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Results: 1 to 20 of 109

Similar articles for PubMed (Select 22446838)

1.

Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands.

Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M.

Nat Chem Biol. 2012 Mar 25;8(5):455-64. doi: 10.1038/nchembio.917.

2.

Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.

Tan KR, Baur R, Charon S, Goeldner M, Sigel E.

J Neurochem. 2009 Dec;111(5):1264-73. doi: 10.1111/j.1471-4159.2009.06419.x. Epub 2009 Oct 5.

PMID:
19804380
3.

Medicinal chemistry of indolylglyoxylamide GABAA/BzR high affinity ligands: identification of novel anxiolytic/non sedative agents.

Salerno S, Da Settimo F, Taliani S, Simorini F, La Motta C, Fornaciari G, Marini AM.

Curr Top Med Chem. 2012;12(4):286-311. Review.

PMID:
22204484
4.

Ligands for the benzodiazepine binding site--a survey.

Teuber L, Wätjens F, Jensen LH.

Curr Pharm Des. 1999 May;5(5):317-43. Review.

PMID:
10213798
5.

Discovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABAA receptor interaction via the benzodiazepine-binding site.

Pejović A, Denić MS, Stevanović D, Damljanović I, Vukićević M, Kostova K, Tavlinova-Kirilova M, Randjelović P, Stojanović NM, Bogdanović GA, Blagojević P, D'hooghe M, Radulović NS, Vukićević RD.

Eur J Med Chem. 2014 Aug 18;83:57-73. doi: 10.1016/j.ejmech.2014.05.062. Epub 2014 May 28.

PMID:
24950490
6.

On the benzodiazepine binding pocket in GABAA receptors.

Berezhnoy D, Nyfeler Y, Gonthier A, Schwob H, Goeldner M, Sigel E.

J Biol Chem. 2004 Jan 30;279(5):3160-8. Epub 2003 Nov 11.

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The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes.

Ramerstorfer J, Furtmüller R, Vogel E, Huck S, Sieghart W.

Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. doi: 10.1016/j.ejphar.2010.03.015. Epub 2010 Mar 19.

PMID:
20303942
12.

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.

Nat Neurosci. 2000 Jun;3(6):587-92.

PMID:
10816315
13.

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.

Hintermann S, Hurth K, Nozulak J, Tintelnot-Blomley M, Aichholz R, Blanz J, Kaupmann K, Mosbacher J.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1523-6. doi: 10.1016/j.bmcl.2010.12.107. Epub 2010 Dec 28.

PMID:
21277199
14.

Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation.

Leppä E, Linden AM, Rabe H, Vekovischeva OY, Wulff P, Lüddens H, Wisden W, Korpi ER.

Eur J Pharmacol. 2011 Sep;666(1-3):111-21. doi: 10.1016/j.ejphar.2011.05.011. Epub 2011 May 19.

PMID:
21616065
15.

Geometrically constrained derivatives of indolylglyoxylamides as ligands binding the GABAA/BzR complex.

Sartini S, Morelli M, Simorini F, Taliani S, Salerno S, Marini AM, Da Settimo F, La Motta C.

Curr Top Med Chem. 2012;12(4):312-20. Review.

PMID:
22204489
16.

Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.

Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM.

Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25.

17.

Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.

Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.

J Neurochem. 2008 Sep;106(6):2353-63. doi: 10.1111/j.1471-4159.2008.05574.x. Epub 2008 Jul 15.

PMID:
18643789
18.

Recent developments in potential anxiolytic agents targeting GABAA/BzR complex or the translocator protein (18kDa) (TSPO).

Nothdurfter C, Rupprecht R, Rammes G.

Curr Top Med Chem. 2012;12(4):360-70. Review.

PMID:
22204486
19.

New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (omega) receptor subtypes.

Griebel G, Perrault G, Letang V, Granger P, Avenet P, Schoemaker H, Sanger DJ.

Psychopharmacology (Berl). 1999 Sep;146(2):205-13.

PMID:
10525757
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