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Results: 1 to 20 of 107

1.

Experiences in fragment-based drug discovery.

Murray CW, Verdonk ML, Rees DC.

Trends Pharmacol Sci. 2012 May;33(5):224-32. doi: 10.1016/j.tips.2012.02.006. Epub 2012 Mar 27.

PMID:
22459076
[PubMed - indexed for MEDLINE]
2.

The multiple roles of computational chemistry in fragment-based drug design.

Law R, Barker O, Barker JJ, Hesterkamp T, Godemann R, Andersen O, Fryatt T, Courtney S, Hallett D, Whittaker M.

J Comput Aided Mol Des. 2009 Aug;23(8):459-73. doi: 10.1007/s10822-009-9284-1. Epub 2009 Jun 17.

PMID:
19533374
[PubMed - indexed for MEDLINE]
3.

Effective progression of nuclear magnetic resonance-detected fragment hits.

Eaton HL, Wyss DF.

Methods Enzymol. 2011;493:447-68. doi: 10.1016/B978-0-12-381274-2.00017-0.

PMID:
21371601
[PubMed - indexed for MEDLINE]
4.

[Fragment-based drug discovery: concept and aim].

Tanaka D.

Yakugaku Zasshi. 2010 Mar;130(3):315-23. Review. Japanese.

PMID:
20190516
[PubMed - indexed for MEDLINE]
Free Article
5.

Rationalizing fragment based drug discovery for BACE1: insights from FB-QSAR, FB-QSSR, multi objective (MO-QSPR) and MIF studies.

Manoharan P, Vijayan RS, Ghoshal N.

J Comput Aided Mol Des. 2010 Oct;24(10):843-64. doi: 10.1007/s10822-010-9378-9. Epub 2010 Aug 26.

PMID:
20740315
[PubMed - indexed for MEDLINE]
6.

Introduction to fragment-based drug discovery.

Erlanson DA.

Top Curr Chem. 2012;317:1-32. doi: 10.1007/128_2011_180. Review.

PMID:
21695633
[PubMed - indexed for MEDLINE]
7.

In silico fragment-based drug design.

Konteatis ZD.

Expert Opin Drug Discov. 2010 Nov;5(11):1047-65. doi: 10.1517/17460441.2010.523697. Epub 2010 Oct 8. Review.

PMID:
22827744
[PubMed - indexed for MEDLINE]
8.

Fragment informatics and computational fragment-based drug design: an overview and update.

Sheng C, Zhang W.

Med Res Rev. 2013 May;33(3):554-98. doi: 10.1002/med.21255. Epub 2012 Mar 19. Review.

PMID:
22430881
[PubMed - indexed for MEDLINE]
9.

Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.

Wyss DF, Wang YS, Eaton HL, Strickland C, Voigt JH, Zhu Z, Stamford AW.

Top Curr Chem. 2012;317:83-114. doi: 10.1007/128_2011_183. Review.

PMID:
21647837
[PubMed - indexed for MEDLINE]
10.

Fragment-based approaches in drug discovery and chemical biology.

Scott DE, Coyne AG, Hudson SA, Abell C.

Biochemistry. 2012 Jun 26;51(25):4990-5003. doi: 10.1021/bi3005126. Epub 2012 Jun 14. Review.

PMID:
22697260
[PubMed - indexed for MEDLINE]
11.

Fragment based drug design: from experimental to computational approaches.

Kumar A, Voet A, Zhang KY.

Curr Med Chem. 2012;19(30):5128-47. Review.

PMID:
22934764
[PubMed - indexed for MEDLINE]
12.

Transforming fragments into candidates: small becomes big in medicinal chemistry.

de Kloe GE, Bailey D, Leurs R, de Esch IJ.

Drug Discov Today. 2009 Jul;14(13-14):630-46. doi: 10.1016/j.drudis.2009.03.009. Epub 2009 Mar 31. Review.

PMID:
19443265
[PubMed - indexed for MEDLINE]
13.

The rise of fragment-based drug discovery.

Murray CW, Rees DC.

Nat Chem. 2009 Jun;1(3):187-92. doi: 10.1038/nchem.217. Review.

PMID:
21378847
[PubMed - indexed for MEDLINE]
14.

Combining biophysical screening and X-ray crystallography for fragment-based drug discovery.

Hennig M, Ruf A, Huber W.

Top Curr Chem. 2012;317:115-43. doi: 10.1007/128_2011_225. Review.

PMID:
21837555
[PubMed - indexed for MEDLINE]
15.

Fragment approaches in structure-based drug discovery.

Hubbard RE.

J Synchrotron Radiat. 2008 May;15(Pt 3):227-30. doi: 10.1107/S090904950705666X. Epub 2008 Apr 18.

PMID:
18421145
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Advances in fragment-based drug discovery platforms.

Orita M, Warizaya M, Amano Y, Ohno K, Niimi T.

Expert Opin Drug Discov. 2009 Nov;4(11):1125-44. doi: 10.1517/17460440903317580.

PMID:
23480433
[PubMed]
17.

Contributions of computational chemistry and biophysical techniques to fragment-based drug discovery.

Gozalbes R, Carbajo RJ, Pineda-Lucena A.

Curr Med Chem. 2010;17(17):1769-94. Review.

PMID:
20345344
[PubMed - indexed for MEDLINE]
18.

Informatics and modeling challenges in fragment-based drug discovery.

Hubbard RE, Chen I, Davis B.

Curr Opin Drug Discov Devel. 2007 May;10(3):289-97. Review.

PMID:
17554855
[PubMed - indexed for MEDLINE]
19.

Integration of fragment screening and library design.

Siegal G, Ab E, Schultz J.

Drug Discov Today. 2007 Dec;12(23-24):1032-9. Epub 2007 Oct 2. Review.

PMID:
18061882
[PubMed - indexed for MEDLINE]
20.

Design of a multi-purpose fragment screening library using molecular complexity and orthogonal diversity metrics.

Lau WF, Withka JM, Hepworth D, Magee TV, Du YJ, Bakken GA, Miller MD, Hendsch ZS, Thanabal V, Kolodziej SA, Xing L, Hu Q, Narasimhan LS, Love R, Charlton ME, Hughes S, van Hoorn WP, Mills JE.

J Comput Aided Mol Des. 2011 Jul;25(7):621-36. doi: 10.1007/s10822-011-9434-0. Epub 2011 May 21.

PMID:
21604056
[PubMed - indexed for MEDLINE]

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