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Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats.

Fujimoto N, Inoue K, Yoshida M, Nishikawa A, Ozawa S, Gamou T, Nemoto K, Degawa M.

J Toxicol Sci. 2012;37(2):281-6.


Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.

Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, Ozawa S, Inoue K, Yoshida M, Nishikawa A, Degawa M.

J Toxicol Sci. 2011 Oct;36(5):507-14.


Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats.

Phillips JC, Price RJ, Cunninghame ME, Osimitz TG, Cockburn A, Gabriel KL, Preiss FJ, Butler WH, Lake BG.

Fundam Appl Toxicol. 1997 Jul;38(1):64-74.


Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.

Ozawa S, Gamou T, Habano W, Inoue K, Yoshida M, Nishikawa A, Nemoto K, Degawa M.

J Toxicol Sci. 2011 Oct;36(5):613-23.


Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats.

Okamiya H, Mitsumori K, Onodera H, Ito S, Imazawa T, Yasuhara K, Takahashi M.

Arch Toxicol. 1998 Nov;72(11):744-50.


Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.

Morita R, Yafune A, Shiraki A, Itahashi M, Akane H, Nakane F, Suzuki K, Shibutani M, Mitsumori K.

J Toxicol Sci. 2013;38(5):679-88.


Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats.

Muguruma M, Unami A, Kanki M, Kuroiwa Y, Nishimura J, Dewa Y, Umemura T, Oishi Y, Mitsumori K.

Toxicology. 2007 Jul 1;236(1-2):61-75. Epub 2007 Apr 6.


Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency.

Tasaki M, Umemura T, Suzuki Y, Hibi D, Inoue T, Okamura T, Ishii Y, Maruyama S, Nohmi T, Nishikawa A.

Cancer Sci. 2010 Dec;101(12):2525-30. doi: 10.1111/j.1349-7006.2010.01705.x.


Molecular pathological analysis for determining the possible mechanism of piperonyl butoxide-induced hepatocarcinogenesis in mice.

Muguruma M, Nishimura J, Jin M, Kashida Y, Moto M, Takahashi M, Yokouchi Y, Mitsumori K.

Toxicology. 2006 Dec 7;228(2-3):178-87. Epub 2006 Sep 1.


Change in the gene expression of the N-methyl-D-aspartate receptor 2C subunit by dietary β-naphthoflavone, indole-3-carbinol, or acetaminophen in the rat liver.

Nemoto K, Ikeda A, Tanaka T, Inoue K, Yoshida M, Nishikawa A, Gamou T, Habano W, Ozawa S, Degawa M.

J Toxicol Sci. 2013;38(4):611-7.


Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether.

Sakamoto Y, Inoue K, Takahashi M, Taketa Y, Kodama Y, Nemoto K, Degawa M, Gamou T, Ozawa S, Nishikawa A, Yoshida M.

Toxicol Pathol. 2013;41(8):1078-92. doi: 10.1177/0192623313482055. Epub 2013 Mar 26.


Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.

McKim JM Jr, Kolesar GB, Jean PA, Meeker LS, Wilga PC, Schoonhoven R, Swenberg JA, Goodman JI, Gallavan RH, Meeks RG.

Toxicol Appl Pharmacol. 2001 Apr 15;172(2):83-92.


Threshold dose of piperonyl butoxide that induces reactive oxygen species-mediated hepatocarcinogenesis in rats.

Muguruma M, Kawai M, Dewa Y, Nishimura J, Saegusa Y, Yasuno H, Jin M, Matsumoto S, Takabatake M, Arai K, Mitsumori K.

Arch Toxicol. 2009 Feb;83(2):183-93. doi: 10.1007/s00204-008-0340-8. Epub 2008 Jul 22.


Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats from dietary exposure to potassium perfluorooctanesulfonate results from increased expression of xenosensor nuclear receptors PPARα and CAR/PXR.

Elcombe CR, Elcombe BM, Foster JR, Chang SC, Ehresman DJ, Butenhoff JL.

Toxicology. 2012 Mar 11;293(1-3):16-29. doi: 10.1016/j.tox.2011.12.014. Epub 2012 Jan 8.


Effects of pyperonyl butoxide on the female reproductive tract in rats.

Hayashi S, Taketa Y, Inoue K, Takahashi M, Matsuo S, Irie K, Watanabe G, Yoshida M.

J Toxicol Sci. 2013;38(6):891-902.


Neonatal exposure to estrogen differentially alters estrogen receptor alpha and beta mRNA expression in rat testis during postnatal development.

Tena-Sempere M, Navarro J, Pinilla L, González LC, Huhtaniemi I, Aguilar E.

J Endocrinol. 2000 May;165(2):345-57.


Global DNA methylation screening of liver in piperonyl butoxide-treated mice in a two-stage hepatocarcinogenesis model.

Yafune A, Kawai M, Itahashi M, Kimura M, Nakane F, Mitsumori K, Shibutani M.

Toxicol Lett. 2013 Oct 9;222(3):295-302. doi: 10.1016/j.toxlet.2013.08.006. Epub 2013 Aug 19.

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