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Results: 1 to 20 of 82

1.

In vitro metabolism of piperaquine is primarily mediated by CYP3A4.

Lee TM, Huang L, Johnson MK, Lizak P, Kroetz D, Aweeka F, Parikh S.

Xenobiotica. 2012 Nov;42(11):1088-95. doi: 10.3109/00498254.2012.693972. Epub 2012 Jun 6.

PMID:
22671777
[PubMed - indexed for MEDLINE]
2.

Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.

Chang SY, Li W, Traeger SC, Wang B, Cui D, Zhang H, Wen B, Rodrigues AD.

Drug Metab Dispos. 2008 Dec;36(12):2513-22. doi: 10.1124/dmd.108.022970. Epub 2008 Sep 11.

PMID:
18787056
[PubMed - indexed for MEDLINE]
Free Article
3.

Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.

Wang JS, DeVane CL.

Drug Metab Dispos. 2003 Jun;31(6):742-7.

PMID:
12756206
[PubMed - indexed for MEDLINE]
Free Article
4.

Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.

Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, Vachharajani N, Mitroka J.

Drug Metab Dispos. 2005 Apr;33(4):500-7. Epub 2005 Jan 7.

PMID:
15640381
[PubMed - indexed for MEDLINE]
Free Article
5.

Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.

Filppula AM, Laitila J, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2011 May;39(5):904-11. doi: 10.1124/dmd.110.037689. Epub 2011 Feb 2.

PMID:
21289076
[PubMed - indexed for MEDLINE]
Free Article
6.

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.

Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2000 Oct;30(10):955-69.

PMID:
11315104
[PubMed - indexed for MEDLINE]
7.

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

Projean D, Baune B, Farinotti R, Flinois JP, Beaune P, Taburet AM, Ducharme J.

Drug Metab Dispos. 2003 Jun;31(6):748-54.

PMID:
12756207
[PubMed - indexed for MEDLINE]
Free Article
8.

Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response.

Filppula AM, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2013 Jan;41(1):50-9. doi: 10.1124/dmd.112.048017. Epub 2012 Oct 1.

PMID:
23028140
[PubMed - indexed for MEDLINE]
Free Article
9.

Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4.

Renwick AB, Lewis DF, Fulford S, Surry D, Williams B, Worboys PD, Cai X, Wang RW, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2001 Apr;31(4):187-204.

PMID:
11465405
[PubMed - indexed for MEDLINE]
10.

Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.

Karam WG, Goldstein JA, Lasker JM, Ghanayem BI.

Drug Metab Dispos. 1996 Oct;24(10):1081-7.

PMID:
8894508
[PubMed - indexed for MEDLINE]
11.

Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin.

Kajosaari LI, Laitila J, Neuvonen PJ, Backman JT.

Basic Clin Pharmacol Toxicol. 2005 Oct;97(4):249-56.

PMID:
16176562
[PubMed - indexed for MEDLINE]
12.

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.

Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O.

J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66. doi: 10.1016/j.jsbmb.2007.09.025. Epub 2008 Feb 15.

PMID:
18356043
[PubMed - indexed for MEDLINE]
14.

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.

Desta Z, Soukhova N, Morocho AM, Flockhart DA.

J Pharmacol Exp Ther. 2001 Aug;298(2):508-20.

PMID:
11454912
[PubMed - indexed for MEDLINE]
Free Article
15.

Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.

Projean D, Morin PE, Tu TM, Ducharme J.

Xenobiotica. 2003 Aug;33(8):841-54.

PMID:
12936704
[PubMed - indexed for MEDLINE]
16.

In vitro metabolism of BIIB021, an inhibitor of heat shock protein 90, in liver microsomes and hepatocytes of rats, dogs, and humans and recombinant human cytochrome P450 isoforms.

Xu L, Woodward C, Khan S, Prakash C.

Drug Metab Dispos. 2012 Apr;40(4):680-93. doi: 10.1124/dmd.111.043000. Epub 2012 Jan 4.

PMID:
22217465
[PubMed - indexed for MEDLINE]
Free Article
17.

Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes.

Miyazawa M, Shindo M, Shimada T.

Xenobiotica. 2001 Oct;31(10):713-23.

PMID:
11695850
[PubMed - indexed for MEDLINE]
18.

The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4.

Gallagher EP, Kunze KL, Stapleton PL, Eaton DL.

Toxicol Appl Pharmacol. 1996 Dec;141(2):595-606.

PMID:
8975785
[PubMed - indexed for MEDLINE]
19.

The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450.

Ring BJ, Gillespie JS, Binkley SN, Campanale KM, Wrighton SA.

Drug Metab Dispos. 2002 Sep;30(9):957-61.

PMID:
12167559
[PubMed - indexed for MEDLINE]
Free Article
20.

Cytochrome P450 2C8 and CYP3A4/5 are involved in chloroquine metabolism in human liver microsomes.

Kim KA, Park JY, Lee JS, Lim S.

Arch Pharm Res. 2003 Aug;26(8):631-7.

PMID:
12967198
[PubMed - indexed for MEDLINE]

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