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Results: 1 to 20 of 118

1.

Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.

Bauer J, Kuehnl S, Rollinger JM, Scherer O, Northoff H, Stuppner H, Werz O, Koeberle A.

J Pharmacol Exp Ther. 2012 Jul;342(1):169-76. doi: 10.1124/jpet.112.193847. Epub 2012 Apr 16.

PMID:
22511203
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1.

Koeberle A, Pollastro F, Northoff H, Werz O.

Br J Pharmacol. 2009 Mar;156(6):952-61. doi: 10.1111/j.1476-5381.2009.00070.x.

PMID:
19298395
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.

J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24.

PMID:
19934399
[PubMed - indexed for MEDLINE]
Free Article
4.

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.

Koeberle A, Northoff H, Werz O.

Mol Cancer Ther. 2009 Aug;8(8):2348-55. doi: 10.1158/1535-7163.MCT-09-0290. Epub 2009 Aug 11.

PMID:
19671757
[PubMed - indexed for MEDLINE]
Free Article
5.

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

Koeberle A, Siemoneit U, Bühring U, Northoff H, Laufer S, Albrecht W, Werz O.

J Pharmacol Exp Ther. 2008 Sep;326(3):975-82. doi: 10.1124/jpet.108.139444. Epub 2008 Jun 11.

PMID:
18550688
[PubMed - indexed for MEDLINE]
Free Article
6.

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1.

Koeberle A, Bauer J, Verhoff M, Hoffmann M, Northoff H, Werz O.

Biochem Biophys Res Commun. 2009 Oct 16;388(2):350-4. doi: 10.1016/j.bbrc.2009.08.005. Epub 2009 Aug 6.

PMID:
19665000
[PubMed - indexed for MEDLINE]
7.

Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.

Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML, Patrignani P.

Biochem Pharmacol. 2010 Apr 1;79(7):974-81. doi: 10.1016/j.bcp.2009.11.011. Epub 2009 Nov 27.

PMID:
19925781
[PubMed - indexed for MEDLINE]
8.

Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis.

Horiuchi K, Shiota S, Kuroda T, Hatano T, Yoshida T, Tsuchiya T.

Biol Pharm Bull. 2007 Feb;30(2):287-90.

PMID:
17268067
[PubMed - indexed for MEDLINE]
Free Article
9.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.

Biochem Pharmacol. 2010 May 15;79(10):1445-54. doi: 10.1016/j.bcp.2010.01.003. Epub 2010 Jan 11.

PMID:
20067770
[PubMed - indexed for MEDLINE]
10.

Carnosic acid, a new class of lipid absorption inhibitor from sage.

Ninomiya K, Matsuda H, Shimoda H, Nishida N, Kasajima N, Yoshino T, Morikawa T, Yoshikawa M.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1943-6.

PMID:
15050633
[PubMed - indexed for MEDLINE]
11.

Hyperforin, an Anti-Inflammatory Constituent from St. John's Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo.

Koeberle A, Rossi A, Bauer J, Dehm F, Verotta L, Northoff H, Sautebin L, Werz O.

Front Pharmacol. 2011 Feb 18;2:7. doi: 10.3389/fphar.2011.00007. eCollection 2011.

PMID:
21687502
[PubMed]
Free PMC Article
12.

Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves.

Kuo CF, Su JD, Chiu CH, Peng CC, Chang CH, Sung TY, Huang SH, Lee WC, Chyau CC.

J Agric Food Chem. 2011 Apr 27;59(8):3674-85. doi: 10.1021/jf104837w. Epub 2011 Mar 4.

PMID:
21375325
[PubMed - indexed for MEDLINE]
13.

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.

Koeberle A, Northoff H, Werz O.

Biochem Pharmacol. 2009 May 1;77(9):1513-21. doi: 10.1016/j.bcp.2009.02.005. Epub 2009 Feb 21.

PMID:
19426689
[PubMed - indexed for MEDLINE]
14.

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.

Schaible AM, Traber H, Temml V, Noha SM, Filosa R, Peduto A, Weinigel C, Barz D, Schuster D, Werz O.

Biochem Pharmacol. 2013 Aug 15;86(4):476-86. doi: 10.1016/j.bcp.2013.04.015. Epub 2013 Apr 24.

PMID:
23623753
[PubMed - indexed for MEDLINE]
15.

Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice.

Rodrigues MR, Kanazawa LK, das Neves TL, da Silva CF, Horst H, Pizzolatti MG, Santos AR, Baggio CH, Werner MF.

J Ethnopharmacol. 2012 Jan 31;139(2):519-26. doi: 10.1016/j.jep.2011.11.042. Epub 2011 Dec 2.

PMID:
22154965
[PubMed - indexed for MEDLINE]
16.

Antimicrobial activity of Rosmarinus officinalis against oral pathogens: relevance of carnosic acid and carnosol.

Bernardes WA, Lucarini R, Tozatti MG, Souza MG, Silva ML, Filho AA, Martins CH, Crotti AE, Pauletti PM, Groppo M, Cunha WR.

Chem Biodivers. 2010 Jul;7(7):1835-40. doi: 10.1002/cbdv.200900301.

PMID:
20658673
[PubMed - indexed for MEDLINE]
17.

Antiplatelet activity of carnosic acid, a phenolic diterpene from Rosmarinus officinalis.

Lee JJ, Jin YR, Lee JH, Yu JY, Han XH, Oh KW, Hong JT, Kim TJ, Yun YP.

Planta Med. 2007 Feb;73(2):121-7.

PMID:
17410649
[PubMed - indexed for MEDLINE]
18.

Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1.

Guay J, Bateman K, Gordon R, Mancini J, Riendeau D.

J Biol Chem. 2004 Jun 4;279(23):24866-72. Epub 2004 Mar 24.

PMID:
15044444
[PubMed - indexed for MEDLINE]
Free Article
19.

Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.

López-Jiménez A, García-Caballero M, Medina MÁ, Quesada AR.

Eur J Nutr. 2013 Feb;52(1):85-95. doi: 10.1007/s00394-011-0289-x. Epub 2011 Dec 16.

PMID:
22173778
[PubMed - indexed for MEDLINE]
20.

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells.

Hanaka H, Pawelzik SC, Johnsen JI, Rakonjac M, Terawaki K, Rasmuson A, Sveinbjörnsson B, Schumacher MC, Hamberg M, Samuelsson B, Jakobsson PJ, Kogner P, Rådmark O.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18757-62. doi: 10.1073/pnas.0910218106. Epub 2009 Oct 21.

PMID:
19846775
[PubMed - indexed for MEDLINE]
Free PMC Article

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