada T, Kohchi M, Murata T, Tsukazaki M, Kondoh O, Yamazaki T, Satoh Y, Ono Y, Tsukaguchi T, Kobayashi K, Ono N, Inoue T, Horii I, Shimma N.

Bioorg Med Chem Lett. 2001 May 21;11(10):1273-6.

PMID:
11392535
[PubMed - indexed for MEDLINE]
13.

Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman.

Escalante A, Gattuso M, Pérez P, Zacchino S.

J Nat Prod. 2008 Oct;71(10):1720-5. doi: 10.1021/np070660i. Epub 2008 Sep 25.

PMID:
18816139
[PubMed - indexed for MEDLINE]
14.

Chemical reactivity and antimicrobial activity of N-substituted maleimides.

Salewska N, Boros-Majewska J, Lącka I, Chylińska K, Sabisz M, Milewski S, Milewska MJ.

J Enzyme Inhib Med Chem. 2012 Feb;27(1):117-24. doi: 10.3109/14756366.2011.580455. Epub 2011 May 25.

PMID:
21612375
[PubMed - indexed for MEDLINE]
15.

Sensitive assay for antifungal activity of glucan synthase inhibitors that uses germ tube formation in Candida albicans as an end point.

Brayman TG, Wilks JW.

Antimicrob Agents Chemother. 2003 Oct;47(10):3305-10.

PMID:
14506045
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Arborcandins A, B, C, D, E and F, novel 1,3-beta-glucan synthase inhibitors: production and biological activity.

Ohyama T, Kurihara Y, Ono Y, Ishikawa T, Miyakoshi S, Hamano K, Arai M, Suzuki T, Igari H, Suzuki Y, Inukai M.

J Antibiot (Tokyo). 2000 Oct;53(10):1108-16.

PMID:
11132955
[PubMed - indexed for MEDLINE]
Free Article
17.

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.

Devadas B, Freeman SK, Zupec ME, Lu HF, Nagarajan SR, Kishore NS, Lodge JK, Kuneman DW, McWherter CA, Vinjamoori DV, Getman DP, Gordon JI, Sikorski JA.

J Med Chem. 1997 Aug 1;40(16):2609-25.

PMID:
9258368
[PubMed - indexed for MEDLINE]
18.

Design, synthesis and in vitro evaluation of pyridinium ion based cyclase inhibitors and antifungal agents.

Rose IC, Sharpe BA, Lee RC, Griffin JH, Capobianco JO, Zakula D, Goldman RC.

Bioorg Med Chem. 1996 Jan;4(1):97-103.

PMID:
8689245
[PubMed - indexed for MEDLINE]
19.

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase.

Masubuchi M, Ebiike H, Kawasaki K, Sogabe S, Morikami K, Shiratori Y, Tsujii S, Fujii T, Sakata K, Hayase M, Shindoh H, Aoki Y, Ohtsuka T, Shimma N.

Bioorg Med Chem. 2003 Oct 1;11(20):4463-78.

PMID:
13129583
[PubMed - indexed for MEDLINE]
20.

Characterization and optimization of in vitro assay conditions for (1,3)beta-glucan synthase activity from Aspergillus fumigatus and Candida albicans for enzyme inhibition screening.

Wood RL, Miller TK, Wright A, McCarthy P, Taft CS, Pomponi S, Selitrennikoff CP.

J Antibiot (Tokyo). 1998 Jul;51(7):665-75.

PMID:
9727393
[PubMed - indexed for MEDLINE]
Free Article

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