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Results: 1 to 20 of 108

1.

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.

Senejani AG, Dalal S, Liu Y, Nottoli TP, McGrath JM, Clairmont CS, Sweasy JB.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6632-7. doi: 10.1073/pnas.1200800109. Epub 2012 Apr 9.

PMID:
22493258
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Mammalian DNA beta-polymerase in base excision repair of alkylation damage.

Sobol RW, Wilson SH.

Prog Nucleic Acid Res Mol Biol. 2001;68:57-74. Review.

PMID:
11554313
[PubMed - indexed for MEDLINE]
3.

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens.

Cabelof DC, Guo Z, Raffoul JJ, Sobol RW, Wilson SH, Richardson A, Heydari AR.

Cancer Res. 2003 Sep 15;63(18):5799-807.

PMID:
14522902
[PubMed - indexed for MEDLINE]
Free Article
4.

Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo.

Cabelof DC, Raffoul JJ, Yanamadala S, Guo Z, Heydari AR.

Carcinogenesis. 2002 Sep;23(9):1419-25.

PMID:
12189182
[PubMed - indexed for MEDLINE]
Free Article
5.

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation.

Nemec AA, Donigan KA, Murphy DL, Jaeger J, Sweasy JB.

J Biol Chem. 2012 Jul 6;287(28):23840-9. doi: 10.1074/jbc.M112.362111. Epub 2012 May 9.

PMID:
22573322
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts.

Podlutsky AJ, Dianova II, Wilson SH, Bohr VA, Dianov GL.

Biochemistry. 2001 Jan 23;40(3):809-13.

PMID:
11170398
[PubMed - indexed for MEDLINE]
7.

Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

Ochs K, Sobol RW, Wilson SH, Kaina B.

Cancer Res. 1999 Apr 1;59(7):1544-51.

PMID:
10197627
[PubMed - indexed for MEDLINE]
Free Article
8.

Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress.

Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Ladapo J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5. Epub 2002 Apr 30.

PMID:
11983862
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

Guo Z, Zheng L, Dai H, Zhou M, Xu H, Shen B.

Nucleic Acids Res. 2009 Jun;37(10):3431-41. doi: 10.1093/nar/gkp201. Epub 2009 Mar 31.

PMID:
19336415
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

Yamtich J, Nemec AA, Keh A, Sweasy JB.

PLoS Genet. 2012;8(11):e1003052. doi: 10.1371/journal.pgen.1003052. Epub 2012 Nov 8.

PMID:
23144635
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.

Lang T, Dalal S, Chikova A, DiMaio D, Sweasy JB.

Mol Cell Biol. 2007 Aug;27(15):5587-96. Epub 2007 May 25.

PMID:
17526740
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Up-regulation of base excision repair correlates with enhanced protection against a DNA damaging agent in mouse cell lines.

Chen KH, Yakes FM, Srivastava DK, Singhal RK, Sobol RW, Horton JK, Van Houten B, Wilson SH.

Nucleic Acids Res. 1998 Apr 15;26(8):2001-7.

PMID:
9518496
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide.

Fortini P, Pascucci B, Belisario F, Dogliotti E.

Nucleic Acids Res. 2000 Aug 15;28(16):3040-6.

PMID:
10931918
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

DNA polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts.

Braithwaite EK, Kedar PS, Stumpo DJ, Bertocci B, Freedman JH, Samson LD, Wilson SH.

PLoS One. 2010 Aug 18;5(8):e12229. doi: 10.1371/journal.pone.0012229.

PMID:
20805875
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.

Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA, Wilson SH.

Cell Res. 2008 Jan;18(1):48-63. doi: 10.1038/cr.2008.7. Review.

PMID:
18166976
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair.

Horton JK, Prasad R, Hou E, Wilson SH.

J Biol Chem. 2000 Jan 21;275(3):2211-8.

PMID:
10636928
[PubMed - indexed for MEDLINE]
Free Article
17.

The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells.

Clairmont CA, Narayanan L, Sun KW, Glazer PM, Sweasy JB.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9580-5.

PMID:
10449735
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency.

Cabelof DC, Raffoul JJ, Nakamura J, Kapoor D, Abdalla H, Heydari AR.

J Biol Chem. 2004 Aug 27;279(35):36504-13. Epub 2004 Jun 24.

PMID:
15218023
[PubMed - indexed for MEDLINE]
Free Article
19.

'Knock down' of DNA polymerase beta by RNA interference: recapitulation of null phenotype.

Polosina YY, Rosenquist TA, Grollman AP, Miller H.

DNA Repair (Amst). 2004 Nov 2;3(11):1469-74.

PMID:
15380102
[PubMed - indexed for MEDLINE]
20.

The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells.

Pascucci B, Russo MT, Crescenzi M, Bignami M, Dogliotti E.

Nucleic Acids Res. 2005 Jan 12;33(1):280-8. Print 2005.

PMID:
15647510
[PubMed - indexed for MEDLINE]
Free PMC Article

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