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Results: 1 to 20 of 105

1.

Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.

Burkard A, Dähn C, Heinz S, Zutavern A, Sonntag-Buck V, Maltman D, Przyborski S, Hewitt NJ, Braspenning J.

Xenobiotica. 2012 Oct;42(10):939-56. doi: 10.3109/00498254.2012.675093. Epub 2012 Apr 24.

PMID:
22524704
[PubMed - indexed for MEDLINE]
2.

Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions.

Abadie-Viollon C, Martin H, Blanchard N, Pekthong D, Bachellier P, Mantion G, Heyd B, Schuler F, Coassolo P, Alexandre E, Richert L.

Toxicol In Vitro. 2010 Feb;24(1):346-56. doi: 10.1016/j.tiv.2009.05.021. Epub 2009 Jun 2.

PMID:
19497360
[PubMed - indexed for MEDLINE]
3.

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.

Gerets HH, Tilmant K, Gerin B, Chanteux H, Depelchin BO, Dhalluin S, Atienzar FA.

Cell Biol Toxicol. 2012 Apr;28(2):69-87. doi: 10.1007/s10565-011-9208-4. Epub 2012 Jan 19.

PMID:
22258563
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Upcyte® microvascular endothelial cells repopulate decellularized scaffold.

Scheller K, Dally I, Hartmann N, Münst B, Braspenning J, Walles H.

Tissue Eng Part C Methods. 2013 Jan;19(1):57-67. doi: 10.1089/ten.TEC.2011.0723. Epub 2012 Sep 13.

PMID:
22799502
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Feeder-free and serum-free production of hepatocytes, cholangiocytes, and their proliferating progenitors from human pluripotent stem cells: application to liver-specific functional and cytotoxic assays.

Nakamura N, Saeki K, Mitsumoto M, Matsuyama S, Nishio M, Saeki K, Hasegawa M, Miyagawa Y, Ohkita H, Kiyokawa N, Toyoda M, Akutsu H, Umezawa A, Yuo A.

Cell Reprogram. 2012 Apr;14(2):171-85. doi: 10.1089/cell.2011.0064. Epub 2012 Mar 2.

PMID:
22384928
[PubMed - indexed for MEDLINE]
6.

Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies.

Jossé R, Aninat C, Glaise D, Dumont J, Fessard V, Morel F, Poul JM, Guguen-Guillouzo C, Guillouzo A.

Drug Metab Dispos. 2008 Jun;36(6):1111-8. doi: 10.1124/dmd.107.019901. Epub 2008 Mar 17.

PMID:
18347083
[PubMed - indexed for MEDLINE]
Free Article
7.

Expression and induction of CYP1A1/1A2, CYP2A6 and CYP3A4 in primary cultures of human hepatocytes: a 10-year follow-up.

Meunier V, Bourrié M, Julian B, Marti E, Guillou F, Berger Y, Fabre G.

Xenobiotica. 2000 Jun;30(6):589-607.

PMID:
10923861
[PubMed - indexed for MEDLINE]
9.

Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.

Westerink WM, Schoonen WG.

Toxicol In Vitro. 2007 Dec;21(8):1581-91. Epub 2007 Jun 8.

PMID:
17637504
[PubMed - indexed for MEDLINE]
10.

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.

Aninat C, Piton A, Glaise D, Le Charpentier T, Langouët S, Morel F, Guguen-Guillouzo C, Guillouzo A.

Drug Metab Dispos. 2006 Jan;34(1):75-83. Epub 2005 Oct 4.

PMID:
16204462
[PubMed - indexed for MEDLINE]
Free Article
11.

Comparison of basal gene expression and induction of CYP3As in HepG2 and human fetal liver cells.

Maruyama M, Matsunaga T, Harada E, Ohmori S.

Biol Pharm Bull. 2007 Nov;30(11):2091-7.

PMID:
17978482
[PubMed - indexed for MEDLINE]
Free Article
12.

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.

Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, Guguen-Guillouzo C.

Chem Biol Interact. 2007 May 20;168(1):66-73. Epub 2006 Dec 16. Review.

PMID:
17241619
[PubMed - indexed for MEDLINE]
13.

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells.

Anthérieu S, Chesné C, Li R, Camus S, Lahoz A, Picazo L, Turpeinen M, Tolonen A, Uusitalo J, Guguen-Guillouzo C, Guillouzo A.

Drug Metab Dispos. 2010 Mar;38(3):516-25. doi: 10.1124/dmd.109.030197. Epub 2009 Dec 17.

PMID:
20019244
[PubMed - indexed for MEDLINE]
Free Article
14.

Optimization of upcyte® human hepatocytes for the in vitro micronucleus assay.

Nörenberg A, Heinz S, Scheller K, Hewitt NJ, Braspenning J, Ott M.

Mutat Res. 2013 Dec 12;758(1-2):69-79. doi: 10.1016/j.mrgentox.2013.09.008. Epub 2013 Oct 16.

PMID:
24140631
[PubMed - indexed for MEDLINE]
15.

Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET).

Das PC, Cao Y, Rose RL, Cherrington N, Hodgson E.

Drug Metabol Drug Interact. 2008;23(3-4):237-60.

PMID:
19326769
[PubMed - indexed for MEDLINE]
16.

Cytochrome P450 expression profile of the PICM-19H pig liver cell line: potential application to rapid liver toxicity assays.

Willard RR, Shappell NW, Meekin JH, Talbot NC, Caperna TJ.

In Vitro Cell Dev Biol Anim. 2010 Jan;46(1):11-9. doi: 10.1007/s11626-009-9244-z.

PMID:
19915937
[PubMed - indexed for MEDLINE]
17.

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

Ripp SL, Mills JB, Fahmi OA, Trevena KA, Liras JL, Maurer TS, de Morais SM.

Drug Metab Dispos. 2006 Oct;34(10):1742-8. Epub 2006 Jul 12.

PMID:
16837568
[PubMed - indexed for MEDLINE]
Free Article
18.

In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes.

Jackson JP, Kabirov KK, Kapetanovic IM, Lyubimov A.

Chem Biol Interact. 2009 May 15;179(2-3):263-72. doi: 10.1016/j.cbi.2008.12.005. Epub 2008 Dec 16.

PMID:
19135037
[PubMed - indexed for MEDLINE]
19.

Fipronil induces CYP isoforms and cytotoxicity in human hepatocytes.

Das PC, Cao Y, Cherrington N, Hodgson E, Rose RL.

Chem Biol Interact. 2006 Dec 15;164(3):200-14. Epub 2006 Oct 6.

PMID:
17084830
[PubMed - indexed for MEDLINE]
20.

Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers.

Sa-ngiamsuntorn K, Wongkajornsilp A, Kasetsinsombat K, Duangsa-ard S, Nuntakarn L, Borwornpinyo S, Akarasereenont P, Limsrichamrern S, Hongeng S.

BMC Biotechnol. 2011 Sep 30;11:89. doi: 10.1186/1472-6750-11-89.

PMID:
21961524
[PubMed - indexed for MEDLINE]
Free PMC Article

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