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Results: 1 to 20 of 206

1.

Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.

Das HK, Tchedre K, Mueller B.

J Neurochem. 2012 Aug;122(3):487-500. doi: 10.1111/j.1471-4159.2012.07794.x. Epub 2012 Jun 22.

PMID:
22607268
[PubMed - indexed for MEDLINE]
2.

Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism.

Lee S, Das HK.

Brain Res. 2008 May 1;1207:19-31. doi: 10.1016/j.brainres.2008.02.016. Epub 2008 Mar 28.

PMID:
18374905
[PubMed - indexed for MEDLINE]
3.

Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis.

Rahman M, Zhang Z, Mody AA, Su DM, Das HK.

Brain Res. 2012 Apr 11;1448:117-28. doi: 10.1016/j.brainres.2012.01.066. Epub 2012 Feb 3.

PMID:
22353755
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.

Popescu BO, Cedazo-Minguez A, Benedikz E, Nishimura T, Winblad B, Ankarcrona M, Cowburn RF.

J Biol Chem. 2004 Feb 20;279(8):6455-64. Epub 2003 Nov 18.

PMID:
14625299
[PubMed - indexed for MEDLINE]
Free Article
5.

Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity.

Lee S, Das HK.

Front Biosci (Elite Ed). 2010 Jan 1;2:22-35.

PMID:
20036849
[PubMed - indexed for MEDLINE]
6.

Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.

Rivabene R, Visentin S, Piscopo P, De Nuccio C, Crestini A, Svetoni F, Rosa P, Confaloni A.

Exp Biol Med (Maywood). 2014 Feb;239(2):213-24. doi: 10.1177/1535370213514317. Epub 2013 Dec 20.

PMID:
24363250
[PubMed - indexed for MEDLINE]
7.

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I.

Cell. 2006 Sep 8;126(5):981-93.

PMID:
16959576
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.

Nelson O, Supnet C, Liu H, Bezprozvanny I.

J Alzheimers Dis. 2010;21(3):781-93. doi: 10.3233/JAD-2010-100159.

PMID:
20634584
[PubMed - indexed for MEDLINE]
9.

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.

Cell Calcium. 2006 Jun;39(6):539-50. Epub 2006 Apr 18.

PMID:
16620965
[PubMed - indexed for MEDLINE]
10.

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

J Clin Invest. 2007 May;117(5):1230-9. Epub 2007 Apr 12.

PMID:
17431506
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Membrane topology of human presenilin-1 in SK-N-SH cells determined by fluorescence correlation spectroscopy and fluorescent energy transfer.

Midde K, Rich R, Saxena A, Gryczynski I, Borejdo J, Das HK.

Cell Biochem Biophys. 2014 Nov;70(2):923-32. doi: 10.1007/s12013-014-9999-z.

PMID:
24839116
[PubMed - in process]
12.

The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.

Cedazo-Minguez A, Popescu BO, Ankarcrona M, Nishimura T, Cowburn RF.

J Biol Chem. 2002 Sep 27;277(39):36646-55. Epub 2002 Jul 16.

PMID:
12121968
[PubMed - indexed for MEDLINE]
Free Article
13.

Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.

Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.

J Alzheimers Dis. 2009;16(3):565-75. doi: 10.3233/JAD-2009-0990.

PMID:
19276551
[PubMed - indexed for MEDLINE]
14.

Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.

Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M.

J Neurosci. 2012 Aug 22;32(34):11820-34.

PMID:
22915123
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.

Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.

Nat Cell Biol. 1999 Dec;1(8):479-85.

PMID:
10587643
[PubMed - indexed for MEDLINE]
16.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
[PubMed - indexed for MEDLINE]
17.

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

Shilling D, Mak DO, Kang DE, Foskett JK.

J Biol Chem. 2012 Mar 30;287(14):10933-44. doi: 10.1074/jbc.M111.300491. Epub 2012 Feb 6.

PMID:
22311977
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.

Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J.

J Cell Mol Med. 2013 Feb;17(2):293-302. doi: 10.1111/jcmm.12008. Epub 2013 Feb 5.

PMID:
23379308
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM.

Pastorcic M, Das HK.

Brain Res. 2007 Jan 12;1128(1):21-32. Epub 2006 Nov 28.

PMID:
17126306
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells.

Kasri NN, Kocks SL, Verbert L, Hébert SS, Callewaert G, Parys JB, Missiaen L, De Smedt H.

Cell Calcium. 2006 Jul;40(1):41-51. Epub 2006 May 3.

PMID:
16675011
[PubMed - indexed for MEDLINE]
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