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Results: 1 to 20 of 168

Similar articles for PubMed (Select 22554036)

1.

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.

Wang Y, Arvanites AC, Davidow L, Blanchard J, Lam K, Yoo JW, Coy S, Rubin LL, McMahon AP.

ACS Chem Biol. 2012 Jun 15;7(6):1040-8. doi: 10.1021/cb300028a. Epub 2012 May 3.

2.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Peluso MO, Campbell VT, Harari JA, Tibbitts TT, Proctor JL, Whitebread N, Conley JM, White KF, Kutok JL, Read MA, McGovern K, Faia KL.

PLoS One. 2014 Mar 7;9(3):e90534. doi: 10.1371/journal.pone.0090534. eCollection 2014.

3.

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation.

Wang Y, Zhou Z, Walsh CT, McMahon AP.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2623-8. doi: 10.1073/pnas.0812110106. Epub 2009 Feb 5.

4.

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity.

Wang Y, Davidow L, Arvanites AC, Blanchard J, Lam K, Xu K, Oza V, Yoo JW, Ng JM, Curran T, Rubin LL, McMahon AP.

Chem Biol. 2012 Aug 24;19(8):972-82. doi: 10.1016/j.chembiol.2012.06.012.

5.

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.

Wu VM, Chen SC, Arkin MR, Reiter JF.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13644-9. doi: 10.1073/pnas.1207170109. Epub 2012 Aug 3.

6.

Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.

Bijlsma MF, Damhofer H, Roelink H.

Sci Signal. 2012 Aug 21;5(238):ra60. doi: 10.1126/scisignal.2002798.

7.

Vertebrate Smoothened functions at the primary cilium.

Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF.

Nature. 2005 Oct 13;437(7061):1018-21. Epub 2005 Aug 31.

PMID:
16136078
8.

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

Yang C, Chen W, Chen Y, Jiang J.

Cell Res. 2012 Nov;22(11):1593-604. doi: 10.1038/cr.2012.134. Epub 2012 Sep 18.

9.

The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.

Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW.

J Hepatol. 2014 Jan;60(1):143-51. doi: 10.1016/j.jhep.2013.08.012. Epub 2013 Aug 23.

PMID:
23978713
10.

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

Wilson CW, Chen MH, Chuang PT.

PLoS One. 2009;4(4):e5182. doi: 10.1371/journal.pone.0005182. Epub 2009 Apr 13.

11.

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.

Chong YC, Mann RK, Zhao C, Kato M, Beachy PA.

Genes Dev. 2015 Feb 1;29(3):262-76. doi: 10.1101/gad.252676.114.

PMID:
25644602
12.

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process.

Rohatgi R, Milenkovic L, Corcoran RB, Scott MP.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3196-201. doi: 10.1073/pnas.0813373106. Epub 2009 Feb 13.

13.

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia.

Caparrós-Martín JA, Valencia M, Reytor E, Pacheco M, Fernandez M, Perez-Aytes A, Gean E, Lapunzina P, Peters H, Goodship JA, Ruiz-Perez VL.

Hum Mol Genet. 2013 Jan 1;22(1):124-39. doi: 10.1093/hmg/dds409. Epub 2012 Oct 1.

14.

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.

Chen Y, Sasai N, Ma G, Yue T, Jia J, Briscoe J, Jiang J.

PLoS Biol. 2011 Jun;9(6):e1001083. doi: 10.1371/journal.pbio.1001083. Epub 2011 Jun 14.

15.

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling.

Aanstad P, Santos N, Corbit KC, Scherz PJ, Trinh le A, Salvenmoser W, Huisken J, Reiter JF, Stainier DY.

Curr Biol. 2009 Jun 23;19(12):1034-9. doi: 10.1016/j.cub.2009.04.053. Epub 2009 May 21.

16.

Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics.

Peukert S, Miller-Moslin K.

ChemMedChem. 2010 Apr 6;5(4):500-12. doi: 10.1002/cmdc.201000011. Review.

PMID:
20229564
17.

A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia.

Dorn KV, Hughes CE, Rohatgi R.

Dev Cell. 2012 Oct 16;23(4):823-35. doi: 10.1016/j.devcel.2012.07.004. Epub 2012 Sep 13.

18.

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.

19.

Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1.

Lu J, Chen M, Ren XR, Wang J, Lyerly HK, Barak L, Chen W.

PLoS One. 2013 May 3;8(5):e63353. doi: 10.1371/journal.pone.0063353. Print 2013.

20.

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.

Kim J, Kato M, Beachy PA.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21666-71. doi: 10.1073/pnas.0912180106. Epub 2009 Dec 8.

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