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Results: 1 to 20 of 104

1.

Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.

Perez OD, Logg CR, Hiraoka K, Diago O, Burnett R, Inagaki A, Jolson D, Amundson K, Buckley T, Lohse D, Lin A, Burrascano C, Ibanez C, Kasahara N, Gruber HE, Jolly DJ.

Mol Ther. 2012 Sep;20(9):1689-98. doi: 10.1038/mt.2012.83. Epub 2012 May 1. Erratum in: Mol Ther. 2013 Feb;21(2):494.

PMID:
22547150
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.

Ostertag D, Amundson KK, Lopez Espinoza F, Martin B, Buckley T, Galvão da Silva AP, Lin AH, Valenta DT, Perez OD, Ibañez CE, Chen CI, Pettersson PL, Burnett R, Daublebsky V, Hlavaty J, Gunzburg W, Kasahara N, Gruber HE, Jolly DJ, Robbins JM.

Neuro Oncol. 2012 Feb;14(2):145-59. doi: 10.1093/neuonc/nor199. Epub 2011 Nov 9.

PMID:
22070930
[PubMed - indexed for MEDLINE]
Free PMC Article
3.
4.

Replicating retroviral vectors for oncolytic virotherapy of experimental hepatocellular carcinoma.

Lu YC, Chen YJ, Yu YR, Lai YH, Cheng JC, Li YF, Shen CH, Tai CK.

Oncol Rep. 2012 Jul;28(1):21-6. doi: 10.3892/or.2012.1789. Epub 2012 Apr 26.

PMID:
22552490
[PubMed - indexed for MEDLINE]
5.

Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine.

Stolworthy TS, Korkegian AM, Willmon CL, Ardiani A, Cundiff J, Stoddard BL, Black ME.

J Mol Biol. 2008 Mar 28;377(3):854-69. doi: 10.1016/j.jmb.2008.01.002. Epub 2008 Jan 11.

PMID:
18291415
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Oncolytic herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation.

Yamada S, Kuroda T, Fuchs BC, He X, Supko JG, Schmitt A, McGinn CM, Lanuti M, Tanabe KK.

Cancer Gene Ther. 2012 Mar;19(3):160-70. doi: 10.1038/cgt.2011.70. Epub 2011 Nov 11.

PMID:
22076044
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.

Hirschowitz EA, Ohwada A, Pascal WR, Russi TJ, Crystal RG.

Hum Gene Ther. 1995 Aug;6(8):1055-63.

PMID:
7578418
[PubMed - indexed for MEDLINE]
8.

Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.

Nakamura H, Mullen JT, Chandrasekhar S, Pawlik TM, Yoon SS, Tanabe KK.

Cancer Res. 2001 Jul 15;61(14):5447-52.

PMID:
11454690
[PubMed - indexed for MEDLINE]
Free Article
9.

Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.

Huang TT, Hlavaty J, Ostertag D, Espinoza FL, Martin B, Petznek H, Rodriguez-Aguirre M, Ibañez CE, Kasahara N, Gunzburg W, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM.

Cancer Gene Ther. 2013 Oct;20(10):544-51. doi: 10.1038/cgt.2013.51. Epub 2013 Aug 23.

PMID:
23969884
[PubMed - indexed for MEDLINE]
10.

Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression.

Dubois L, Dresselaers T, Landuyt W, Paesmans K, Mengesha A, Wouters BG, Van Hecke P, Theys J, Lambin P.

Br J Cancer. 2007 Mar 12;96(5):758-61. Epub 2007 Feb 20.

PMID:
17311022
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Exogenous cytosine deaminase gene expression in Bifidobacterium breve I-53-8w for tumor-targeting enzyme/prodrug therapy.

Hidaka A, Hamaji Y, Sasaki T, Taniguchi S, Fujimori M.

Biosci Biotechnol Biochem. 2007 Dec;71(12):2921-6.

PMID:
18159091
[PubMed - indexed for MEDLINE]
Free Article
12.

Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus.

Kubo S, Takagi-Kimura M, Logg CR, Kasahara N.

Cancer Gene Ther. 2013 Dec;20(12):671-7. doi: 10.1038/cgt.2013.67. Epub 2013 Nov 8.

PMID:
24201868
[PubMed - indexed for MEDLINE]
13.

Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation.

Garcia-Sanchez F, Pizzorno G, Fu SQ, Nanakorn T, Krause DS, Liang J, Adams E, Leffert JJ, Yin LH, Cooperberg MR, Hanania E, Wang WL, Won JH, Peng XY, Cote R, Brown R, Burtness B, Giles R, Crystal R, Deisseroth AB.

Blood. 1998 Jul 15;92(2):672-82.

PMID:
9657770
[PubMed - indexed for MEDLINE]
Free Article
14.

Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-β via their tumor tropism to selectively target human hepatocarcinoma cells.

Yi BR, Hwang KA, Kang NH, Kim SU, Jeung EB, Kim HC, Choi KC.

Cancer Gene Ther. 2012 Sep;19(9):644-51. doi: 10.1038/cgt.2012.45. Epub 2012 Jul 13.

PMID:
22790964
[PubMed - indexed for MEDLINE]
15.

[Antitumor activity of the recombinant rClone30-CD/5-FC system].

Lu Z, Zhang TY, Han MM, Bai FL, Wu W, Tian GY, Ren GP, Li DS.

Yao Xue Xue Bao. 2013 Feb;48(2):261-8. Chinese.

PMID:
23672024
[PubMed - indexed for MEDLINE]
16.

Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy.

Kucerova L, Altanerova V, Matuskova M, Tyciakova S, Altaner C.

Cancer Res. 2007 Jul 1;67(13):6304-13.

PMID:
17616689
[PubMed - indexed for MEDLINE]
Free Article
17.

Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy.

Wang D, Ruan H, Hu L, Lamborn KR, Kong EL, Rehemtulla A, Deen DF.

Cancer Gene Ther. 2005 Mar;12(3):276-83.

PMID:
15650767
[PubMed - indexed for MEDLINE]
18.

Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model.

You MH, Kim WJ, Shim W, Lee SR, Lee G, Choi S, Kim DY, Kim YM, Kim H, Han SU.

J Gastroenterol Hepatol. 2009 Aug;24(8):1393-400. doi: 10.1111/j.1440-1746.2009.05862.x. Epub 2009 May 28.

PMID:
19486256
[PubMed - indexed for MEDLINE]
19.

Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.

Miller CR, Williams CR, Buchsbaum DJ, Gillespie GY.

Cancer Res. 2002 Feb 1;62(3):773-80.

PMID:
11830532
[PubMed - indexed for MEDLINE]
Free Article
20.

Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer.

Fogar P, Navaglia F, Basso D, Greco E, Zambon CF, Fadi E, Falda A, Stranges A, Vannozzi F, Danesi R, Pedrazzoli S, Plebani M.

Pancreas. 2007 Oct;35(3):224-31.

PMID:
17895842
[PubMed - indexed for MEDLINE]

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