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Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling.

Campbell PE, Isayev O, Ali SA, Roth WW, Huang MB, Powell MD, Leszczynski J, Bond VC.

J Mol Model. 2012 Oct;18(10):4603-13. doi: 10.1007/s00894-012-1452-x. Epub 2012 May 30.


Genetic characterization of HIV type 1 Nef-induced vesicle secretion.

Ali SA, Huang MB, Campbell PE, Roth WW, Campbell T, Khan M, Newman G, Villinger F, Powell MD, Bond VC.

AIDS Res Hum Retroviruses. 2010 Feb;26(2):173-92. doi: 10.1089/aid.2009.0068.


Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.

Shelton MN, Huang MB, Ali SA, Powell MD, Bond VC.

J Virol. 2012 Jan;86(1):406-19. doi: 10.1128/JVI.05720-11. Epub 2011 Oct 19.


Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.

Meuwissen PJ, Stolp B, Iannucci V, Vermeire J, Naessens E, Saksela K, Geyer M, Vanham G, Arien KK, Fackler OT, Verhasselt B.

Retrovirology. 2012 Apr 27;9:34. doi: 10.1186/1742-4690-9-34.


An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I.

Dikeakos JD, Thomas L, Kwon G, Elferich J, Shinde U, Thomas G.

Mol Biol Cell. 2012 Jun;23(11):2184-97. doi: 10.1091/mbc.E11-11-0928. Epub 2012 Apr 11.


Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.

Kawano Y, Tanaka Y, Misawa N, Tanaka R, Kira JI, Kimura T, Fukushi M, Sano K, Goto T, Nakai M, Kobayashi T, Yamamoto N, Koyanagi Y.

J Virol. 1997 Nov;71(11):8456-66.


Identification of a novel binding site between HIV type 1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation.

Jin YJ, Cai CY, Mezei M, Ohlmeyer M, Sanchez R, Burakoff SJ.

AIDS Res Hum Retroviruses. 2013 Apr;29(4):725-31. doi: 10.1089/AID.2012.0286. Epub 2012 Dec 31.


Phenotype and envelope gene diversity of nef-deleted HIV-1 isolated from long-term survivors infected from a single source.

Gray L, Churchill MJ, Sterjovski J, Witlox K, Learmont JC, Sullivan JS, Wesselingh SL, Gabuzda D, Cunningham AL, McPhee DA, Gorry PR.

Virol J. 2007 Jul 16;4:75.


Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly.

Horenkamp FA, Breuer S, Schulte A, Lülf S, Weyand M, Saksela K, Geyer M.

Traffic. 2011 Jul;12(7):867-77. doi: 10.1111/j.1600-0854.2011.01205.x. Epub 2011 May 5.


HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

Mangino G, Percario ZA, Fiorucci G, Vaccari G, Acconcia F, Chiarabelli C, Leone S, Noto A, Horenkamp FA, Manrique S, Romeo G, Polticelli F, Geyer M, Affabris E.

PLoS One. 2011;6(8):e22982. doi: 10.1371/journal.pone.0022982. Epub 2011 Aug 23.


Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix.

Kuo LS, Baugh LL, Denial SJ, Watkins RL, Liu M, Garcia JV, Foster JL.

Retrovirology. 2012 May 31;9:47. doi: 10.1186/1742-4690-9-47.


Defective nef alleles in a cohort of hemophiliacs with progressing and nonprogressing HIV-1 infection.

Brambilla A, Turchetto L, Gatti A, Bovolenta C, Veglia F, Santagostino E, Gringeri A, Clementi M, Poli G, Bagnarelli P, Vicenzi E.

Virology. 1999 Jul 5;259(2):349-68.


SIV/HIV Nef recombinant virus (SHIVnef) produces simian AIDS in rhesus macaques.

Mandell CP, Reyes RA, Cho K, Sawai ET, Fang AL, Schmidt KA, Luciw PA.

Virology. 1999 Dec 20;265(2):235-51.


Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.

Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J.

Cell. 1996 Jun 14;85(6):931-42.


Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.

Jung J, Byeon IJ, Ahn J, Gronenborn AM.

Proteins. 2011 May;79(5):1609-22. doi: 10.1002/prot.22986. Epub 2011 Mar 1.

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