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Results: 1 to 20 of 127

1.

The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir in healthy volunteers.

Garg V, Chandorkar G, Yang Y, Adda N, McNair L, Alves K, Smith F, van Heeswijk RP.

Br J Clin Pharmacol. 2013 Feb;75(2):431-9. doi: 10.1111/j.1365-2125.2012.04345.x.

PMID:
22642697
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Effects of ketoconazole and rifampicin on the pharmacokinetics of gemigliptin, a dipeptidyl peptidase-IV inhibitor: a crossover drug-drug interaction study in healthy male Korean volunteers.

Noh YH, Lim HS, Jin SJ, Kim MJ, Kim YH, Sung HR, Choi HY, Bae KS.

Clin Ther. 2012 May;34(5):1182-94. doi: 10.1016/j.clinthera.2012.04.001. Epub 2012 Apr 24.

PMID:
22534255
[PubMed - indexed for MEDLINE]
3.

Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects.

Shoaf SE, Bricmont P, Mallikaarjun S.

Br J Clin Pharmacol. 2012 Apr;73(4):579-87. doi: 10.1111/j.1365-2125.2011.04114.x.

PMID:
21988334
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron, a β3-adrenoceptor agonist.

Lee J, Moy S, Meijer J, Krauwinkel W, Sawamoto T, Kerbusch V, Kowalski D, Roy M, Marion A, Takusagawa S, van Gelderen M, Keirns J.

Clin Drug Investig. 2013 Jun;33(6):429-40. doi: 10.1007/s40261-013-0084-y.

PMID:
23625188
[PubMed - indexed for MEDLINE]
5.

Effect of telaprevir on the pharmacokinetics of midazolam and digoxin.

Garg V, Chandorkar G, Farmer HF, Smith F, Alves K, van Heeswijk RP.

J Clin Pharmacol. 2012 Oct;52(10):1566-73. Epub 2011 Dec 12.

PMID:
22162542
[PubMed - indexed for MEDLINE]
6.

The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study.

Shin KH, Kim BH, Kim TE, Kim JW, Yi S, Yoon SH, Cho JY, Shin SG, Jang IJ, Yu KS.

Clin Ther. 2009 Dec;31(12):3009-20. doi: 10.1016/j.clinthera.2009.12.012.

PMID:
20110038
[PubMed - indexed for MEDLINE]
7.

Ascending single-dose study of the safety profile, tolerability, and pharmacokinetics of bosutinib coadministered with ketoconazole to healthy adult subjects.

Abbas R, Leister C, El Gaaloul M, Chalon S, Sonnichsen D.

Clin Ther. 2012 Sep;34(9):2011-9.e1. doi: 10.1016/j.clinthera.2012.07.006. Epub 2012 Aug 9.

PMID:
22884766
[PubMed - indexed for MEDLINE]
8.

Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers.

Mahatthanatrakul W, Sriwiriyajan S, Ridtitid W, Boonleang J, Wongnawa M, Rujimamahasan N, Pipatrattanaseree W.

J Clin Pharm Ther. 2012 Apr;37(2):221-5. doi: 10.1111/j.1365-2710.2011.01271.x. Epub 2011 Apr 26.

PMID:
21518375
[PubMed - indexed for MEDLINE]
9.

Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin.

Troost J, Tatami S, Tsuda Y, Mattheus M, Mehlburger L, Wein M, Michel MC.

Br J Clin Pharmacol. 2011 Aug;72(2):247-56. doi: 10.1111/j.1365-2125.2011.03988.x.

PMID:
21496064
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients.

Grub S, Bryson H, Goggin T, Lüdin E, Jorga K.

Eur J Clin Pharmacol. 2001 May;57(2):115-21.

PMID:
11417442
[PubMed - indexed for MEDLINE]
11.

Phase I evaluation of the effects of ketoconazole and rifampicin on cediranib pharmacokinetics in patients with solid tumours.

Lassen U, Miller WH, Hotte S, Evans TR, Kollmansberger C, Adamson D, Nielsen DL, Spicer J, Chen E, Meyer T, Brown K, Rafi R, Sawyer MB.

