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Results: 1 to 20 of 68

1.

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function.

Moellendorf S, Kessels C, Peiseler L, Raupach A, Jacoby C, Vogt N, Lindecke A, Koch L, Brüning J, Heger J, Köhrer K, Gödecke A.

Am J Physiol Endocrinol Metab. 2012 Jul 15;303(2):E213-22. doi: 10.1152/ajpendo.00538.2011. Epub 2012 May 15.

PMID:
22589390
[PubMed - indexed for MEDLINE]
Free Article
2.

Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.

Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED.

Mol Endocrinol. 2008 Nov;22(11):2531-43. doi: 10.1210/me.2008-0265. Epub 2008 Sep 18.

PMID:
18801929
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells.

Bartucci M, Morelli C, Mauro L, Andò S, Surmacz E.

Cancer Res. 2001 Sep 15;61(18):6747-54.

PMID:
11559546
[PubMed - indexed for MEDLINE]
Free Article
4.

Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.

Sagara S, Osanai T, Itoh T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.

J Hypertens. 2012 Apr;30(4):778-86. doi: 10.1097/HJH.0b013e3283505101.

PMID:
22306848
[PubMed - indexed for MEDLINE]
5.

Cardiac-specific IGF-1 receptor transgenic expression protects against cardiac fibrosis and diastolic dysfunction in a mouse model of diabetic cardiomyopathy.

Huynh K, McMullen JR, Julius TL, Tan JW, Love JE, Cemerlang N, Kiriazis H, Du XJ, Ritchie RH.

Diabetes. 2010 Jun;59(6):1512-20. doi: 10.2337/db09-1456. Epub 2010 Mar 9.

PMID:
20215428
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Cardiac-specific overexpression of insulin-like growth factor 1 attenuates aging-associated cardiac diastolic contractile dysfunction and protein damage.

Li Q, Wu S, Li SY, Lopez FL, Du M, Kajstura J, Anversa P, Ren J.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1398-403. Epub 2006 Nov 3.

PMID:
17085535
[PubMed - indexed for MEDLINE]
Free Article
7.

Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action.

Fulzele K, DiGirolamo DJ, Liu Z, Xu J, Messina JL, Clemens TL.

J Biol Chem. 2007 Aug 31;282(35):25649-58. Epub 2007 Jun 6.

PMID:
17553792
[PubMed - indexed for MEDLINE]
Free Article
8.

Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: Roles of Akt, mTOR, GSK3beta, and PTEN.

Zhang B, Turdi S, Li Q, Lopez FL, Eason AR, Anversa P, Ren J.

Free Radic Biol Med. 2010 Oct 15;49(7):1238-53. doi: 10.1016/j.freeradbiomed.2010.07.020. Epub 2010 Aug 1.

PMID:
20678571
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.

Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R, Kahn CR.

Mol Cell Biol. 2007 Mar;27(5):1649-64. Epub 2006 Dec 22.

PMID:
17189427
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo study.

Shukla S, Gupta S.

Mol Carcinog. 2009 Mar;48(3):243-52. doi: 10.1002/mc.20475.

PMID:
18726972
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.

Ikeda H, Shiojima I, Ozasa Y, Yoshida M, Holzenberger M, Kahn CR, Walsh K, Igarashi T, Abel ED, Komuro I.

J Mol Cell Cardiol. 2009 Nov;47(5):664-75. doi: 10.1016/j.yjmcc.2009.08.028. Epub 2009 Sep 8.

PMID:
19744489
[PubMed - indexed for MEDLINE]
12.

Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression.

Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi I, Zias E, Walsh K, Rosenzweig A, Sussman MA, Urbanek K, Nadal-Ginard B, Kajstura J, Anversa P, Leri A.

Circ Res. 2004 Mar 5;94(4):514-24. Epub 2004 Jan 15.

PMID:
14726476
[PubMed - indexed for MEDLINE]
Free Article
13.

Aging impairs IGF-I receptor activation and induces skeletal resistance to IGF-I.

Cao JJ, Kurimoto P, Boudignon B, Rosen C, Lima F, Halloran BP.

J Bone Miner Res. 2007 Aug;22(8):1271-9.

PMID:
17488198
[PubMed - indexed for MEDLINE]
14.

Neutral endopeptidase inhibits neuropeptide-mediated transactivation of the insulin-like growth factor receptor-Akt cell survival pathway.

Sumitomo M, Milowsky MI, Shen R, Navarro D, Dai J, Asano T, Hayakawa M, Nanus DM.

Cancer Res. 2001 Apr 15;61(8):3294-8.

PMID:
11309283
[PubMed - indexed for MEDLINE]
Free Article
15.

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A.

Scalia P, Heart E, Comai L, Vigneri R, Sung CK.

J Cell Biochem. 2001;82(4):610-8.

PMID:
11500939
[PubMed - indexed for MEDLINE]
16.

A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival.

Knezevic I, Patel A, Sundaresan NR, Gupta MP, Solaro RJ, Nagalingam RS, Gupta M.

J Biol Chem. 2012 Apr 13;287(16):12913-26. doi: 10.1074/jbc.M111.331751. Epub 2012 Feb 24.

PMID:
22367207
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.

Tang Q, Cai J, Shen D, Bian Z, Yan L, Wang YX, Lan J, Zhuang GQ, Ma WZ, Wang W.

J Mol Med (Berl). 2009 Mar;87(3):249-60. doi: 10.1007/s00109-008-0423-2. Epub 2008 Dec 19.

PMID:
19096818
[PubMed - indexed for MEDLINE]
18.

Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1.

Thum T, Hoeber S, Froese S, Klink I, Stichtenoth DO, Galuppo P, Jakob M, Tsikas D, Anker SD, Poole-Wilson PA, Borlak J, Ertl G, Bauersachs J.

Circ Res. 2007 Feb 16;100(3):434-43. Epub 2007 Jan 18.

PMID:
17234973
[PubMed - indexed for MEDLINE]
Free Article
19.

Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells.

Desbois-Mouthon C, Blivet-Van Eggelpoël MJ, Beurel E, Boissan M, Delélo R, Cadoret A, Capeau J.

Hepatology. 2002 Dec;36(6):1528-36.

PMID:
12447879
[PubMed - indexed for MEDLINE]
20.

Metallothionein antagonizes aging-induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt.

Fang CX, Doser TA, Yang X, Sreejayan N, Ren J.

Aging Cell. 2006 Apr;5(2):177-85.

PMID:
16626396
[PubMed - indexed for MEDLINE]

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