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Items: 1 to 20 of 96


Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch.

Marquez RT, Xu L.

Am J Cancer Res. 2012;2(2):214-21. Epub 2012 Feb 15.


BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L).

Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, Geneste O, Kroemer G.

Autophagy. 2007 Jul-Aug;3(4):374-6. Epub 2007 Jul 4.


Anti-cell death engineering of CHO cells: co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction.

Lee JS, Ha TK, Park JH, Lee GM.

Biotechnol Bioeng. 2013 Aug;110(8):2195-207. doi: 10.1002/bit.24879. Epub 2013 Mar 16.


Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1.

Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, Hickman JA, Geneste O, Kroemer G.

EMBO J. 2007 May 16;26(10):2527-39. Epub 2007 Apr 19.


The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells.

Lian J, Karnak D, Xu L.

Autophagy. 2010 Nov;6(8):1201-3. doi: 10.1038/cdd.2010.74. Epub 2010 Nov 16.


The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells.

Gao P, Bauvy C, Souquère S, Tonelli G, Liu L, Zhu Y, Qiao Z, Bakula D, Proikas-Cezanne T, Pierron G, Codogno P, Chen Q, Mehrpour M.

J Biol Chem. 2010 Aug 13;285(33):25570-81. doi: 10.1074/jbc.M110.118125. Epub 2010 Jun 7.


Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).

Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, Bartsch G, Michaelis M, Cinatl J, Haferkamp A, Kögel D.

BMC Cancer. 2015 Apr 7;15:224. doi: 10.1186/s12885-015-1239-4.


BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components.

Andreu-Fernández V, Genovés A, Messeguer A, Orzáez M, Sancho M, Pérez-Payá E.

PLoS One. 2013;8(2):e56881. doi: 10.1371/journal.pone.0056881. Epub 2013 Feb 21.


BH3 mimetics reveal the network properties of autophagy-regulatory signaling cascades.

Malik SA, Shen S, Mariño G, BenYounès A, Maiuri MC, Kroemer G.

Autophagy. 2011 Aug;7(8):914-6. Epub 2011 Aug 1.


DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy.

Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, Sabanay H, Pinkas-Kramarski R, Kimchi A.

EMBO Rep. 2009 Mar;10(3):285-92. doi: 10.1038/embor.2008.246. Epub 2009 Jan 30.


Differential interactions between Beclin 1 and Bcl-2 family members.

Erlich S, Mizrachy L, Segev O, Lindenboim L, Zmira O, Adi-Harel S, Hirsch JA, Stein R, Pinkas-Kramarski R.

Autophagy. 2007 Nov-Dec;3(6):561-8. Epub 2007 Jul 8.


Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.

Oberstein A, Jeffrey PD, Shi Y.

J Biol Chem. 2007 Apr 27;282(17):13123-32. Epub 2007 Mar 2.


The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy.

Nopparat C, Porter JE, Ebadi M, Govitrapong P.

J Pineal Res. 2010 Nov;49(4):382-9. doi: 10.1111/j.1600-079X.2010.00805.x. Epub 2010 Aug 24.


Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL.

Luo S, Rubinsztein DC.

Cell Death Differ. 2010 Feb;17(2):268-77. doi: 10.1038/cdd.2009.121. Epub 2009 Aug 28.


Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.

Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B.

Cell. 2005 Sep 23;122(6):927-39.


The Beclin 1 network regulates autophagy and apoptosis.

Kang R, Zeh HJ, Lotze MT, Tang D.

Cell Death Differ. 2011 Apr;18(4):571-80. doi: 10.1038/cdd.2010.191. Epub 2011 Feb 11. Review.


Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis.

Zhou F, Yang Y, Xing D.

FEBS J. 2011 Feb;278(3):403-13. doi: 10.1111/j.1742-4658.2010.07965.x. Epub 2010 Dec 23. Review.


Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.

Zalckvar E, Berissi H, Eisenstein M, Kimchi A.

Autophagy. 2009 Jul;5(5):720-2. Epub 2009 Jul 2.


[Inhibition of Beclin 1 enhances apoptosis by H2O2 in glioma U251 cells].

Kong XX, Zhang HY, Chen ZQ, Fan XF, Gong YS.

Sheng Li Xue Bao. 2011 Jun 25;63(3):238-44. Chinese.


Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK.

McCoy F, Hurwitz J, McTavish N, Paul I, Barnes C, O'Hagan B, Odrzywol K, Murray J, Longley D, McKerr G, Fennell DA.

Cell Death Dis. 2010 Dec 16;1:e108. doi: 10.1038/cddis.2010.86.

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