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Results: 1 to 20 of 131

1.

Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.

Levy D, Davidovich A, Zirkin S, Frug Y, Cohen AM, Shalom S, Don J.

PLoS One. 2012;7(4):e34736. doi: 10.1371/journal.pone.0034736. Epub 2012 Apr 10.

PMID:
22506047
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The PIM-2 kinase is an essential component of the ultraviolet damage response that acts upstream to E2F-1 and ATM.

Zirkin S, Davidovich A, Don J.

J Biol Chem. 2013 Jul 26;288(30):21770-83. doi: 10.1074/jbc.M113.458851. Epub 2013 Jun 11.

PMID:
23760264
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation.

Koida N, Ozaki T, Yamamoto H, Ono S, Koda T, Ando K, Okoshi R, Kamijo T, Omura K, Nakagawara A.

J Biol Chem. 2008 Mar 28;283(13):8555-63. doi: 10.1074/jbc.M710608200. Epub 2008 Jan 3.

PMID:
18174154
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells.

Yun HJ, Hyun SK, Park JH, Kim BW, Kwon HJ.

Mol Cell Biochem. 2012 Apr;363(1-2):281-9. doi: 10.1007/s11010-011-1180-z. Epub 2011 Dec 11.

PMID:
22160829
[PubMed - indexed for MEDLINE]
5.

Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.

Ionov Y, Le X, Tunquist BJ, Sweetenham J, Sachs T, Ryder J, Johnson T, Lilly MB, Kraft AS.

Anticancer Res. 2003 Jan-Feb;23(1A):167-78.

PMID:
12680209
[PubMed - indexed for MEDLINE]
6.

Adhesion-regulated G1 cell cycle arrest in epithelial cells requires the downregulation of c-Myc.

Benaud CM, Dickson RB.

Oncogene. 2001 Jul 27;20(33):4554-67.

PMID:
11494151
[PubMed - indexed for MEDLINE]
Free Article
7.

Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function.

Foster JS, Henley DC, Bukovsky A, Seth P, Wimalasena J.

Mol Cell Biol. 2001 Feb;21(3):794-810.

PMID:
11154267
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.

Yang Q, Chen LS, Neelapu SS, Miranda RN, Medeiros LJ, Gandhi V.

Blood. 2012 Oct 25;120(17):3491-500. doi: 10.1182/blood-2012-02-412643. Epub 2012 Sep 6.

PMID:
22955922
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Molecular mechanisms underlying interferon-alpha-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins.

Sangfelt O, Erickson S, Castro J, Heiden T, Gustafsson A, Einhorn S, Grandér D.

Oncogene. 1999 May 6;18(18):2798-810.

PMID:
10362250
[PubMed - indexed for MEDLINE]
Free Article
10.

Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins.

de Carné Trécesson S, Guillemin Y, Bélanger A, Bernard AC, Preisser L, Ravon E, Gamelin E, Juin P, Barré B, Coqueret O.

J Biol Chem. 2011 Apr 15;286(15):12825-38. doi: 10.1074/jbc.M110.186437. Epub 2011 Feb 3.

PMID:
21292770
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.

Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M.

J Biol Chem. 2003 Nov 14;278(46):45358-67. Epub 2003 Sep 3.

PMID:
12954615
[PubMed - indexed for MEDLINE]
Free Article
12.

Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 up-regulation and PLK1 down-regulation.

Ismail IA, Kang KS, Lee HA, Kim JW, Sohn YK.

Eur J Pharmacol. 2007 Dec 1;575(1-3):12-20. Epub 2007 Jul 28.

PMID:
17706963
[PubMed - indexed for MEDLINE]
13.

E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells.

Li Y, Shao J, Shen K, Xu Y, Liu J, Qian X.

J Cell Biochem. 2012 Oct;113(10):3165-77. doi: 10.1002/jcb.24194.

PMID:
22593008
[PubMed - indexed for MEDLINE]
15.

IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils.

Stout BA, Bates ME, Liu LY, Farrington NN, Bertics PJ.

J Immunol. 2004 Nov 15;173(10):6409-17.

PMID:
15528381
[PubMed - indexed for MEDLINE]
Free Article
16.

Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1).

Kreis NN, Sommer K, Sanhaji M, Krämer A, Matthess Y, Kaufmann M, Strebhardt K, Yuan J.

Cell Cycle. 2009 Feb 1;8(3):460-72. Epub 2009 Feb 18.

PMID:
19177004
[PubMed - indexed for MEDLINE]
Free Article
17.

Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.

Wang Z, Zhang Y, Gu JJ, Davitt C, Reeves R, Magnuson NS.

Int J Biochem Cell Biol. 2010 Jun;42(6):1030-8. doi: 10.1016/j.biocel.2010.03.012. Epub 2010 Mar 20.

PMID:
20307683
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.

Atienza C Jr, Elliott MJ, Dong YB, Yang HL, Stilwell A, Liu TJ, McMasters KM.

Int J Mol Med. 2000 Jul;6(1):55-63.

PMID:
10851267
[PubMed - indexed for MEDLINE]
19.

Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin.

Momeny M, Zakidizaji M, Ghasemi R, Dehpour AR, Rahimi-Balaei M, Abdolazimi Y, Ghavamzadeh A, Alimoghaddam K, Ghaffari SH.

Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.

PMID:
19763917
[PubMed - indexed for MEDLINE]
20.

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis.

Popivanova BK, Li YY, Zheng H, Omura K, Fujii C, Tsuneyama K, Mukaida N.

Cancer Sci. 2007 Mar;98(3):321-8.

PMID:
17270021
[PubMed - indexed for MEDLINE]

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