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Related Citations for PubMed (Select 22522618)


Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.

Kronenberg D, Knight RR, Estorninho M, Ellis RJ, Kester MG, de Ru A, Eichmann M, Huang GC, Powrie J, Dayan CM, Skowera A, van Veelen PA, Peakman M.

Diabetes. 2012 Jul;61(7):1752-9. doi: 10.2337/db11-1520. Epub 2012 Apr 20.


CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M.

J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. Erratum in: J Clin Invest. 2009 Sep;119(9):2844. Unger, Wendy [corrected to Unger, Wendy W].


Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.

Unger WW, Velthuis J, Abreu JR, Laban S, Quinten E, Kester MG, Reker-Hadrup S, Bakker AH, Duinkerken G, Mulder A, Franken KL, Hilbrands R, Keymeulen B, Peakman M, Ossendorp F, Drijfhout JW, Schumacher TN, Roep BO.

J Autoimmun. 2011 Nov;37(3):151-9. doi: 10.1016/j.jaut.2011.05.012. Epub 2011 Jun 1.


CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.

Abreu JR, Martina S, Verrijn Stuart AA, Fillié YE, Franken KL, Drijfhout JW, Roep BO.

Clin Exp Immunol. 2012 Oct;170(1):57-65. doi: 10.1111/j.1365-2249.2012.04635.x.


Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery.

Baker C, Petrich de Marquesini LG, Bishop AJ, Hedges AJ, Dayan CM, Wong FS.

J Clin Immunol. 2008 Jul;28(4):350-60. doi: 10.1007/s10875-008-9177-4. Epub 2008 Feb 29.


Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.

Knight RR, Kronenberg D, Zhao M, Huang GC, Eichmann M, Bulek A, Wooldridge L, Cole DK, Sewell AK, Peakman M, Skowera A.

Diabetes. 2013 Jan;62(1):205-13. doi: 10.2337/db12-0315. Epub 2012 Aug 30.


Immunology of Diabetes Society T-Cell Workshop: HLA class I tetramer-directed epitope validation initiative T-Cell Workshop Report-HLA Class I Tetramer Validation Initiative.

Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):720-6. doi: 10.1002/dmrr.1243.


Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes.

Toma A, Laïka T, Haddouk S, Luce S, Briand JP, Camoin L, Connan F, Lambert M, Caillat-Zucman S, Carel JC, Muller S, Choppin J, Lemonnier F, Boitard C.

Diabetes. 2009 Feb;58(2):394-402. doi: 10.2337/db08-0599. Epub 2008 Nov 14.


T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin.

Congia M, Patel S, Cope AP, De Virgiliis S, Sønderstrup G.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3833-8.


Identification of HLA-A24-restricted CD8(+) cytotoxic T-cell epitopes derived from mammaglobin-A, a human breast cancer-associated antigen.

Tiriveedhi V, Sarma NJ, Subramanian V, Fleming TP, Gillanders WE, Mohanakumar T.

Hum Immunol. 2012 Jan;73(1):11-6. doi: 10.1016/j.humimm.2011.10.017. Epub 2011 Oct 23.


The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment.

Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R.

Diabetes. 2008 May;57(5):1312-20. doi: 10.2337/db07-1594. Epub 2008 Feb 27.


Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.

Unger WW, Pearson T, Abreu JR, Laban S, van der Slik AR, der Kracht SM, Kester MG, Serreze DV, Shultz LD, Griffioen M, Drijfhout JW, Greiner DL, Roep BO.

PLoS One. 2012;7(11):e49213. doi: 10.1371/journal.pone.0049213. Epub 2012 Nov 14.


Novel epitope begets a novel pathway in type 1 diabetes progression.

Frelinger JA.

J Clin Invest. 2008 Oct;118(10):3268-71. doi: 10.1172/JCI37125.


CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope.

Yang J, Danke N, Roti M, Huston L, Greenbaum C, Pihoker C, James E, Kwok WW.

J Autoimmun. 2008 Aug;31(1):30-41. doi: 10.1016/j.jaut.2008.02.001. Epub 2008 Apr 2.


Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.

Ouyang Q, Standifer NE, Qin H, Gottlieb P, Verchere CB, Nepom GT, Tan R, Panagiotopoulos C.

Diabetes. 2006 Nov;55(11):3068-74.


Weak binder for MHC molecule is a potent Mycobacterium tuberculosis-specific CTL epitope in the context of HLA-A24 allele.

Wang Y, Sun M, He M, Cui H, Zhang J, Shi L, Wang W, Xu W, Gao B, Ding J.

Microb Pathog. 2012 Sep;53(3-4):162-7. doi: 10.1016/j.micpath.2012.07.002. Epub 2012 Jul 20. Erratum in: Microb Pathog. 2013 Mar;56:60.


Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.

Togun RA, Resetkova E, Kawai K, Enomoto T, Volpé R.

Clin Immunol Immunopathol. 1997 Mar;82(3):243-9.


T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives.

Mallone R, Brezar V, Boitard C.

Clin Dev Immunol. 2011;2011:513210. doi: 10.1155/2011/513210. Epub 2011 Jul 19. Review.


Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.

Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C.

Diabetes. 2011 Dec;60(12):3289-99. doi: 10.2337/db11-0270. Epub 2011 Oct 13.

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