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RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.

Wu J, Liu C, Chen J, Yu X.

J Biol Chem. 2012 Jun 29;287(27):22919-26. doi: 10.1074/jbc.M112.351007. Epub 2012 Apr 25.


MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

Shao G, Patterson-Fortin J, Messick TE, Feng D, Shanbhag N, Wang Y, Greenberg RA.

Genes Dev. 2009 Mar 15;23(6):740-54. doi: 10.1101/gad.1739609. Epub 2009 Mar 4.


Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates.

Hu X, Paul A, Wang B.

J Biol Chem. 2012 Jul 20;287(30):25510-9. doi: 10.1074/jbc.M112.374116. Epub 2012 Jun 11.


Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.

Kim H, Chen J, Yu X.

Science. 2007 May 25;316(5828):1202-5.


The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.

Yan J, Kim YS, Yang XP, Li LP, Liao G, Xia F, Jetten AM.

Cancer Res. 2007 Jul 15;67(14):6647-56. Epub 2007 Jul 9.


RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.

Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ.

Sci Signal. 2012 Dec 4;5(253):ra88. doi: 10.1126/scisignal.2003485.


Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.

Wang B, Elledge SJ.

Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20759-63. Epub 2007 Dec 5.


RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA.

Science. 2007 May 25;316(5828):1198-202.


Loss of BRCA1-A complex function in RAP80 null tumor cells.

Bian C, Wu R, Cho K, Yu X.

PLoS One. 2012;7(7):e40406. doi: 10.1371/journal.pone.0040406. Epub 2012 Jul 6.


The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.

Coleman KA, Greenberg RA.

J Biol Chem. 2011 Apr 15;286(15):13669-80. doi: 10.1074/jbc.M110.213728. Epub 2011 Feb 18.


RAP80 is critical in maintaining genomic stability and suppressing tumor development.

Yin Z, Menendez D, Resnick MA, French JE, Janardhan KS, Jetten AM.

Cancer Res. 2012 Oct 1;72(19):5080-90. doi: 10.1158/0008-5472.CAN-12-1484. Epub 2012 Aug 15.


Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80.

Sato Y, Yoshikawa A, Mimura H, Yamashita M, Yamagata A, Fukai S.

EMBO J. 2009 Aug 19;28(16):2461-8. doi: 10.1038/emboj.2009.160. Epub 2009 Jun 18.


Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.

Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA.

Oncogene. 2009 Apr 23;28(16):1843-52. doi: 10.1038/onc.2009.33. Epub 2009 Mar 23.


RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites.

Yan J, Jetten AM.

Cancer Lett. 2008 Nov 28;271(2):179-90. doi: 10.1016/j.canlet.2008.04.046. Epub 2008 Jun 11. Review.


E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20876-81. doi: 10.1073/pnas.0811203106. Epub 2008 Dec 16.


MERIT40 facilitates BRCA1 localization and DNA damage repair.

Feng L, Huang J, Chen J.

Genes Dev. 2009 Mar 15;23(6):719-28. doi: 10.1101/gad.1770609. Epub 2009 Mar 4.


RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.

Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM.

Genes Dev. 2011 Apr 1;25(7):685-700. doi: 10.1101/gad.2011011. Epub 2011 Mar 15.


RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage.

Iijima J, Zeng Z, Takeda S, Taniguchi Y.

Cancer Res. 2010 Nov 1;70(21):8467-74. doi: 10.1158/0008-5472.CAN-10-0267. Epub 2010 Oct 19.


BRCA1, a 'complex' protein involved in the maintenance of genomic stability.

Savage KI, Harkin DP.

FEBS J. 2015 Feb;282(4):630-46. doi: 10.1111/febs.13150. Epub 2014 Dec 2. Review.


Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks.

De la Torre C, Pincheira J, López-Sáez JF.

Histol Histopathol. 2003 Jan;18(1):225-43. Review.

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