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Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling.

Willoughby D, Everett KL, Halls ML, Pacheco J, Skroblin P, Vaca L, Klussmann E, Cooper DM.

Sci Signal. 2012 Apr 10;5(219):ra29. doi: 10.1126/scisignal.2002299.


Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8.

Martin AC, Willoughby D, Ciruela A, Ayling LJ, Pagano M, Wachten S, Tengholm A, Cooper DM.

Mol Pharmacol. 2009 Apr;75(4):830-42. doi: 10.1124/mol.108.051748. Epub 2009 Jan 26. Erratum in: Mol Pharmacol. 2009 May;75(5):1248.


An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

Everett KL, Cooper DM.

PLoS One. 2013 Sep 23;8(9):e75942. doi: 10.1371/journal.pone.0075942. eCollection 2013.


Direct demonstration of discrete Ca2+ microdomains associated with different isoforms of adenylyl cyclase.

Willoughby D, Wachten S, Masada N, Cooper DM.

J Cell Sci. 2010 Jan 1;123(Pt 1):107-17. doi: 10.1242/jcs.062067.


Organization of cAMP signalling microdomains for optimal regulation by Ca2+ entry.

Willoughby D.

Biochem Soc Trans. 2012 Feb;40(1):246-50. doi: 10.1042/BST20110613. Review.


AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems.

Willoughby D, Masada N, Wachten S, Pagano M, Halls ML, Everett KL, Ciruela A, Cooper DM.

J Biol Chem. 2010 Jun 25;285(26):20328-42. doi: 10.1074/jbc.M110.120725. Epub 2010 Apr 21.


Termination and activation of store-operated cyclic AMP production.

Maiellaro I, Lefkimmiatis K, Moyer MP, Curci S, Hofer AM.

J Cell Mol Med. 2012 Nov;16(11):2715-25. doi: 10.1111/j.1582-4934.2012.01592.x.


Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP.

Willoughby D, Cooper DM.

J Cell Sci. 2006 Mar 1;119(Pt 5):828-36. Epub 2006 Feb 14.


TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases.

Willoughby D, Ong HL, De Souza LB, Wachten S, Ambudkar IS, Cooper DM.

Biochem J. 2014 Nov 15;464(1):73-84. doi: 10.1042/BJ20140766.


Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels.

Jardin I, Lopez JJ, Salido GM, Rosado JA.

J Biol Chem. 2008 Sep 12;283(37):25296-304. doi: 10.1074/jbc.M802904200. Epub 2008 Jul 20.


A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM.

Mol Pharmacol. 2006 Feb;69(2):608-17. Epub 2005 Oct 28.


cAMP-PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3-Orai1 complex.

Clarysse L, Guéguinou M, Potier-Cartereau M, Vandecasteele G, Bougnoux P, Chevalier S, Chantôme A, Vandier C.

Pflugers Arch. 2014 Oct;466(10):1921-32. doi: 10.1007/s00424-013-1435-5. Epub 2014 Jan 24.


Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.

Masada N, Ciruela A, Macdougall DA, Cooper DM.

J Biol Chem. 2009 Feb 13;284(7):4451-63. doi: 10.1074/jbc.M807359200. Epub 2008 Nov 24. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122.


Regulation by Ca2+-signaling pathways of adenylyl cyclases.

Halls ML, Cooper DM.

Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004143. doi: 10.1101/cshperspect.a004143. Review.


The type 8 adenylyl cyclase is critical for Ca2+ stimulation of cAMP accumulation in mouse parotid acini.

Watson EL, Jacobson KL, Singh JC, Idzerda R, Ott SM, DiJulio DH, Wong ST, Storm DR.

J Biol Chem. 2000 May 12;275(19):14691-9.


Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.

Smith KE, Gu C, Fagan KA, Hu B, Cooper DM.

J Biol Chem. 2002 Feb 22;277(8):6025-31. Epub 2001 Dec 13.


Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.

von Hayn K, Werthmann RC, Nikolaev VO, Hommers LG, Lohse MJ, Bünemann M.

Am J Physiol Cell Physiol. 2010 Feb;298(2):C324-32. doi: 10.1152/ajpcell.00197.2009. Epub 2009 Nov 4.


The role of Ca²⁺-stimulated adenylyl cyclases in bidirectional synaptic plasticity and brain function.

Wang H, Zhang M.

Rev Neurosci. 2012;23(1):67-78. doi: 10.1515/revneuro-2011-0063. Review.


A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

Willoughby D, Halls ML, Everett KL, Ciruela A, Skroblin P, Klussmann E, Cooper DM.

J Cell Sci. 2012 Dec 1;125(Pt 23):5850-9. doi: 10.1242/jcs.111427. Epub 2012 Sep 12.


Molecular and cellular requirements for the regulation of adenylate cyclases by calcium.

Cooper DM.

Biochem Soc Trans. 2003 Oct;31(Pt 5):912-5. Review.

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