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Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.

Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN.

Free Radic Biol Med. 2012 Jul 1;53(1):51-9. doi: 10.1016/j.freeradbiomed.2012.04.024. Epub 2012 May 1.


An oxidative DNA "damage" and repair mechanism localized in the VEGF promoter is important for hypoxia-induced VEGF mRNA expression.

Pastukh V, Roberts JT, Clark DW, Bardwell GC, Patel M, Al-Mehdi AB, Borchert GM, Gillespie MN.

Am J Physiol Lung Cell Mol Physiol. 2015 Dec 1;309(11):L1367-75. doi: 10.1152/ajplung.00236.2015. Epub 2015 Oct 2.


Sequence-specific oxidative base modifications in hypoxia-inducible genes.

Pastukh V, Ruchko M, Gorodnya O, Wilson GL, Gillespie MN.

Free Radic Biol Med. 2007 Dec 15;43(12):1616-26. Epub 2007 Sep 9.


Oxidative DNA modifications in hypoxic signaling.

Gillespie MN, Pastukh V, Ruchko MV.

Ann N Y Acad Sci. 2009 Oct;1177:140-50. doi: 10.1111/j.1749-6632.2009.05036.x.


G-quadruplex (G4) motifs in the maize (Zea mays L.) genome are enriched at specific locations in thousands of genes coupled to energy status, hypoxia, low sugar, and nutrient deprivation.

Andorf CM, Kopylov M, Dobbs D, Koch KE, Stroupe ME, Lawrence CJ, Bass HW.

J Genet Genomics. 2014 Dec 20;41(12):627-47. doi: 10.1016/j.jgg.2014.10.004. Epub 2014 Nov 4.


Solution equilibria of cytosine- and guanine-rich sequences near the promoter region of the n-myc gene that contain stable hairpins within lateral loops.

Benabou S, Ferreira R, Aviñó A, González C, Lyonnais S, Solà M, Eritja R, Jaumot J, Gargallo R.

Biochim Biophys Acta. 2014 Jan;1840(1):41-52. doi: 10.1016/j.bbagen.2013.08.028. Epub 2013 Sep 6.


Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.

Zhou W, Suntharalingam K, Brand NJ, Barton PJ, Vilar R, Ying L.

PLoS One. 2013;8(1):e53137. doi: 10.1371/journal.pone.0053137. Epub 2013 Jan 9.


Oxidants in signal transduction: impact on DNA integrity and gene expression.

Ziel KA, Grishko V, Campbell CC, Breit JF, Wilson GL, Gillespie MN.

FASEB J. 2005 Mar;19(3):387-94.


Spontaneous DNA lesions modulate DNA structural transitions occurring at nuclease hypersensitive element III(1) of the human c-myc proto-oncogene.

Beckett J, Burns J, Broxson C, Tornaletti S.

Biochemistry. 2012 Jul 3;51(26):5257-68. Epub 2012 Jun 19.


Characterization of oxidative guanine damage and repair in mammalian telomeres.

Wang Z, Rhee DB, Lu J, Bohr CT, Zhou F, Vallabhaneni H, de Souza-Pinto NC, Liu Y.

PLoS Genet. 2010 May 13;6(5):e1000951. doi: 10.1371/journal.pgen.1000951.


Zinc-finger transcription factors are associated with guanine quadruplex motifs in human, chimpanzee, mouse and rat promoters genome-wide.

Kumar P, Yadav VK, Baral A, Kumar P, Saha D, Chowdhury S.

Nucleic Acids Res. 2011 Oct;39(18):8005-16. doi: 10.1093/nar/gkr536. Epub 2011 Jul 4.


Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions.

Qin Y, Hurley LH.

Biochimie. 2008 Aug;90(8):1149-71. doi: 10.1016/j.biochi.2008.02.020. Epub 2008 Feb 29. Review.


G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

Cogoi S, Xodo LE.

Nucleic Acids Res. 2006 May 10;34(9):2536-49. Print 2006.


Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1.

Huang W, Smaldino PJ, Zhang Q, Miller LD, Cao P, Stadelman K, Wan M, Giri B, Lei M, Nagamine Y, Vaughn JP, Akman SA, Sui G.

Nucleic Acids Res. 2012 Feb;40(3):1033-49. doi: 10.1093/nar/gkr849. Epub 2011 Oct 12.


G-quadruplexes in promoters throughout the human genome.

Huppert JL, Balasubramanian S.

Nucleic Acids Res. 2007;35(2):406-13. Epub 2006 Dec 14. Erratum in: Nucleic Acids Res. 2007;35(6):2105.


G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.

Fleming AM, Burrows CJ.

Chem Res Toxicol. 2013 Apr 15;26(4):593-607. doi: 10.1021/tx400028y. Epub 2013 Mar 13.


Enhancer-promoter interaction facilitated by transiently forming G-quadruplexes.

Hegyi H.

Sci Rep. 2015 Mar 16;5:9165. doi: 10.1038/srep09165.


G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.

Membrino A, Cogoi S, Pedersen EB, Xodo LE.

PLoS One. 2011;6(9):e24421. doi: 10.1371/journal.pone.0024421. Epub 2011 Sep 8.

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