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Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.

Walker BM, Valdez GR, McLaughlin JP, Bakalkin G.

Alcohol. 2012 Jun;46(4):359-70. doi: 10.1016/j.alcohol.2011.10.006. Epub 2012 Mar 27. Review.


Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process.

Walker BM.

Alcohol. 2012 Jun;46(4):339-48. doi: 10.1016/j.alcohol.2012.01.001. Epub 2012 Mar 28. Review.


The one-two punch of alcoholism: role of central amygdala dynorphins/kappa-opioid receptors.

Kissler JL, Sirohi S, Reis DJ, Jansen HT, Quock RM, Smith DG, Walker BM.

Biol Psychiatry. 2014 May 15;75(10):774-82. doi: 10.1016/j.biopsych.2013.03.014. Epub 2013 Apr 21.


κ opioid regulation of anxiety-like behavior during acute ethanol withdrawal.

Valdez GR, Harshberger E.

Pharmacol Biochem Behav. 2012 Jul;102(1):44-7. doi: 10.1016/j.pbb.2012.03.019. Epub 2012 Apr 2.


Affective cue-induced escalation of alcohol self-administration and increased 22-kHz ultrasonic vocalizations during alcohol withdrawal: role of kappa-opioid receptors.

Berger AL, Williams AM, McGinnis MM, Walker BM.

Neuropsychopharmacology. 2013 Mar;38(4):647-54. doi: 10.1038/npp.2012.229. Epub 2012 Nov 6.


Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.

Gilpin NW, Roberto M, Koob GF, Schweitzer P.

Neuropharmacology. 2014 Feb;77:294-302. doi: 10.1016/j.neuropharm.2013.10.005. Epub 2013 Oct 21.


Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats.

Walker BM, Zorrilla EP, Koob GF.

Addict Biol. 2011 Jan;16(1):116-9. doi: 10.1111/j.1369-1600.2010.00226.x.


The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety.

Schank JR, Goldstein AL, Rowe KE, King CE, Marusich JA, Wiley JL, Carroll FI, Thorsell A, Heilig M.

Addict Biol. 2012 May;17(3):634-47. doi: 10.1111/j.1369-1600.2012.00455.x.


Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions.

Silberman Y, Bajo M, Chappell AM, Christian DT, Cruz M, Diaz MR, Kash T, Lack AK, Messing RO, Siggins GR, Winder D, Roberto M, McCool BA, Weiner JL.

Alcohol. 2009 Nov;43(7):509-19. doi: 10.1016/j.alcohol.2009.01.002. Review.


Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid receptor system.

Gillett K, Harshberger E, Valdez GR.

Alcohol. 2013 Aug;47(5):359-65. doi: 10.1016/j.alcohol.2013.05.001. Epub 2013 May 31.


Dynorphin, stress, and depression.

Knoll AT, Carlezon WA Jr.

Brain Res. 2010 Feb 16;1314:56-73. doi: 10.1016/j.brainres.2009.09.074. Epub 2009 Sep 24. Review.


Treatment of alcohol dependence with drug antagonists of the stress response.

Higley AE, Koob GF, Mason BJ.

Alcohol Res. 2012;34(4):516-21.


Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

Ciccocioppo R, Gehlert DR, Ryabinin A, Kaur S, Cippitelli A, Thorsell A, Lê AD, Hipskind PA, Hamdouchi C, Lu J, Hembre EJ, Cramer J, Song M, McKinzie D, Morin M, Economidou D, Stopponi S, Cannella N, Braconi S, Kallupi M, de Guglielmo G, Massi M, George DT, Gilman J, Hersh J, Tauscher JT, Hunt SP, Hommer D, Heilig M.

Alcohol. 2009 Nov;43(7):491-8. doi: 10.1016/j.alcohol.2009.08.003. Review.


The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse.

Wee S, Koob GF.

Psychopharmacology (Berl). 2010 Jun;210(2):121-35. doi: 10.1007/s00213-010-1825-8. Epub 2010 Mar 30. Review.


The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors.

Bruchas MR, Land BB, Chavkin C.

Brain Res. 2010 Feb 16;1314:44-55. doi: 10.1016/j.brainres.2009.08.062. Epub 2009 Aug 28. Review.


[Place of the opioid system in biology and treatment of Alcohol Use Disorder].

Nubukpo P.

Encephale. 2014 Dec;40(6):457-67. doi: 10.1016/j.encep.2014.10.010. Epub 2014 Nov 22. Review. French.


Alcohol withdrawal and conditioning.

Little HJ, Stephens DN, Ripley TL, Borlikova G, Duka T, Schubert M, Albrecht D, Becker HC, Lopez MF, Weiss F, Drummond C, Peoples M, Cunningham C.

Alcohol Clin Exp Res. 2005 Mar;29(3):453-64. Review.


Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system.

Sirohi S, Bakalkin G, Walker BM.

Front Mol Neurosci. 2012 Sep 27;5:95. doi: 10.3389/fnmol.2012.00095. eCollection 2012.


Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system.

Donahue RJ, Landino SM, Golden SA, Carroll FI, Russo SJ, Carlezon WA Jr.

Behav Pharmacol. 2015 Oct;26(7 Spec No):654-63. doi: 10.1097/FBP.0000000000000155.


Alcoholism: allostasis and beyond.

Koob GF.

Alcohol Clin Exp Res. 2003 Feb;27(2):232-43. Review.

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