Cancer Chemother Pharmacol. 2013 Feb;71(2):543-9. doi: 10.1007/s00280-012-2038-0. Epub 2012 Nov 30.

PMID:
23196640
[PubMed - indexed for MEDLINE]
12.

Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs.

Zhou X, Gao ZW, Meng J, Chen XY, Zhong DF.

Acta Pharmacol Sin. 2013 Nov;34(11):1420-6. doi: 10.1038/aps.2013.76. Epub 2013 Sep 23.

PMID:
24056704
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatin.

Lee JE, van Heeswijk R, Alves K, Smith F, Garg V.

Antimicrob Agents Chemother. 2011 Oct;55(10):4569-74. doi: 10.1128/AAC.00653-11. Epub 2011 Aug 8.

PMID:
21825288
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The effect of multiple doses of rifampin and ketoconazole on the single-dose pharmacokinetics of ridaforolimus.

Stroh M, Palcza J, McCrea J, Marsilio S, Breidinger S, Panebianco D, Johnson-Levonas A, Kraft WK, Orford K, Murphy G, Agrawal N, Trucksis M, Wagner JA, Iwamoto M.

Cancer Chemother Pharmacol. 2012 May;69(5):1247-53. doi: 10.1007/s00280-011-1819-1.

PMID:
22290273
[PubMed - indexed for MEDLINE]
15.

Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers.

Pithavala YK, Tong W, Mount J, Rahavendran SV, Garrett M, Hee B, Selaru P, Sarapa N, Klamerus KJ.

Invest New Drugs. 2012 Feb;30(1):273-81. doi: 10.1007/s10637-010-9511-6. Epub 2010 Aug 26.

PMID:
20740300
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Evaluation of the effect of food and ketoconazole on the pharmacokinetics of the smoothened inhibitor PF-04449913 in healthy volunteers.

Shaik MN, LaBadie RR, Rudin D, Levin WJ.

Cancer Chemother Pharmacol. 2014 Aug;74(2):411-8. doi: 10.1007/s00280-014-2502-0. Epub 2014 Jun 19.

PMID:
24944041
[PubMed - indexed for MEDLINE]
17.

Phase I study of cabazitaxel plus cisplatin in patients with advanced solid tumors: study to evaluate the impact of cytochrome P450 3A inhibitors (aprepitant, ketoconazole) or inducers (rifampin) on the pharmacokinetics of cabazitaxel.

Sarantopoulos J, Mita AC, Wade JL, Morris JC, Rixe O, Mita MM, Dedieu JF, Wack C, Kassalow L, Lockhart AC.

Cancer Chemother Pharmacol. 2014 Dec;74(6):1113-24. doi: 10.1007/s00280-014-2572-z. Epub 2014 Oct 12.

PMID:
25307552
[PubMed - indexed for MEDLINE]
18.

Ketoconazole and rifampin significantly affect the pharmacokinetics, but not the safety or QTc interval, of casopitant, a neurokinin-1 receptor antagonist.

Johnson BM, Adams LM, Zhang K, Gainer SD, Kirby LC, Blum RA, Apseloff G, Morrison RA, Schutz RA, Lebowitz PF.

J Clin Pharmacol. 2010 Aug;50(8):951-9. doi: 10.1177/0091270009353761. Epub 2010 Feb 2.

PMID:
20124517
[PubMed - indexed for MEDLINE]
19.

Effects of rifampin and ketoconazole on the pharmacokinetics of nilotinib in healthy participants.

Tanaka C, Yin OQ, Smith T, Sethuraman V, Grouss K, Galitz L, Harrell R, Schran H.

J Clin Pharmacol. 2011 Jan;51(1):75-83. doi: 10.1177/0091270010367428. Epub 2010 Aug 11.

PMID:
20702754
[PubMed - indexed for MEDLINE]
20.

Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects.

Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D.

Br J Clin Pharmacol. 2011 Apr;71(4):522-7. doi: 10.1111/j.1365-2125.2010.03845.x.

PMID:
21395644
[PubMed - indexed for MEDLINE]
Free PMC Article

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