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Results: 1 to 20 of 90

1.

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.

Krycer JR, Phan L, Brown AJ.

Biochem J. 2012 Sep 1;446(2):191-201. doi: 10.1042/BJ20120545.

PMID:
22657538
[PubMed - indexed for MEDLINE]
Free Article
2.

Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells.

Prabhu AV, Krycer JR, Brown AJ.

FEBS Lett. 2013 Apr 2;587(7):983-8. doi: 10.1016/j.febslet.2013.02.040. Epub 2013 Feb 27.

PMID:
23454642
[PubMed - indexed for MEDLINE]
Free Article
3.

Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis?

Krycer JR, Brown AJ.

PLoS One. 2013;8(1):e54007. doi: 10.1371/journal.pone.0054007. Epub 2013 Jan 8.

PMID:
23320115
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.

Ettinger SL, Sobel R, Whitmore TG, Akbari M, Bradley DR, Gleave ME, Nelson CC.

Cancer Res. 2004 Mar 15;64(6):2212-21.

PMID:
15026365
[PubMed - indexed for MEDLINE]
Free Article
5.

Taurine is a liver X receptor-α ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis.

Hoang MH, Jia Y, Jun HJ, Lee JH, Hwang KY, Choi DW, Um SJ, Lee BY, You SG, Lee SJ.

Mol Nutr Food Res. 2012 Jun;56(6):900-11. doi: 10.1002/mnfr.201100611.

PMID:
22707265
[PubMed - indexed for MEDLINE]
6.

Cholesterol homeostasis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3.

Krycer JR, Kristiana I, Brown AJ.

PLoS One. 2009 Dec 30;4(12):e8496. doi: 10.1371/journal.pone.0008496.

PMID:
20041144
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway.

Yang CM, Lu YL, Chen HY, Hu ML.

J Nutr Biochem. 2012 Sep;23(9):1155-62. doi: 10.1016/j.jnutbio.2011.06.009. Epub 2011 Dec 1.

PMID:
22137263
[PubMed - indexed for MEDLINE]
8.

Akt acutely activates the cholesterogenic transcription factor SREBP-2.

Luu W, Sharpe LJ, Stevenson J, Brown AJ.

Biochim Biophys Acta. 2012 Feb;1823(2):458-64. doi: 10.1016/j.bbamcr.2011.09.017. Epub 2011 Oct 8.

PMID:
22005015
[PubMed - indexed for MEDLINE]
Free Article
9.

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Rodríguez-Acebes S, de la Cueva P, Fernández-Hernando C, Ferruelo AJ, Lasunción MA, Rawson RB, Martínez-Botas J, Gómez-Coronado D.

Biochem J. 2009 May 13;420(2):305-15. doi: 10.1042/BJ20081909.

PMID:
19260826
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Cross-talk between the androgen receptor and the liver X receptor: implications for cholesterol homeostasis.

Krycer JR, Brown AJ.

J Biol Chem. 2011 Jun 10;286(23):20637-47. doi: 10.1074/jbc.M111.227082. Epub 2011 Apr 13.

PMID:
21489984
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Overexpression of A-kinase anchoring protein 12A activates sterol regulatory element binding protein-2 and enhances cholesterol efflux in hepatic cells.

Choi MC, Lee YU, Kim SH, Lee JH, Park JH, Streb JW, Oh DY, Im SA, Kim TY, Jong HS, Bang YJ.

Int J Biochem Cell Biol. 2008;40(11):2534-43. doi: 10.1016/j.biocel.2008.04.020. Epub 2008 May 20.

PMID:
18579430
[PubMed - indexed for MEDLINE]
12.

Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development.

Bobard A, Hainault I, Ferré P, Foufelle F, Bossard P.

J Biol Chem. 2005 Jan 7;280(1):199-206. Epub 2004 Oct 27.

PMID:
15509573
[PubMed - indexed for MEDLINE]
Free Article
13.

Rapamycin down-regulates LDL-receptor expression independently of SREBP-2.

Sharpe LJ, Brown AJ.

Biochem Biophys Res Commun. 2008 Sep 5;373(4):670-4. doi: 10.1016/j.bbrc.2008.06.108. Epub 2008 Jul 9.

PMID:
18602894
[PubMed - indexed for MEDLINE]
14.

Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products.

Yeh M, Cole AL, Choi J, Liu Y, Tulchinsky D, Qiao JH, Fishbein MC, Dooley AN, Hovnanian T, Mouilleseaux K, Vora DK, Yang WP, Gargalovic P, Kirchgessner T, Shyy JY, Berliner JA.

Circ Res. 2004 Oct 15;95(8):780-8. Epub 2004 Sep 23.

PMID:
15388640
[PubMed - indexed for MEDLINE]
Free Article
15.

MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells.

Li X, Chen YT, Josson S, Mukhopadhyay NK, Kim J, Freeman MR, Huang WC.

PLoS One. 2013 Aug 9;8(8):e70987. doi: 10.1371/journal.pone.0070987. eCollection 2013.

PMID:
23951060
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis.

Du X, Kristiana I, Wong J, Brown AJ.

Mol Biol Cell. 2006 Jun;17(6):2735-45. Epub 2006 Mar 29.

PMID:
16571675
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Reduced VLDL clearance in Apoe(-/-)Npc1(-/-) mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels.

Ishibashi M, Masson D, Westerterp M, Wang N, Sayers S, Li R, Welch CL, Tall AR.

J Lipid Res. 2010 Sep;51(9):2655-63. doi: 10.1194/jlr.M006163. Epub 2010 Jun 18.

PMID:
20562239
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer.

Campbell SE, Rudder B, Phillips RB, Whaley SG, Stimmel JB, Leesnitzer LM, Lightner J, Dessus-Babus S, Duffourc M, Stone WL, Menter DG, Newman RA, Yang P, Aggarwal BB, Krishnan K.

Free Radic Biol Med. 2011 May 15;50(10):1344-54. doi: 10.1016/j.freeradbiomed.2011.02.007. Epub 2011 Feb 16.

PMID:
21335085
[PubMed - indexed for MEDLINE]
19.

The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP.

Janowski BA.

Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12675-80. Epub 2002 Sep 19.

PMID:
12242342
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

Abildayeva K, Jansen PJ, Hirsch-Reinshagen V, Bloks VW, Bakker AH, Ramaekers FC, de Vente J, Groen AK, Wellington CL, Kuipers F, Mulder M.

J Biol Chem. 2006 May 5;281(18):12799-808. Epub 2006 Mar 8.

PMID:
16524875
[PubMed - indexed for MEDLINE]
Free Article

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