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Items: 1 to 20 of 228

1.

Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y.

PLoS One. 2012;7(3):e33870. doi: 10.1371/journal.pone.0033870. Epub 2012 Mar 19.

2.

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice.

Wu X, Ge H, Lemon B, Weiszmann J, Gupte J, Hawkins N, Li X, Tang J, Lindberg R, Li Y.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14379-84. doi: 10.1073/pnas.0907812106. Epub 2009 Aug 12.

3.

Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation.

Luo Y, Yang C, Lu W, Xie R, Jin C, Huang P, Wang F, McKeehan WL.

J Biol Chem. 2010 Sep 24;285(39):30069-78. doi: 10.1074/jbc.M110.148288. Epub 2010 Jul 23.

4.

Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress.

Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y.

Nutr Metab (Lond). 2012 Oct 30;9(1):94. doi: 10.1186/1743-7075-9-94.

5.

Dynamics and Distribution of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex.

Ming AY, Yoo E, Vorontsov EN, Altamentova SM, Kilkenny DM, Rocheleau JV.

J Biol Chem. 2012 Jun 8;287(24):19997-20006. doi: 10.1074/jbc.M111.325670. Epub 2012 Apr 20.

6.

Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies.

Antonellis PJ, Kharitonenkov A, Adams AC.

J Anim Sci. 2014 Feb;92(2):407-13. doi: 10.2527/jas.2013-7076. Epub 2014 Jan 7.

7.

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M.

J Biol Chem. 2007 Sep 14;282(37):26687-95. Epub 2007 Jul 10.

8.

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue.

Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, Luo Y, Kharitonenkov A.

Mol Metab. 2012 Aug 28;2(1):31-7. doi: 10.1016/j.molmet.2012.08.007. eCollection 2012.

9.

Fundamentals of FGF19 & FGF21 action in vitro and in vivo.

Adams AC, Coskun T, Rovira AR, Schneider MA, Raches DW, Micanovic R, Bina HA, Dunbar JD, Kharitonenkov A.

PLoS One. 2012;7(5):e38438. doi: 10.1371/journal.pone.0038438. Epub 2012 May 31.

10.

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, Hecht R, Gupte J, Hager T, Wang Z, Lindberg R, Li Y.

J Biol Chem. 2010 Feb 19;285(8):5165-70. doi: 10.1074/jbc.M109.068783. Epub 2009 Dec 15.

11.

The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21.

Gupte J, Yang L, Wu X, Weiszmann J, Hecht R, Lemon B, Lindberg R, Wang Z, Li Y.

J Mol Biol. 2011 May 6;408(3):491-502. doi: 10.1016/j.jmb.2011.03.003. Epub 2011 Mar 23.

PMID:
21392510
12.

Liver-specific activities of FGF19 require Klotho beta.

Lin BC, Wang M, Blackmore C, Desnoyers LR.

J Biol Chem. 2007 Sep 14;282(37):27277-84. Epub 2007 Jul 11.

13.

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

Yang C, Lu W, Lin T, You P, Ye M, Huang Y, Jiang X, Wang C, Wang F, Lee MH, Yeung SC, Johnson RL, Wei C, Tsai RY, Frazier ML, McKeehan WL, Luo Y.

BMC Gastroenterol. 2013 Apr 17;13:67. doi: 10.1186/1471-230X-13-67.

14.

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients.

Gallego-Escuredo JM, Gómez-Ambrosi J, Catalan V, Domingo P, Giralt M, Frühbeck G, Villarroya F.

Int J Obes (Lond). 2015 Jan;39(1):121-9. doi: 10.1038/ijo.2014.76. Epub 2014 May 12.

PMID:
24813368
15.

Reduced levels of serum FGF19 and impaired expression of receptors for endocrine FGFs in adipose tissue from HIV-infected patients.

Gallego-Escuredo JM, Domingo P, Gutiérrez Mdel M, Mateo MG, Cabeza MC, Fontanet A, Vidal F, Domingo JC, Giralt M, Villarroya F.

J Acquir Immune Defic Syndr. 2012 Dec 15;61(5):527-34. doi: 10.1097/QAI.0b013e318271c2c7.

PMID:
23187887
16.

FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways.

Wu AL, Coulter S, Liddle C, Wong A, Eastham-Anderson J, French DM, Peterson AS, Sonoda J.

PLoS One. 2011 Mar 18;6(3):e17868. doi: 10.1371/journal.pone.0017868.

17.

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice.

Véniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, Vonderfecht S, Xu J, Lloyd DJ.

PLoS One. 2012;7(7):e40164. doi: 10.1371/journal.pone.0040164. Epub 2012 Jul 6.

18.

FGF21 requires βklotho to act in vivo.

Adams AC, Cheng CC, Coskun T, Kharitonenkov A.

PLoS One. 2012;7(11):e49977. doi: 10.1371/journal.pone.0049977. Epub 2012 Nov 27.

19.

Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism.

Ge H, Baribault H, Vonderfecht S, Lemon B, Weiszmann J, Gardner J, Lee KJ, Gupte J, Mookherjee P, Wang M, Sheng J, Wu X, Li Y.

PLoS One. 2012;7(3):e33603. doi: 10.1371/journal.pone.0033603. Epub 2012 Mar 23.

20.

A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho.

Wu X, Weiszmann J, Ge H, Baribault H, Stevens J, Hawkins N, Vonderfecht S, Gardner J, Gupte J, Sheng J, Wang M, Li Y.

J Mol Biol. 2012 Apr 20;418(1-2):82-9. doi: 10.1016/j.jmb.2012.02.027. Epub 2012 Feb 24.

PMID:
22370560
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