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Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution.

Wold LE, Ying Z, Hutchinson KR, Velten M, Gorr MW, Velten C, Youtz DJ, Wang A, Lucchesi PA, Sun Q, Rajagopalan S.

Circ Heart Fail. 2012 Jul 1;5(4):452-61. doi: 10.1161/CIRCHEARTFAILURE.112.966580. Epub 2012 Jun 1.


Early life exposure to air pollution induces adult cardiac dysfunction.

Gorr MW, Velten M, Nelin TD, Youtz DJ, Sun Q, Wold LE.

Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1353-60. doi: 10.1152/ajpheart.00526.2014. Epub 2014 Aug 29.


Morphological and functional changes in cardiac myocytes isolated from mice overexpressing TNF-alpha.

Janczewski AM, Kadokami T, Lemster B, Frye CS, McTiernan CF, Feldman AM.

Am J Physiol Heart Circ Physiol. 2003 Mar;284(3):H960-9. Erratum in: Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):following table of contents. Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H919.


Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.

Ying Z, Yue P, Xu X, Zhong M, Sun Q, Mikolaj M, Wang A, Brook RD, Chen LC, Rajagopalan S.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1540-50. doi: 10.1152/ajpheart.01270.2008. Epub 2009 Mar 13.


Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue.

Xu X, Liu C, Xu Z, Tzan K, Zhong M, Wang A, Lippmann M, Chen LC, Rajagopalan S, Sun Q.

Toxicol Sci. 2011 Nov;124(1):88-98. doi: 10.1093/toxsci/kfr211. Epub 2011 Aug 27.


Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related to Nppa and Npr1 gene knock-out mice.

Tankersley CG, Peng RD, Bedga D, Gabrielson K, Champion HC.

Inhal Toxicol. 2010 Jul;22(8):695-707. doi: 10.3109/08958378.2010.487549.


Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure.

Domenighetti AA, Wang Q, Egger M, Richards SM, Pedrazzini T, Delbridge LM.

Hypertension. 2005 Aug;46(2):426-32. Epub 2005 Jul 5.


Beijing ambient particle exposure accelerates atherosclerosis in ApoE knockout mice.

Chen T, Jia G, Wei Y, Li J.

Toxicol Lett. 2013 Nov 25;223(2):146-53. doi: 10.1016/j.toxlet.2013.09.004. Epub 2013 Sep 14.


Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.

Bye A, Sørhaug S, Ceci M, Høydal MA, Stølen T, Heinrich G, Tjønna AE, Najjar SM, Nilsen OG, Catalucci D, Grimaldi S, Contu R, Steinshamn S, Condorelli G, Smith GL, Ellingsen O, Waldum H, Wisløff U.

Inhal Toxicol. 2008 May;20(7):635-46. doi: 10.1080/08958370701883821 .


Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure.

Haghighi K, Schmidt AG, Hoit BD, Brittsan AG, Yatani A, Lester JW, Zhai J, Kimura Y, Dorn GW 2nd, MacLennan DH, Kranias EG.

J Biol Chem. 2001 Jun 29;276(26):24145-52. Epub 2001 Apr 27.


Cardiac-specific overexpression of metallothionein rescues against cigarette smoking exposure-induced myocardial contractile and mitochondrial damage.

Hu N, Han X, Lane EK, Gao F, Zhang Y, Ren J.

PLoS One. 2013;8(2):e57151. doi: 10.1371/journal.pone.0057151. Epub 2013 Feb 19.


Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.

Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. doi: 10.1152/ajpheart.00452.2009. Epub 2009 Oct 2.


Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

Kučerová D, Baba HA, Bokník P, Fabritz L, Heinick A, Mát'uš M, Müller FU, Neumann J, Schmitz W, Kirchhefer U.

Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2008-17. doi: 10.1152/ajpheart.00457.2011. Epub 2012 Mar 16.


Effects of concentrated ambient particles on normal and hypersecretory airways in rats.

Harkema JR, Keeler G, Wagner J, Morishita M, Timm E, Hotchkiss J, Marsik F, Dvonch T, Kaminski N, Barr E.

Res Rep Health Eff Inst. 2004 Aug;(120):1-68; discussion 69-79.


Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK.

Sun Q, Yue P, Ying Z, Cardounel AJ, Brook RD, Devlin R, Hwang JS, Zweier JL, Chen LC, Rajagopalan S.

Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1760-6. doi: 10.1161/ATVBAHA.108.166967. Epub 2008 Jul 3.


Hemodynamic, autonomic, and vascular effects of exposure to coarse particulate matter air pollution from a rural location.

Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B, Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S.

Environ Health Perspect. 2014 Jun;122(6):624-30. doi: 10.1289/ehp.1306595. Epub 2014 Mar 11.


Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.

Ver Heyen M, Heymans S, Antoons G, Reed T, Periasamy M, Awede B, Lebacq J, Vangheluwe P, Dewerchin M, Collen D, Sipido K, Carmeliet P, Wuytack F.

Circ Res. 2001 Oct 26;89(9):838-46.


Contractile systolic and diastolic dysfunction in renin-induced hypertensive cardiomyopathy.

Flesch M, Schiffer F, Zolk O, Pinto Y, Rosenkranz S, Hirth-Dietrich C, Arnold G, Paul M, Böhm M.

Hypertension. 1997 Sep;30(3 Pt 1):383-91.


Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy.

Kim YK, Suarez J, Hu Y, McDonough PM, Boer C, Dix DJ, Dillmann WH.

Circulation. 2006 Jun 6;113(22):2589-97. Epub 2006 May 30.


Exposure of mice to concentrated ambient particulate matter results in platelet and systemic cytokine activation.

Wilson DW, Aung HH, Lame MW, Plummer L, Pinkerton KE, Ham W, Kleeman M, Norris JW, Tablin F.

Inhal Toxicol. 2010 Mar;22(4):267-76. doi: 10.3109/08958370903278069.

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