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Items: 1 to 20 of 113

1.

Mitotane exhibits dual effects on steroidogenic enzymes gene transcription under basal and cAMP-stimulating microenvironments in NCI-H295 cells.

Lin CW, Chang YH, Pu HF.

Toxicology. 2012 Aug 16;298(1-3):14-23. doi: 10.1016/j.tox.2012.04.007. Epub 2012 Apr 23.

PMID:
22546480
2.

Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane.

van Koetsveld PM, Vitale G, Feelders RA, Waaijers M, Sprij-Mooij DM, de Krijger RR, Speel EJ, Hofland J, Lamberts SW, de Herder WW, Hofland LJ.

Endocr Relat Cancer. 2013 May 30;20(3):443-54. doi: 10.1530/ERC-12-0217. Print 2013 Jun.

3.

Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.

Staels B, Martin G, Martinez M, Albert C, Peinado-Onsurbe J, Saladin R, Hum DW, Reina M, Vilaro S, Auwerx J.

J Biol Chem. 1996 Jul 19;271(29):17425-32.

4.

Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.

Sbiera S, Leich E, Liebisch G, Sbiera I, Schirbel A, Wiemer L, Matysik S, Eckhardt C, Gardill F, Gehl A, Kendl S, Weigand I, Bala M, Ronchi CL, Deutschbein T, Schmitz G, Rosenwald A, Allolio B, Fassnacht M, Kroiss M.

Endocrinology. 2015 Nov;156(11):3895-908. doi: 10.1210/en.2015-1367. Epub 2015 Aug 25.

PMID:
26305886
5.

Inhibitory effects of digoxin and ouabain on aldosterone synthesis in human adrenocortical NCI-H295 cells.

Kau MM, Kan SF, Wang JR, Wang PS.

J Cell Physiol. 2005 Dec;205(3):393-401.

PMID:
15887230
6.

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal.

Staels B, Hum DW, Miller WL.

Mol Endocrinol. 1993 Mar;7(3):423-33.

PMID:
8387159
7.

The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells.

Lehmann TP, Wrzesiński T, Jagodziński PP.

Mol Med Rep. 2013 Mar;7(3):893-900. doi: 10.3892/mmr.2012.1244. Epub 2012 Dec 18.

PMID:
23254310
8.

Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells.

Martin G, Pilon A, Albert C, Vallé M, Hum DW, Fruchart JC, Najib J, Clavey V, Staels B.

Eur J Biochem. 1999 Apr;261(2):481-91.

9.

Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells.

Wenzel J, Grabinski N, Knopp CA, Dendorfer A, Ramanjaneya M, Randeva HS, Ehrhart-Bornstein M, Dominiak P, Jöhren O.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1601-9. doi: 10.1152/ajpregu.91034.2008. Epub 2009 Sep 30.

10.

In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.

Enberg U, Farnebo LO, Wedell A, Gröndal S, Thorén M, Grimelius L, Kjellman M, Bäckdahl M, Hamberger B.

World J Surg. 2001 Jul;25(7):957-66.

PMID:
11572038
12.

Aminoglutethimide suppresses adrenocorticotropin receptor expression in the NCI-h295 adrenocortical tumor cell line.

Fassnacht M, Beuschlein F, Vay S, Mora P, Allolio B, Reincke M.

J Endocrinol. 1998 Oct;159(1):35-42.

13.

Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells.

Kau MM, Wang JR, Tsai SC, Yu CH, Wang PS.

Br J Pharmacol. 2012 Mar;165(6):1868-76. doi: 10.1111/j.1476-5381.2011.01671.x.

14.

Steroidogenic acute regulatory protein mRNA expression in adrenal tumours.

Zenkert S, Schubert B, Fassnacht M, Beuschlein F, Allolio B, Reincke M.

Eur J Endocrinol. 2000 Mar;142(3):294-9.

15.

Effects of mitotane on gene expression in the adrenocortical cell line NCI-H295R: a microarray study.

Zsippai A, Szabó DR, Tömböl Z, Szabó PM, Eder K, Pállinger E, Gaillard RC, Patócs A, Tóth S, Falus A, Rácz K, Igaz P.

Pharmacogenomics. 2012 Sep;13(12):1351-61. doi: 10.2217/pgs.12.116.

PMID:
22966885
16.

Modulation of proteomic profile in H295R adrenocortical cell line induced by mitotane.

Stigliano A, Cerquetti L, Borro M, Gentile G, Bucci B, Misiti S, Piergrossi P, Brunetti E, Simmaco M, Toscano V.

Endocr Relat Cancer. 2008 Mar;15(1):1-10. doi: 10.1677/ERC-07-0003.

17.

New mechanisms of adrenostatic compounds in a human adrenocortical cancer cell line.

Fassnacht M, Hahner S, Beuschlein F, Klink A, Reincke M, Allolio B.

Eur J Clin Invest. 2000 Dec;30 Suppl 3:76-82. Review.

PMID:
11281374
18.

Mitotane enhances doxorubicin cytotoxic activity by inhibiting P-gp in human adrenocortical carcinoma cells.

Gagliano T, Gentilin E, Benfini K, Di Pasquale C, Tassinari M, Falletta S, Feo C, Tagliati F, Uberti ED, Zatelli MC.

Endocrine. 2014 Dec;47(3):943-51. doi: 10.1007/s12020-014-0374-z. Epub 2014 Aug 6.

PMID:
25096913
19.

Mitotane alters mitochondrial respiratory chain activity by inducing cytochrome c oxidase defect in human adrenocortical cells.

Hescot S, Slama A, Lombès A, Paci A, Remy H, Leboulleux S, Chadarevian R, Trabado S, Amazit L, Young J, Baudin E, Lombès M.

Endocr Relat Cancer. 2013 May 21;20(3):371-81. doi: 10.1530/ERC-12-0368. Print 2013 Jun.

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