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Results: 1 to 20 of 96

1.

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

Michalon A, Sidorov M, Ballard TM, Ozmen L, Spooren W, Wettstein JG, Jaeschke G, Bear MF, Lindemann L.

Neuron. 2012 Apr 12;74(1):49-56. doi: 10.1016/j.neuron.2012.03.009.

PMID:
22500629
[PubMed - indexed for MEDLINE]
Free Article
2.

Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice.

Michalon A, Bruns A, Risterucci C, Honer M, Ballard TM, Ozmen L, Jaeschke G, Wettstein JG, von Kienlin M, Künnecke B, Lindemann L.

Biol Psychiatry. 2014 Feb 1;75(3):189-97. doi: 10.1016/j.biopsych.2013.05.038. Epub 2013 Jul 30.

PMID:
23910948
[PubMed - indexed for MEDLINE]
3.

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

Nosyreva ED, Huber KM.

J Neurophysiol. 2006 May;95(5):3291-5. Epub 2006 Feb 1.

PMID:
16452252
[PubMed - indexed for MEDLINE]
Free Article
4.

Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome.

Su T, Fan HX, Jiang T, Sun WW, Den WY, Gao MM, Chen SQ, Zhao QH, Yi YH.

Psychopharmacology (Berl). 2011 May;215(2):291-300. doi: 10.1007/s00213-010-2130-2. Epub 2010 Dec 23.

PMID:
21181121
[PubMed - indexed for MEDLINE]
5.

Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, Postma FR, Brynczka C, Rush R, Thomas A, Paylor R, Warren ST, Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM.

Sci Transl Med. 2012 Sep 19;4(152):152ra128.

PMID:
22993295
[PubMed - indexed for MEDLINE]
Free Article
6.

Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse.

Meredith RM, de Jong R, Mansvelder HD.

Neurobiol Dis. 2011 Jan;41(1):104-10. doi: 10.1016/j.nbd.2010.08.026. Epub 2010 Sep 15.

PMID:
20817093
[PubMed - indexed for MEDLINE]
7.

Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.

Osterweil EK, Krueger DD, Reinhold K, Bear MF.

J Neurosci. 2010 Nov 17;30(46):15616-27. doi: 10.1523/JNEUROSCI.3888-10.2010.

PMID:
21084617
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

Yan QJ, Rammal M, Tranfaglia M, Bauchwitz RP.

Neuropharmacology. 2005 Dec;49(7):1053-66. Epub 2005 Jul 27.

PMID:
16054174
[PubMed - indexed for MEDLINE]
9.

The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice.

Vinueza Veloz MF, Buijsen RA, Willemsen R, Cupido A, Bosman LW, Koekkoek SK, Potters JW, Oostra BA, De Zeeuw CI.

Genes Brain Behav. 2012 Apr;11(3):325-31. doi: 10.1111/j.1601-183X.2011.00763.x. Epub 2012 Jan 19.

PMID:
22257369
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A reduced number of metabotropic glutamate subtype 5 receptors are associated with constitutive homer proteins in a mouse model of fragile X syndrome.

Giuffrida R, Musumeci S, D'Antoni S, Bonaccorso CM, Giuffrida-Stella AM, Oostra BA, Catania MV.

J Neurosci. 2005 Sep 28;25(39):8908-16.

PMID:
16192381
[PubMed - indexed for MEDLINE]
Free Article
11.

Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome.

Suvrathan A, Hoeffer CA, Wong H, Klann E, Chattarji S.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11591-6. doi: 10.1073/pnas.1002262107. Epub 2010 Jun 7.

PMID:
20534533
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Fragile X syndrome therapeutics S(C)TEP through the developmental window.

Bhattacharya A, Klann E.

Neuron. 2012 Apr 12;74(1):1-3. doi: 10.1016/j.neuron.2012.03.014.

PMID:
22500622
[PubMed - indexed for MEDLINE]
Free Article
13.

Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

Westmark CJ, Westmark PR, O'Riordan KJ, Ray BC, Hervey CM, Salamat MS, Abozeid SH, Stein KM, Stodola LA, Tranfaglia M, Burger C, Berry-Kravis EM, Malter JS.

PLoS One. 2011;6(10):e26549. doi: 10.1371/journal.pone.0026549. Epub 2011 Oct 26.

PMID:
22046307
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome.

Liu ZH, Huang T, Smith CB.

Neurobiol Dis. 2012 Mar;45(3):1145-52. doi: 10.1016/j.nbd.2011.12.037. Epub 2011 Dec 29.

PMID:
22227453
[PubMed - indexed for MEDLINE]
15.

Biomedical research. A fix for fragile X syndrome?

Miller G.

Science. 2006 Apr 28;312(5773):521. No abstract available.

PMID:
16645065
[PubMed - indexed for MEDLINE]
16.

Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome.

Xu ZH, Yang Q, Feng B, Liu SB, Zhang N, Xing JH, Li XQ, Wu YM, Gao GD, Zhao MG.

Mol Neurodegener. 2012 May 28;7:24. doi: 10.1186/1750-1326-7-24.

PMID:
22640474
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor.

Lindemann L, Jaeschke G, Michalon A, Vieira E, Honer M, Spooren W, Porter R, Hartung T, Kolczewski S, Büttelmann B, Flament C, Diener C, Fischer C, Gatti S, Prinssen EP, Parrott N, Hoffmann G, Wettstein JG.

J Pharmacol Exp Ther. 2011 Nov;339(2):474-86. doi: 10.1124/jpet.111.185660. Epub 2011 Aug 17.

PMID:
21849627
[PubMed - indexed for MEDLINE]
Free Article
18.

Fragile X syndrome -- from genes to cognition.

Schneider A, Hagerman RJ, Hessl D.

Dev Disabil Res Rev. 2009;15(4):333-42. doi: 10.1002/ddrr.80.

PMID:
20014363
[PubMed - indexed for MEDLINE]
19.

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse.

Pacey LK, Doss L, Cifelli C, van der Kooy D, Heximer SP, Hampson DR.

Mol Cell Neurosci. 2011 Mar;46(3):563-72. doi: 10.1016/j.mcn.2010.12.005. Epub 2011 Jan 6.

PMID:
21215802
[PubMed - indexed for MEDLINE]
20.

Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice.

Dansie LE, Phommahaxay K, Okusanya AG, Uwadia J, Huang M, Rotschafer SE, Razak KA, Ethell DW, Ethell IM.

Neuroscience. 2013 Aug 29;246:186-98. doi: 10.1016/j.neuroscience.2013.04.058. Epub 2013 May 7.

PMID:
23660195
[PubMed - indexed for MEDLINE]
Free PMC Article

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