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22641095,19226377,18666257,26336926,23996730,26201023,22902550,17681180,25967348,25548482,32191680,30917489,19676126,18422963,24845607,24117897,19386026,19446916,28844958,15464239,16174657,22411067,26431211,26203862,29890136,23299577,23832324,27321932,22455888,31857195,35292349,17244458,30261289,24294355,15044174,17868334,24395441,16706830,21488066,28468951,10580504,18571789,24136786,12032825,21985374,18534710,26058518,21321532,21537547,26723251,16950832,28323124,26506376,25888330,23044079,25499814,30914267,28192190,25810038,25443620,35164140,33857628,19764881,27069868,23993977,26394162,23832448,24329600,31521175,24795036,23792031,28286271,29229391,24702805,17464987,27119348,22633099,29158819,27421788,24378437,25790295,25053716,26403427,23850676,28578014,20509914,29963902,30744124,27180087,23092318,33098092,30194936,28322783,12971963,31189885,26698665,29126873,22796156,25217205,21425308,20848203,26464652,22297845,28877220,24865256,20712406,30484323,30537674,29330836,22290395,29244873,30576769,22642111,25849376,22744176,27318147,20962016,22152378,19119140,30539788,21983898,23906870,32438122,29128353,30778201,24480733,14734794,34369032,31756344,25501551,28092182,32365632,32023549,27245430,32376267,25524583,28303974,23508103,30473026,29290620,33894425,30538805,34757046,23461363,28112179,21492876,21814826,36610223,27773935,29107687,26768586,22039050,22118966,21616139,27628106,29705240,23331460,21745592,24941342,19168439,28108233,22699396,32717288,32081971,22561705,32220030,27729272,31607566,29802399,30588181,35672379,25451254,27967209,28073164,30876690,27723801,20347818,29715085,26883167,22076166,19577569,25815500,27135827,22687340,21567402,25372401,25672270,26576483,20061561,34656650,32795504,17036395,23117377,10029293,29140985,36775348,28711489,29274380,19355920,28632732,11865197,31428222,26222667,22380754,20557969,14568258,23875831,24930012,32238704,27282405,25890053,28421320,28132890,21965735,21354232,28676836,26818807,27567443,28100771,24845561,29355950,30400205,22020565,31341404,26319415,24749340,21506908,27626309,25256142,24325816,29964317,28659437,33545428,20979658,34098145,26070409,30083132,28600126,35986536,35681549,24632974,33571553,31171766,23898068,26494227,24550542,29981428,29975946,24223793,18504439,25790822,36210705,31393852,21040401,23069937,25623824,27764896,20157513,26703444,30160786,29792946,29266399,32699233,19892704,18490896,19696221,33303970,28218651,20111892,26394163,30401637,16251354,31950520,24618848,35547757,24180261,27530145,21047172,9361818,30125542,23441159,26523473,9218130,30481403,30298839,36038328,26555271,29077881,24184494,16357615,31510077,23237310,24085465,24322749,19450891,21088479,22100252,27911443,29560693,24395385,24766279,30973211,22253905,26473743,20566667,31422074,23849861,25400762,32084378,33212187,36150682,31086120,35181322,24135202,27610009,25012499,20961644,23935128,16677103,29509254,17272725,34505423,28467181,35739253,33790913,35278882,27125489,27049024,33251225,23938287,32317079,20607654,29574534,27302565,21747166,31861914,35726536,29214510,23499302,19358839,18611248,30819907,32259482,15998704,26116535,31857389,27893783,28073183,21264241,31795496,24211274,32354858,35221291,37096379,23155240,12891546,36209205,27220460,23558563,12406439,29299759,31051106,12971256,28978535,36371329,31850710,26600128,34411785,30559308,29050312,23448364,35449483,26064924,22641094,32820144,31215672,25347188,23417738,36163170,22561871,23140643,32903542,31380833,27189521,24115079,31686782,33495844,28415887,27712037,27605885,36631036,35485140,21350309,29462661,27974211,23924762,29855491,15970563,11106802,14708419,9498280,22588161,36592660,17540768,7645429,23538210,26023714,29352207,31746151,18511487,24162160,26637970,28273461,33953700,27881164,32796650,24254390,24106341,33005011,18334675,36072934,29128616,35696550,9111207,23875779,22583519,27811061,23918930,34119957,20689155,23142622,21737566,36775485,33664289,33726979,29719629,26406121,28110190,31810868,29041825,28298638,28740219,28913408,17729114,24008361,30048033,35927268,29453337,36265795,32477107,26133108,29346757,35217669,31953228,34821107,26201793,35612429,19527485,34136664,20458758,32970940,25797622,25556747,32438524,31598806,31202267,26617882,24165399,25821638,28586195,31983631,33662427,34117031,35839302,23448275,32638492,1782374,16463673,23704521,34478580,20716932,27701715,24005285,31008094,20618457,16471264,19273598,29707653,23744565,24336818,30099089,33517537,29558460,11819822,25620266,32274384,24179615,25713801,31945016,25364750,27063723,29358667,35367283,21645964,30135418,11439219,22751196,27639263,34049413,32922061,35102341,35212991,15220676,11311572,33353156,33504761,35971677,32382414,34660604,32513909,29844359,16499209,16202648,33961941,37156795,29992419,20565814,33922660,31575671,32429320,28743981,36354784,22649663,28377639,24452327,35454121,16490391,24327572,22051552,32342535,24443149,31881182,27321056,26324414,33526291,27664064,34493776,30823907[uid]

