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Items: 1 to 20 of 94

1.

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.

Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P.

Nat Med. 2012 May;18(5):791-8. doi: 10.1038/nm.2717.

2.

Protective inflammasome activation in AMD.

Chen J, Smith LE.

Nat Med. 2012 May 4;18(5):658-60. doi: 10.1038/nm.2761.

3.

NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.

Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR.

Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):110-20. doi: 10.1167/iovs.12-10655.

4.

An eye on the future of inflammasomes and drug development in AMD.

Campbell M, Doyle SL.

J Mol Med (Berl). 2013 Sep;91(9):1059-70. doi: 10.1007/s00109-013-1050-0. Epub 2013 May 10. Review.

PMID:
23661041
5.

NLRP3 Inflammasome and Pathobiology in AMD.

Celkova L, Doyle SL, Campbell M.

J Clin Med. 2015 Jan 14;4(1):172-92. doi: 10.3390/jcm4010172. Review.

6.

A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.

Anderson OA, Finkelstein A, Shima DT.

PLoS One. 2013 Jun 28;8(6):e67263. doi: 10.1371/journal.pone.0067263. Print 2013.

7.

Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration.

Ebrahem Q, Renganathan K, Sears J, Vasanji A, Gu X, Lu L, Salomon RG, Crabb JW, Anand-Apte B.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13480-4. Epub 2006 Aug 25. Erratum in: Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15722.

8.

JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration.

Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2377-82. doi: 10.1073/pnas.1221729110. Epub 2013 Jan 22.

9.

An overview of the involvement of interleukin-18 in degenerative retinopathies.

Campbell M, Doyle SL, Ozaki E, Kenna PF, Kiang AS, Humphries MM, Humphries P.

Adv Exp Med Biol. 2014;801:409-15. doi: 10.1007/978-1-4614-3209-8_52. Review.

PMID:
24664725
10.

Drusen complement components C3a and C5a promote choroidal neovascularization.

Nozaki M, Raisler BJ, Sakurai E, Sarma JV, Barnum SR, Lambris JD, Chen Y, Zhang K, Ambati BK, Baffi JZ, Ambati J.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2328-33. Epub 2006 Feb 1.

11.

A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration.

Hollyfield JG, Perez VL, Salomon RG.

Mol Neurobiol. 2010 Jun;41(2-3):290-8. doi: 10.1007/s12035-010-8110-z. Epub 2010 Mar 12.

12.

NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.

Marneros AG.

Cell Rep. 2013 Sep 12;4(5):945-58. doi: 10.1016/j.celrep.2013.08.002. Epub 2013 Sep 5.

13.

T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.

Cruz-Guilloty F, Saeed AM, Duffort S, Cano M, Ebrahimi KB, Ballmick A, Tan Y, Wang H, Laird JM, Salomon RG, Handa JT, Perez VL.

PLoS One. 2014 Feb 19;9(2):e88201. doi: 10.1371/journal.pone.0088201. eCollection 2014.

14.

Inflammation in age-related macular degeneration.

Ozaki E, Campbell M, Kiang AS, Humphries M, Doyle SL, Humphries P.

Adv Exp Med Biol. 2014;801:229-35. doi: 10.1007/978-1-4614-3209-8_30. Review.

PMID:
24664703
15.

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M.

Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616.

16.

VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.

Marneros AG.

Adv Exp Med Biol. 2016;854:79-85. doi: 10.1007/978-3-319-17121-0_12.

PMID:
26427397
17.

The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration.

Ildefonso CJ, Biswal MR, Ahmed CM, Lewin AS.

Adv Exp Med Biol. 2016;854:59-65. doi: 10.1007/978-3-319-17121-0_9. Review.

PMID:
26427394
18.

The purinergic 2X7 receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation.

Solini A, Menini S, Rossi C, Ricci C, Santini E, Blasetti Fantauzzi C, Iacobini C, Pugliese G.

J Pathol. 2013 Nov;231(3):342-53. doi: 10.1002/path.4237. Epub 2013 Sep 3.

PMID:
23843215
19.

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye.

Zheng Q, Ren Y, Reinach PS, She Y, Xiao B, Hua S, Qu J, Chen W.

Exp Eye Res. 2014 Aug;125:1-8. doi: 10.1016/j.exer.2014.05.001. Epub 2014 May 14.

PMID:
24836981
20.

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).

Ramkumar HL, Zhang J, Chan CC.

Prog Retin Eye Res. 2010 May;29(3):169-90. doi: 10.1016/j.preteyeres.2010.02.002. Epub 2010 Mar 3. Review.

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