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Results: 1 to 20 of 101

1.

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109. Epub 2012 May 7.

PMID:
22566624
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The expression and function of microRNAs in chondrogenesis and osteoarthritis.

Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A, Dalmay T, Young DA, Clark IM.

Arthritis Rheum. 2012 Jun;64(6):1909-19. doi: 10.1002/art.34314. Epub 2011 Dec 5.

PMID:
22143896
[PubMed - indexed for MEDLINE]
Free Article
3.

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.

Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkársdóttir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB.

Arthritis Rheum. 2010 Feb;62(2):499-510. doi: 10.1002/art.27184.

PMID:
20112360
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis in STR/ort mice.

Pasold J, Osterberg A, Peters K, Taipaleenmäki H, Säämänen AM, Vollmar B, Müller-Hilke B.

Exp Cell Res. 2013 Mar 10;319(5):649-59. doi: 10.1016/j.yexcr.2012.12.012. Epub 2012 Dec 21.

PMID:
23261541
[PubMed - indexed for MEDLINE]
5.

Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis.

Leijten JC, Emons J, Sticht C, van Gool S, Decker E, Uitterlinden A, Rappold G, Hofman A, Rivadeneira F, Scherjon S, Wit JM, van Meurs J, van Blitterswijk CA, Karperien M.

Arthritis Rheum. 2012 Oct;64(10):3302-12. doi: 10.1002/art.34535.

PMID:
22576962
[PubMed - indexed for MEDLINE]
Free Article
6.

Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.

Evans DS, Cailotto F, Parimi N, Valdes AM, Castaño-Betancourt MC, Liu Y, Kaplan RC, Bidlingmaier M, Vasan RS, Teumer A, Tranah GJ, Nevitt MC, Cummings SR, Orwoll ES, Barrett-Connor E, Renner JB, Jordan JM, Doherty M, Doherty SA, Uitterlinden AG, van Meurs JB, Spector TD, Lories RJ, Lane NE.

Ann Rheum Dis. 2014 Jun 13. pii: annrheumdis-2013-205020. doi: 10.1136/annrheumdis-2013-205020. [Epub ahead of print]

PMID:
24928840
[PubMed - as supplied by publisher]
7.

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice.

Lodewyckx L, Cailotto F, Thysen S, Luyten FP, Lories RJ.

Arthritis Res Ther. 2012 Jan 20;14(1):R16. doi: 10.1186/ar3695.

PMID:
22264237
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

Takamatsu A, Ohkawara B, Ito M, Masuda A, Sakai T, Ishiguro N, Ohno K.

PLoS One. 2014 Mar 21;9(3):e92699. doi: 10.1371/journal.pone.0092699. eCollection 2014.

PMID:
24658359
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males.

Evangelou E, Valdes AM, Castano-Betancourt MC, Doherty M, Doherty S, Esko T, Ingvarsson T, Ioannidis JP, Kloppenburg M, Metspalu A, Ntzani EE, Panoutsopoulou K, Slagboom PE, Southam L, Spector TD, Styrkarsdottir U, Stefanson K, Uitterlinden AG, Wheeler M, Zeggini E, Meulenbelt I, van Meurs JB; arcOGEN consortium, the TREAT-OA consortium.

Ann Rheum Dis. 2013 Jul;72(7):1264-5. doi: 10.1136/annrheumdis-2012-203182. Epub 2013 Mar 16. No abstract available.

PMID:
23505243
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese.

Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, Kotani A, Kubo T, Nakamura K, Sekine A, Murakami Y, Tsunoda T, Notoya K, Nakamura Y, Ikegawa S.

Hum Mol Genet. 2005 Apr 15;14(8):1009-17. Epub 2005 Mar 3.

PMID:
15746150
[PubMed - indexed for MEDLINE]
Free Article
11.

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1.

Blom AB, Brockbank SM, van Lent PL, van Beuningen HM, Geurts J, Takahashi N, van der Kraan PM, van de Loo FA, Schreurs BW, Clements K, Newham P, van den Berg WB.

Arthritis Rheum. 2009 Feb;60(2):501-12. doi: 10.1002/art.24247.

PMID:
19180479
[PubMed - indexed for MEDLINE]
Free Article
12.

Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population.

Mototani H, Iida A, Nakamura Y, Ikegawa S.

J Bone Miner Metab. 2010 Sep;28(5):547-53. doi: 10.1007/s00774-010-0161-8. Epub 2010 Mar 3.

PMID:
20198394
[PubMed - indexed for MEDLINE]
13.

Altered in vitro chondrogenic properties of chondrocytes harvested from unaffected cartilage in osteoarthritic joints.

Yang KG, Saris DB, Geuze RE, van Rijen MH, van der Helm YJ, Verbout AJ, Creemers LB, Dhert WJ.

Osteoarthritis Cartilage. 2006 Jun;14(6):561-70.

PMID:
16735197
[PubMed - indexed for MEDLINE]
Free Article
14.

Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function.

van de Loo FA, Veenbergen S, van den Brand B, Bennink MB, Blaney-Davidson E, Arntz OJ, van Beuningen HM, van der Kraan PM, van den Berg WB.

Arthritis Rheum. 2012 Oct;64(10):3313-23. doi: 10.1002/art.34529.

PMID:
22576756
[PubMed - indexed for MEDLINE]
Free Article
15.

Osteoarthritis year 2013 in review: genetics and genomics.

Gonzalez A.

Osteoarthritis Cartilage. 2013 Oct;21(10):1443-51. doi: 10.1016/j.joca.2013.07.001. Epub 2013 Jul 8. Review.

PMID:
23845519
[PubMed - indexed for MEDLINE]
Free Article
16.

Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: identification of sorting nexin 19 as a novel factor.

Kan A, Ikeda T, Saito T, Yano F, Fukai A, Hojo H, Ogasawara T, Ogata N, Nakamura K, Chung UI, Kawaguchi H.

Arthritis Rheum. 2009 Nov;60(11):3314-23. doi: 10.1002/art.24878.

PMID:
19877062
[PubMed - indexed for MEDLINE]
Free Article
17.

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.

Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD, Esko T, Evans DS, Metrustry S, Panoutsopoulou K, Ramos YF, Thorleifsson G, Tsilidis KK; arcOGEN Consortium, Arden N, Aslam N, Bellamy N, Birrell F, Blanco FJ, Carr A, Chapman K, Day-Williams AG, Deloukas P, Doherty M, Engström G, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Keurentjes JC, Kloppenburg M, Lind PA, McCaskie A, Martin NG, Milani L, Montgomery GW, Nelissen RG, Nevitt MC, Nilsson PM, Ollier WE, Parimi N, Rai A, Ralston SH, Reed MR, Riancho JA, Rivadeneira F, Rodriguez-Fontenla C, Southam L, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Gonzalez A, Lane NE, Lohmander LS, Loughlin J, Metspalu A, Uitterlinden AG, Jonsdottir I, Stefansson K, Slagboom PE, Zeggini E, Meulenbelt I, Ioannidis JP, Spector TD, van Meurs JB, Valdes AM.

Ann Rheum Dis. 2014 Dec;73(12):2130-6. doi: 10.1136/annrheumdis-2012-203114. Epub 2013 Aug 29. Review.

PMID:
23989986
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Subtractive gene expression profiling of articular cartilage and mesenchymal stem cells: serpins as cartilage-relevant differentiation markers.

Boeuf S, Steck E, Pelttari K, Hennig T, Buneb A, Benz K, Witte D, Sültmann H, Poustka A, Richter W.

Osteoarthritis Cartilage. 2008 Jan;16(1):48-60. Epub 2007 Jul 2.

PMID:
17604188
[PubMed - indexed for MEDLINE]
Free Article
19.

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.

Ho LL, Sinha A, Verzi M, Bernt KM, Armstrong SA, Shivdasani RA.

Mol Cell Biol. 2013 May;33(9):1735-45. doi: 10.1128/MCB.01463-12. Epub 2013 Feb 19.

PMID:
23428873
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation.

Monfort J, Garcia-Giralt N, López-Armada MJ, Monllau JC, Bonilla A, Benito P, Blanco FJ.

Arthritis Res Ther. 2006;8(5):R149.

PMID:
16972994
[PubMed - indexed for MEDLINE]
Free PMC Article
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