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p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice.

Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi T. Tomita K, et al. J Hepatol. 2012 Oct;57(4):837-43. doi: 10.1016/j.jhep.2012.05.013. Epub 2012 May 26. J Hepatol. 2012. PMID: 22641095

Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression.

Farrell GC, Larter CZ, Hou JY, Zhang RH, Yeh MM, Williams J, dela Pena A, Francisco R, Osvath SR, Brooling J, Teoh N, Sedger LM. Farrell GC, et al. J Gastroenterol Hepatol. 2009 Mar;24(3):443-52. doi: 10.1111/j.1440-1746.2009.05785.x. Epub 2008 Feb 15. J Gastroenterol Hepatol. 2009. PMID: 19226377

Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice.

Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, Mizutani A, Yokoyama H, Irie R, Sumimoto H, Takayanagi A, Miyashita K, Akao M, Tabata M, Tamiya G, Ohkura T, Hibi T. Tomita K, et al. Hepatology. 2008 Aug;48(2):458-73. doi: 10.1002/hep.22365. Hepatology. 2008. PMID: 18666257

The p66Shc protein controls redox signaling and oxidation-dependent DNA damage in human liver cells.

Perrini S, Tortosa F, Natalicchio A, Pacelli C, Cignarelli A, Palmieri VO, Caccioppoli C, De Stefano F, Porro S, Leonardini A, Ficarella R, De Fazio M, Cocco T, Puglisi F, Laviola L, Palasciano G, Giorgino F. Perrini S, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Nov 15;309(10):G826-40. doi: 10.1152/ajpgi.00041.2015. Epub 2015 Sep 3. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26336926 Free article.

Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice.

Yang L, Roh YS, Song J, Zhang B, Liu C, Loomba R, Seki E. Yang L, et al. Hepatology. 2014 Feb;59(2):483-95. doi: 10.1002/hep.26698. Epub 2013 Dec 18. Hepatology. 2014. PMID: 23996730 Free PMC article.

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis.

Afonso MB, Rodrigues PM, Carvalho T, Caridade M, Borralho P, Cortez-Pinto H, Castro RE, Rodrigues CM. Afonso MB, et al. Clin Sci (Lond). 2015 Oct 1;129(8):721-39. doi: 10.1042/CS20140732. Epub 2015 Jun 15. Clin Sci (Lond). 2015. PMID: 26201023

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.

Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CM. Castro RE, et al. J Hepatol. 2013 Jan;58(1):119-25. doi: 10.1016/j.jhep.2012.08.008. Epub 2012 Aug 15. J Hepatol. 2013. PMID: 22902550

Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.

Nocito A, Dahm F, Jochum W, Jang JH, Georgiev P, Bader M, Renner EL, Clavien PA. Nocito A, et al. Gastroenterology. 2007 Aug;133(2):608-18. doi: 10.1053/j.gastro.2007.05.019. Epub 2007 May 21. Gastroenterology. 2007. PMID: 17681180

Epigallocatechin gallate attenuated non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet.

Ding Y, Sun X, Chen Y, Deng Y, Qian K. Ding Y, et al. Eur J Pharmacol. 2015 Aug 15;761:405-12. doi: 10.1016/j.ejphar.2015.05.005. Epub 2015 May 9. Eur J Pharmacol. 2015. PMID: 25967348

Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.

Simon Y, Kessler SM, Gemperlein K, Bohle RM, Müller R, Haybaeck J, Kiemer AK. Simon Y, et al. World J Gastroenterol. 2014 Dec 21;20(47):17839-50. doi: 10.3748/wjg.v20.i47.17839. World J Gastroenterol. 2014. PMID: 25548482 Free PMC article.

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