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Results: 1 to 20 of 113

1.

Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma.

Hu YL, DeLay M, Jahangiri A, Molinaro AM, Rose SD, Carbonell WS, Aghi MK.

Cancer Res. 2012 Apr 1;72(7):1773-83. doi: 10.1158/0008-5472.CAN-11-3831. Epub 2012 Mar 23.

PMID:
22447568
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance.

Jahangiri A, De Lay M, Miller LM, Carbonell WS, Hu YL, Lu K, Tom MW, Paquette J, Tokuyasu TA, Tsao S, Marshall R, Perry A, Bjorgan KM, Chaumeil MM, Ronen SM, Bergers G, Aghi MK.

Clin Cancer Res. 2013 Apr 1;19(7):1773-83. doi: 10.1158/1078-0432.CCR-12-1281. Epub 2013 Jan 10.

PMID:
23307858
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.

Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F.

Cell Cycle. 2010 Sep 1;9(17):3515-33. Epub 2010 Sep 9.

PMID:
20855962
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma.

Carbonell WS, DeLay M, Jahangiri A, Park CC, Aghi MK.

Cancer Res. 2013 May 15;73(10):3145-54. doi: 10.1158/0008-5472.CAN-13-0011. Epub 2013 May 3.

PMID:
23644530
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapy.

Selvakumaran M, Amaravadi RK, Vasilevskaya IA, O'Dwyer PJ.

Clin Cancer Res. 2013 Jun 1;19(11):2995-3007. doi: 10.1158/1078-0432.CCR-12-1542. Epub 2013 Mar 5.

PMID:
23461901
[PubMed - indexed for MEDLINE]
Free Article
6.

Microarray analysis verifies two distinct phenotypes of glioblastomas resistant to antiangiogenic therapy.

DeLay M, Jahangiri A, Carbonell WS, Hu YL, Tsao S, Tom MW, Paquette J, Tokuyasu TA, Aghi MK.

Clin Cancer Res. 2012 May 15;18(10):2930-42. doi: 10.1158/1078-0432.CCR-11-2390. Epub 2012 Apr 3.

PMID:
22472177
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo.

Yuan G, Yan SF, Xue H, Zhang P, Sun JT, Li G.

J Biol Chem. 2014 Apr 11;289(15):10607-19. doi: 10.1074/jbc.M113.528760. Epub 2014 Mar 5.

PMID:
24599950
[PubMed - indexed for MEDLINE]
8.

Autophagy inhibition induces enhanced proapoptotic effects of ZD6474 in glioblastoma.

Shen J, Zheng H, Ruan J, Fang W, Li A, Tian G, Niu X, Luo S, Zhao P.

Br J Cancer. 2013 Jul 9;109(1):164-71. doi: 10.1038/bjc.2013.306. Epub 2013 Jun 25.

PMID:
23799852
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.

Bota DA, Alexandru D, Keir ST, Bigner D, Vredenburgh J, Friedman HS.

J Neurosurg. 2013 Dec;119(6):1415-23. doi: 10.3171/2013.7.JNS1323. Epub 2013 Oct 4.

PMID:
24093630
[PubMed - indexed for MEDLINE]
10.

Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.

Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Gehrs B, Raffeld M, Kinders RJ, Parchment R, Anver MR, Shoemaker RH, Melillo G.

Mol Cancer Ther. 2009 Jul;8(7):1867-77. doi: 10.1158/1535-7163.MCT-09-0274. Epub 2009 Jul 7.

PMID:
19584228
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1.

Chou CW, Wang CC, Wu CP, Lin YJ, Lee YC, Cheng YW, Hsieh CH.

Neuro Oncol. 2012 Oct;14(10):1227-38. Epub 2012 Sep 3.

PMID:
22946104
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.

Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM.

Mol Cell Biol. 2009 May;29(10):2570-81. doi: 10.1128/MCB.00166-09. Epub 2009 Mar 9.

PMID:
19273585
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

Papandreou I, Lim AL, Laderoute K, Denko NC.

Cell Death Differ. 2008 Oct;15(10):1572-81. doi: 10.1038/cdd.2008.84. Epub 2008 Jun 13.

PMID:
18551130
[PubMed - indexed for MEDLINE]
Free Article
14.

Modulating antiangiogenic resistance by inhibiting the signal transducer and activator of transcription 3 pathway in glioblastoma.

de Groot J, Liang J, Kong LY, Wei J, Piao Y, Fuller G, Qiao W, Heimberger AB.

Oncotarget. 2012 Sep;3(9):1036-48.

PMID:
23013619
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-dependent autophagy protects human dental pulp cells against hypoxia.

Zhou Q, Liu H, Sun Q, Zhang L, Lin H, Yuan G, Zhang L, Chen Z.

J Endod. 2013 Jun;39(6):768-73. doi: 10.1016/j.joen.2013.02.001. Epub 2013 Mar 16.

PMID:
23683277
[PubMed - indexed for MEDLINE]
16.

DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, Harris AL.

Cancer Res. 2011 Sep 15;71(18):6073-83. doi: 10.1158/0008-5472.CAN-11-1704. Epub 2011 Jul 29.

PMID:
21803743
[PubMed - indexed for MEDLINE]
Free Article
17.

The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia.

Burton TR, Henson ES, Baijal P, Eisenstat DD, Gibson SB.

Int J Cancer. 2006 Apr 1;118(7):1660-9.

PMID:
16217754
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma.

Guo XL, Li D, Sun K, Wang J, Liu Y, Song JR, Zhao QD, Zhang SS, Deng WJ, Zhao X, Wu MC, Wei LX.

J Mol Med (Berl). 2013 Apr;91(4):473-83. doi: 10.1007/s00109-012-0966-0. Epub 2012 Oct 10.

PMID:
23052483
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype.

Piao Y, Liang J, Holmes L, Zurita AJ, Henry V, Heymach JV, de Groot JF.

Neuro Oncol. 2012 Nov;14(11):1379-92. doi: 10.1093/neuonc/nos158. Epub 2012 Sep 10.

PMID:
22965162
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme.

Hsieh CH, Wu CP, Lee HT, Liang JA, Yu CY, Lin YJ.

Free Radic Biol Med. 2012 Aug 15;53(4):649-58. doi: 10.1016/j.freeradbiomed.2012.06.009. Epub 2012 Jun 16.

PMID:
22713363
[PubMed - indexed for MEDLINE]

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