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The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.

Schank JR, Goldstein AL, Rowe KE, King CE, Marusich JA, Wiley JL, Carroll FI, Thorsell A, Heilig M.

Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.


The role of kappa opioid receptors in stress-induced reinstatement of alcohol seeking in rats.

Funk D, Coen K, Lê AD.

Brain Behav. 2014 May;4(3):356-67. doi: 10.1002/brb3.222. Epub 2014 Feb 17.


Effect of the selective kappa-opioid receptor antagonist JDTic on nicotine antinociception, reward, and withdrawal in the mouse.

Jackson KJ, Carroll FI, Negus SS, Damaj MI.

Psychopharmacology (Berl). 2010 Jun;210(2):285-94. doi: 10.1007/s00213-010-1803-1. Epub 2010 Mar 16.


The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats.

Deehan GA Jr, McKinzie DL, Carroll FI, McBride WJ, Rodd ZA.

Pharmacol Biochem Behav. 2012 Jun;101(4):581-7. doi: 10.1016/j.pbb.2012.03.006. Epub 2012 Mar 10.


The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors.

Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.

Biol Psychiatry. 2014 May 15;75(10):774-82. doi: 10.1016/j.biopsych.2013.03.014. Epub 2013 Apr 21.


Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.

Gillett K, Harshberger E, Valdez GR.

Alcohol. 2013 Aug;47(5):359-65. doi: 10.1016/j.alcohol.2013.05.001. Epub 2013 May 31.


Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors.

Berger AL, Williams AM, McGinnis MM, Walker BM.

Neuropsychopharmacology. 2013 Mar;38(4):647-54. doi: 10.1038/npp.2012.229. Epub 2012 Nov 6.


Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429.

Schank JR, Pickens CL, Rowe KE, Cheng K, Thorsell A, Rice KC, Shaham Y, Heilig M.

Psychopharmacology (Berl). 2011 Nov;218(1):111-9. doi: 10.1007/s00213-011-2201-z. Epub 2011 Feb 22.


Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats.

Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA Jr.

Biol Psychiatry. 2011 Sep 1;70(5):425-33. doi: 10.1016/j.biopsych.2011.03.017. Epub 2011 Apr 30.


Role of the kappa-opioid receptor system in stress-induced reinstatement of nicotine seeking in rats.

Grella SL, Funk D, Coen K, Li Z, Lê AD.

Behav Brain Res. 2014 May 15;265:188-97. doi: 10.1016/j.bbr.2014.02.029. Epub 2014 Feb 28.


Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.

Walker BM, Zorrilla EP, Koob GF.

Addict Biol. 2011 Jan;16(1):116-9. doi: 10.1111/j.1369-1600.2010.00226.x.


Pharmacological properties of JDTic: a novel kappa-opioid receptor antagonist.

Carroll I, Thomas JB, Dykstra LA, Granger AL, Allen RM, Howard JL, Pollard GT, Aceto MD, Harris LS.

Eur J Pharmacol. 2004 Oct 6;501(1-3):111-9.


κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal.

Valdez GR, Harshberger E.

Pharmacol Biochem Behav. 2012 Jul;102(1):44-7. doi: 10.1016/j.pbb.2012.03.019. Epub 2012 Apr 2.


Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence.

Walker BM, Koob GF.

Neuropsychopharmacology. 2008 Feb;33(3):643-52. Epub 2007 May 2.


Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats.

Walker BM, Kissler JL.

Neuropsychopharmacology. 2013 Oct;38(11):2278-85. doi: 10.1038/npp.2013.129. Epub 2013 May 21.


Corticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the κ-opioid receptor antagonist JDTic.

Van't Veer A, Yano JM, Carroll FI, Cohen BM, Carlezon WA Jr.

Neuropsychopharmacology. 2012 Dec;37(13):2809-16. doi: 10.1038/npp.2012.151. Epub 2012 Sep 5.


Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats.

Economidou D, Mattioli L, Cifani C, Perfumi M, Massi M, Cuomo V, Trabace L, Ciccocioppo R.

Psychopharmacology (Berl). 2006 Jan;183(4):394-403. Epub 2005 Oct 29.

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